Study on the Correlation between Adiponectin and Bone Mineral Density in Postmenopausal Women from Guangxi Zhuang Autonomous Region  

作　　者：Ying Li Peizhao Shi Songyi Mo Jiahui Li Xinling Ma Ziyang Fang Lingling Huang Ruiqun Lu Jinhua Wang Ying Li;Peizhao Shi;Songyi Mo;Jiahui Li;Xinling Ma;Ziyang Fang;Lingling Huang;Ruiqun Lu;Jinhua Wang(School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, China;Affiliated Hospital of Hebei University of Engineering, Handan, China;Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, China)

机构地区：[1]School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, China [2]Affiliated Hospital of Hebei University of Engineering, Handan, China [3]Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, China

出　　处：《Journal of Biosciences and Medicines》2024年第5期178-189,共12页生物科学与医学（英文）

摘　　要：Objectives: To explore the relationship between adiponectin (APN) and bone mineral density in this Zhuang ethnic group, thus providing a basis underpinning the prevention and treatment of osteoporosis (OP). Methods: Zhuang women over 50 years old in Guangxi Zhuang Autonomous Region were included in the study. The broadband ultrasound attenuation (BUA) was adopted as the reference to calculate the T value. Quantitative ultrasonic bone density was measured on the right. Body composition measuring instrument was used to measure weight, fat, and muscle mass. Plasma APN level was detected by ELISA and blood lipids were detected by enzymatic method. Results: Plasma APN level was found with significant differences in the normal bone mineral density group, bone mineral density reduction group, and osteoporosis group (P β = −0.176, P = 0.001) when the partial correlation coefficient of APN is −0.210. Elevated APN was an independent risk factor for bone mineral density reduction (OR = 1.191, 95%CI: 1.004 - 1.407, P = 0.04) and OP (OR = 1.1337, 95%CI: 1.137 - 1.572, P Conclusion: Increased APN in postmenopausal women of Zhuang is an independent risk factor for OP. The application of APN in the OP screening and prevention of middle-aged and ageing Zhuang women still needs further research.Objectives: To explore the relationship between adiponectin (APN) and bone mineral density in this Zhuang ethnic group, thus providing a basis underpinning the prevention and treatment of osteoporosis (OP). Methods: Zhuang women over 50 years old in Guangxi Zhuang Autonomous Region were included in the study. The broadband ultrasound attenuation (BUA) was adopted as the reference to calculate the T value. Quantitative ultrasonic bone density was measured on the right. Body composition measuring instrument was used to measure weight, fat, and muscle mass. Plasma APN level was detected by ELISA and blood lipids were detected by enzymatic method. Results: Plasma APN level was found with significant differences in the normal bone mineral density group, bone mineral density reduction group, and osteoporosis group (P β = −0.176, P = 0.001) when the partial correlation coefficient of APN is −0.210. Elevated APN was an independent risk factor for bone mineral density reduction (OR = 1.191, 95%CI: 1.004 - 1.407, P = 0.04) and OP (OR = 1.1337, 95%CI: 1.137 - 1.572, P Conclusion: Increased APN in postmenopausal women of Zhuang is an independent risk factor for OP. The application of APN in the OP screening and prevention of middle-aged and ageing Zhuang women still needs further research.

关 键 词：POSTMENOPAUSAL OSTEOPOROSIS ADIPONECTIN Broadband Ultrasound Attenuation 

分 类 号：R58[医药卫生—内分泌]