Tryptophan Metabolism and Gut Microbiota  

作　　者：Akikazu Takada Akikazu Takada(Hamamatsu University School of Medicine, NPO “International Projects on Food and Health”, Hamamatsu, Japan)

机构地区：[1]Hamamatsu University School of Medicine, NPO “International Projects on Food and Health”, Hamamatsu, Japan

出　　处：《Food and Nutrition Sciences》2023年第8期777-790,共14页食品与营养科学（英文）

摘　　要：Background: Tryptophan metabolites such as serotonin, kynurenine, or kynurenic acids are considered to be the most important metabolites of gut microbiota. We wanted to know about changes in tryptophan metabolites in various diseases in which the etiology gut microbiota are considered to participate. Methods: Ultra-high speed liquid chromatography/mass spectroscopy (LC/MS) has been used to analyze simultaneously all the tryptophan metabolites, which we have explored for the first time in the world. Results: We analyzed plasma levels of tryptophan metabolites in patients with depression, autism, diabetes mellitus ‘DM’), and acute coronary syndrome (ACS). Of all the metabolites serotonin and kynurenine levels of these patients were higher than those of controls. Conclusion: Measurements of tryptophan metabolites in plasma of various diseases are important to know roles of gut microbiota in etiology, further therapeutic measures.Background: Tryptophan metabolites such as serotonin, kynurenine, or kynurenic acids are considered to be the most important metabolites of gut microbiota. We wanted to know about changes in tryptophan metabolites in various diseases in which the etiology gut microbiota are considered to participate. Methods: Ultra-high speed liquid chromatography/mass spectroscopy (LC/MS) has been used to analyze simultaneously all the tryptophan metabolites, which we have explored for the first time in the world. Results: We analyzed plasma levels of tryptophan metabolites in patients with depression, autism, diabetes mellitus ‘DM’), and acute coronary syndrome (ACS). Of all the metabolites serotonin and kynurenine levels of these patients were higher than those of controls. Conclusion: Measurements of tryptophan metabolites in plasma of various diseases are important to know roles of gut microbiota in etiology, further therapeutic measures.

关 键 词：TRYPTOPHAN SEROTONIN MICROBIOTA DEPRESSION Obesity KYNURENINE Blood Brain Barrier KYNURENINE Permeability AUTISM DEPRESSION Diabetes 

分 类 号：R57[医药卫生—消化系统]