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作品数：599被引量：2359H指数：22
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相关机构：南方医科大学复旦大学福建省肿瘤医院中国人民解放军总医院更多>>
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Plasma circulating cell–free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson's disease and multiple system atrophy:a cross-sectional study
《Neural Regeneration Research》2025年第12期3553-3563,共11页Chao Ying Chao Han Yuan Li Mingkai Zhang Shuying Xiao Lifang Zhao Hui Zhang Qian Yu Jing An Wei Mao Yanning Cai 
supported by the National Key Research and Development Program of China,No.2021YFC2501205(to YC);the Science and Technology Innovation 2030 project,No.2021ZD0201101(to YC);the National Natural Science Foundation of China,Nos.82201409(to YL),82201401(to CH);the Xuanwu Youth Development Project,No.QNPY2021011(to CH)。
In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy are ...
关键词：biomarkers cell-free DNA diagnosis multiple system atrophy neurodegenerative diseases Parkinson’s disease risk factors 
Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin
《Neural Regeneration Research》2025年第5期1445-1454,共10页Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou 
supported by STI2030-Major Projects,No.2022ZD0207600(to LZ);the National Natural Science Foundation of China,Nos.32070955(to LZ),U22A20301(to KFS);the Natural Science Foundation of Guangdong Province,No.2021A1515012197(to HO);Guangzhou Core Medical Disciplines Project,No.2021-2023(to HO);Key Research and Development Plan of Ningxia Hui Automomous Region,No.2022BEG01004(to KFS);Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and LZ)。
Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitatio...
关键词：ADIPONECTIN cerebral ischemia exercise pre-conditioning HIPPOCAMPUS memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise 
Circulating circular RNAs act as potential novel biomarkers for sepsis secondary to pneumonia:a prospective cohort study
《World Journal of Emergency Medicine》2025年第2期144-152,共9页Chunxue Wang Dianyin Yang Yuxin Zhu Qian Yang Tong Liu Xiandong Liu Dongyang Zhao Xiaowei Bao Tiancao Dong Li Shao Lunxian Tang 
supported by grants from the municipal Natural Science Foundation of Shanghai Scientific Committee of China(22ZR1451000 to TL);the peak supporting clinical discipline of Shanghai Health Bureau(2023ZDFC0104 to TL);the key clinical discipline of Shanghai Pudong Health Bureau(PWZxk2022-17 to TL);the clinical peak discipline of Shanghai Pudong Heath Bureau(PWYgf2021-03);the top-notch innovative medical talents of Shanghai Pudong Health Bureau(2025PDWSYCBJ-03 to TL);the leading medical talent project of Shanghai Pudong Heath Bureau(PWR12020-07 to LS)。
BACKGROUND:Circulating biomarkers for sepsis are lacking,and research on circular RNAs(circR NAs)as potential biomarkers of pneumonia-induced sepsis is limited.This study aims to investigate the diagnostic and prognos...
关键词：Circular RNAs BIOMARKER Pneumonia-induced sepsis Diagnosis Prognosis 
Epidemiology and Genetic Evolution of Influenza B Viruses Circulating in the Democratic Republic of Congo from 2015 to 2022: Implication of Vaccination
《Open Journal of Respiratory Diseases》2025年第1期1-18,共18页Edith Nkwembe Ngabana Youdhie Ituneme N’ka Flabo Grace Mufwaya Makayi Leonie Manya Kitoto Saleh Muhemedi Kayumba Pélagie Babakazo Hugo Kavunga Membo Steve Ahuka Mundeke 
Introduction: Influenza A (Flu A) and B (Flu B) viruses are responsible for severe acute respiratory infections (SARI) worldwide, with a morbidity of 5 million and mortality of 29,000 - 650,000 deaths per year. Influe...
关键词：EPIDEMIOLOGY Genetic Evolution Influenza B Viruses DRC 
Cholangiocarcinoma:The era of liquid biopsy
《World Journal of Gastroenterology》2025年第11期14-32,共19页Evgenia Kotsifa Francesca Saffioti Vasileios K Mavroeidis 
Cholangiocarcinoma(CCA)is a highly aggressive and heterogeneous malignancy arising from the epithelial cells of the biliary tract.The limitations of the current methods in the diagnosis of CCA highlight the urgent nee...
关键词：Biliary tract cancer CHOLANGIOCARCINOMA Circulating tumour cells Cell free DNA Circulating tumour DNA Circulating RNA Biomarkers Extracellular vesicles Precision medicine 
Catching cancer signals in the blood:Innovative pathways for early esophageal cancer diagnosis
《World Journal of Gastroenterology》2025年第10期1-6,共6页Yue Zhao Zhan Zhang Jian-Hao Qiu Rong-Yang Li Zhen-Guo Sun 
Supported by The National Key R and D Program of China,No.2021YFC2500904,No.2021YFC2500905 and No.2021YFC2500900;Shandong Provincial Natural Science Foundation,No.ZR2023MH130 and No.ZR2017BH035;China Postdoctoral Science Foundation,No.2020M672073;National Natural Science Foundation of China,No.81802397.
In recent years,significant progress has been made in the application of DNA methylation for the early detection of esophageal cancer(EC).As an epigenetic modification,DNA methylation allows for noninvasive screening ...
关键词：Esophageal cancer DNA methylation Circulating tumor DNA Early detection Liquid biopsy Treatment monitoring 
Numerical simulations of gas-liquid-solid circulating flows coupled to mesoscale parameters and measurements
《Particuology》2025年第2期236-256,共21页Lubin Zhang Yongli Ma Mingyan Liu 
This work was supported by the National Natural Science Foundation of China(grant No.22008169);the Open Research Fund of State Key Laboratory of Multiphase Complex Systems(grant No.MPCS-2021-D-06).
Gas-liquid-solid circulating fluidized bed(GLSCFB)is an important type of chemical reactor.The complex mesoscale flow structure of GLSCFB was described through the mesoscale flow structure parameters based on the ener...
关键词：Gas-liquid-solid circulating fluidized bed Energy-minimization multi-scale model Unified wake model Computational fluid dynamics Particle cluster 
Inter-basin groundwater flow in the Ordos Basin:Evidence of environmental isotope and hydrological investigations
《Geoscience Frontiers》2025年第1期249-260,共12页Yitong Zhang Jiaqi Chen Jiansheng Chen Wang Wang 
supported by the National Natural Science Foundation of China(Grant No.61771183).
The Ordos Basin,located in arid and semi-arid region of China,is famous for its abundant groundwater resources and artesian features.The source of groundwater recharge,whether from local precipitation or external sour...
关键词：Groundwater circulation Ordos Basin Artesian basins Deep-circulating groundwater 
Ex vivo STAT3 phosphorylation in circulating immune cells:a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy
《Cancer Communications》2025年第1期58-62,共5页Sung-Woo Lee Young Ju Kim Saei Jeong Kyung Na Rho Jeong Eun Noh Hee-Ok Kim Hyun-Ju Cho Yoo Duk Choi Deok Hwan Yang Eu Chang Hwang Woo Kyun Bae Sook Jung Yun Ju Sik Yun Cheol-Kyu Park In-Jae Oh Jae-Ho Cho 
funded by National Research Foundation of Korea(2020R1A5A2031185,2020M3A9G3080281,2022R1A2C2009385,2020M3A9G3080330,and 2022R1A6A3A01086438).
Basal signal transducer and activator of transcription 3(STAT3)activation is well-documented in the tumor microenvironment(TME)due to its association with cancer prognosis[1].However,its presence and clinical relevanc...
关键词：STAT3 VIVO DIAGNOSIS 
Genomic landscape of circulating tumor DNA in HER2-low metastatic breast cancer
《Signal Transduction and Targeted Therapy》2025年第1期293-302,共10页Zongbi Yi Kaixiang Feng Dan Lv Yanfang Guan Youcheng Shao Fei Ma Binghe Xu 
supported by the National Science Fund of China(Grant No.82303823);the CAMS Innovation Fund for Medical Sciences(Grant Nos.2021-I2M-1-014,2023-12M-2-004);the Wuhan Municipal Science and Technology Bureau Knowledge Innovation Special Project“Dawn Plan”Project(Grant No.KYXM2022011);the Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNQNJC2022006).
The large population of HER2-low breast cancer patients necessitates further research to provide enhanced clinical guidance.In this study,we retrospectively analyzed 1071 metastatic breast cancer(MBC)patients and the ...
关键词：alterations HER2 TREATMENT 
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