Adiponectin orchestrates testosterone suppression in biological pathways  

作　　者：Ekhoye Ehitare Ikekhuamen Imonna Kingsley 

机构地区：[1]Human Physiology,Edo State University Uzairue,Nigeria [2]Public Health,Edo State University Uzairue,Nigeria

出　　处：《Asian pacific Journal of Reproduction》2024年第2期52-59,共8页亚太生殖杂志（英文版）

摘　　要：This current review highlights adiponectin engagement with AdipoR1 and AdipoR2 which subsequently triggers pathways such as AMPK,PPARα,and MAPK,thereby modulating testicular steroidogenesis.Adiponectin's actions on Leydig and adrenal cells inhibit androgen secretion by suppressing the steroidogenic acute regulatory protein(StAR).Given that StAR facilitates cholesterol to testosterone conversion,AMPK inhibits this process by modulating cholesterol transport and suppressing StAR expression through multiple avenues.Furthermore,adiponectin-induced PPARαactivation impedes mitochondrial cholesterol influx,further modulating androgen biosynthesis.The suppressive influence of PPARαon steroidogenic genes,notably StAR,is evident.Collectively,adiponectin signalling predominantly attenuates androgen production,ensuring metabolic and reproductive equilibrium.Imbalances,as seen in conditions like hypogonadism and obesity-related infertility,highlight their crucial roles and potential clinical interventions for reproductive disorders.

关 键 词：ADIPONECTIN TESTOSTERONE Steroidogenic acute regulatory protein Steroidogenesis Leydig cells 

分 类 号：R285[医药卫生—中药学]