supported by STI2030-Major Projects,No.2022ZD0207600(to LZ);the National Natural Science Foundation of China,Nos.32070955(to LZ),U22A20301(to KFS);the Natural Science Foundation of Guangdong Province,No.2021A1515012197(to HO);Guangzhou Core Medical Disciplines Project,No.2021-2023(to HO);Key Research and Development Plan of Ningxia Hui Automomous Region,No.2022BEG01004(to KFS);Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and LZ)。
Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitatio...
BACKGROUND Adult-onset diabetes is most often considered to be type 2 diabetes.However,other types of diabetes can develop in adults,including exocrine pancreas diseaseassociated diabetes,also called type 3c diabetes....
Supported by National Natural Science Foundation of China(General Program),No.82070852 and No.82270901.
BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not clear.AIM To study the morphological and functional changes in adipose tissue after DJB and explore the poten...
supported by the grants from the CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.:2021-I2M-1-026);the Beijing Natural Science Foundation of China(Grant Nos.:7212155 and 7162135).
Obesity and related metabolic syndromes have been recognized as important disease risks,in which the role of adipokines cannot be ignored.Adiponectin(ADP)is one of the key adipokines with various beneficial effects,in...
Objectives: To explore the relationship between adiponectin (APN) and bone mineral density in this Zhuang ethnic group, thus providing a basis underpinning the prevention and treatment of osteoporosis (OP). Methods: Z...
This current review highlights adiponectin engagement with AdipoR1 and AdipoR2 which subsequently triggers pathways such as AMPK,PPARα,and MAPK,thereby modulating testicular steroidogenesis.Adiponectin's actions on L...
Nutrient metabolism is regulated by several factors.Social determinants of health with or without genetics are the primary regulator of metabolism,and an unhealthy lifestyle affects all modulators and mediators,leadin...
supported by the Project of the Jilin Science and Technology Development Program[20220401085YY].
Hepatic fibrosis,a degenerative liver lesion,significantly contributes to the deterioration and mortality among patients with chronic liver diseases.The condition arises from various factors including toxins,such as a...
This work was supported by the Basic Science Research Program of the National Research Foundation of Korea(NRF)(NRF-2021R1A2C1013132);Basic Science Research Program through the National Research Foundation of Korea(NRF)(2020R1A6A1A03044512).The authors thank the Core Research Support Center for Natural Products and Medical Materials(CRCNM)for the technical support regarding the confocal microscopic analysis.
Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese MSC.In this study,w...
Boiogito (BOT) ameliorates insulin resistance and diabetes in several animal models;however, the underlying mechanisms for these in vivo effects remain unclear. Thiazolidine derivatives, which are peroxisome prolifera...