RUXOLITINIB

作品数：36被引量：66H指数：5
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相关领域：医药卫生更多>>
相关作者：刘贵敏梁文同成志勇张丽军李晓菲更多>>
相关机构：保定市第一医院承德医学院复旦大学哈尔滨医科大学更多>>
相关期刊：《Cellular & Molecular Immunology》《药学进展》《透析与人工器官》《World Journal of Hematology》更多>>
相关基金：国家自然科学基金河北省科学技术研究与发展计划项目保定市科技局科学技术研究与发展指导计划项目卫生部卫生公益性行业科研专项更多>>
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Ruxolitinib plus steroids for acute graft versus host disease:a multicenter,randomized,phase 3 trial
《Signal Transduction and Targeted Therapy》2024年第11期5286-5296,共11页Liping Dou Yanli Zhao Jingjing Yang Lei Deng Nan Wang Xiawei Zhang Qingyang Liu Yan Yang Zhijie Wei Fuxu Wang Yifan Jiao Fei Li Songhua Luan Liangding Hu Sujun Gao Chuanfang Liu Xiangjun Liu Jinsong Yan Xuejun Zhang Fang Zhou Peihua Lu Daihong Liu 
supported by grants from the National Key R&D Program of China(2023YFC2507800,2021YFA1100904);the National Natural Science Foundation of China(Nos.82270162,82270224,82200169);the Beijing Natural Science Foundation of China(No.7222175);the Military medical support innovation and generate special program(21WQ034);the Special Research Found for Health Protection(21BJZ30);Beijing Nova Program cross-cutting Project(20230484407);the Logistics Independent Research Program(2023hqzz09);Capital’s Funds for Health Improvement and Research(2024-2-5063).
Newly diagnosed patients with high-risk acute graft-versus-host disease(aGVHD)often experience poor clinical outcomes and low complete remission rates.Ruxolitinib with corticosteroids showed promising efficacy in impr...
关键词：RANDOMIZED STEROIDS CONFIDENCE 
Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury被引量：1
《Neural Regeneration Research》2024年第11期2499-2512,共14页Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao 
supported by the National Natural Science Foundation of China,No.82272484(to XC).
The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arth...
关键词：astrocytes EAAT2 EXCITOTOXICITY glutamate homeostasis JAK-STAT pathway locomotor function NEUROTOXICITY RUXOLITINIB spinal cord injury transcriptome analysis 
Does Ruxolitinib, in Comparison to Best Available Therapy (BAT), Improve Pruritis Symptoms in Patients with Polycythemia Vera?
《Journal of Biosciences and Medicines》2024年第3期35-43,共9页Zachary Samuel Thorogood 
Polycythemia vera manifests as a myeloproliferative neoplasm associated with diverse symptoms, including aquagenic pruritis. This systematic review addresses the pressing need to enhance the understanding of the dise...
关键词：Polycythemia Vera RUXOLITINIB Pruritis 
Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
《Blood Science》2023年第4期258-268,共11页Huijun Huang Jinqin Liu Lin Yang Yiru Yan Meng Chen Bing Li Zefeng Xu Tiejun Qin Shiqiang Qu Liang Wang Gang Huang Yue Chen Zhijian Xiao 
Supported in part by Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00033);CAMS Initiative Fund for Medical Sciences(Nos.2022-I2M-1-022);Clinical Research Fund of National Clinical Research Centre for Blood Diseases(Nos.2023NCRCA0117 and 2023NCRCA0103);National Natural Science Funds(Nos.82170139,82104785,82070134 and 81530008).
Ruxolitinib is a cornerstone of management for some subsets of myeloproliferative neoplasms(MPNs);however,a considerable number of patients respond suboptimally.Here,we evaluated the efficacy of micheliolide(MCL),a na...
关键词：Micheliolide Myeloproliferative neoplasms RUXOLITINIB STAT3/5 Suboptimal response 
The opposite impact of Janus kinase inhibitor Ruxolitinib on the function of bone marrow mesenchymal stem cells and immune cells in acute GVHD recipients
《Blood Science》2023年第4期277-279,共3页Defu Zeng 
Allogeneic hematopoietic cell transplantation(Allo-HCT)is a curative therapy for hematologic malignancies owing to graft-versus-leukemia/lymphoma(GVL)activity mediated by alloreactive donor T cells,but graft-versus-ho...
关键词：ORGANS GVHD IMPACT 
Risk of hepatitis B reactivation in patients with myeloproliferative neoplasms treated with ruxolitinib
《World Journal of Hepatology》2023年第11期1188-1195,共8页Adeniyi Abraham Adesola Matei-Alexandru Cozma Yong-Feng Chen Bahadar Singh Srichawla Mihnea-Alexandru Găman 
Competitiveness Operational Programme(COP)A1.1.4.ID:P_37_798 MYELOAL-EDIAPROT,No.149/26.10.2016,(MySMIS2014+:106774).
Classical Philadelphia-negative myeloproliferative neoplasms(MPNs),i.e.,polycythemia vera,essential thrombocythemia,and primary/secondary myelofibrosis,are clonal disorders of the hematopoietic stem cell in which an u...
关键词：RUXOLITINIB Myeloproliferative neoplasms Hepatitis B Polycythemia vera MYELOFIBROSIS JAK inhibitor 
Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression被引量：2
《Cellular & Molecular Immunology》2022年第10期1130-1140,共11页Tihong Shao Patrick S.C.Leung Weici Zhang Koichi Tsuneyama William M.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari M.Eric Gershwi 
This work is supported in part by the National Institutes of Health grant DK123262(MEG);federal funds directly from the intramural research programs of the NCI,CCR,Laboratory of Cancer Immunometabolism under Contract No.HHSN261200800001E(HAY);TS’s fellowship is supported in part by an award(#81871296)from the National Natural Science Foundation of China.
The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity.We have generated a unique murine model named ARE-Del,with chronic overexpressio...
关键词：Primary biliary cholangitis AUTOIMMUNITY INTERFERONS Janus Kinase Inhibitors RUXOLITINIB 
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury被引量：6
《Neural Regeneration Research》2022年第9期2029-2035,共7页Zhan-Yang Qian Ren-Yi Kong Sheng Zhang Bin-Yu Wang Jie Chang Jiang Cao Chao-Qin Wu Zi-Yan Huang Ao Duan Hai-Jun Li Lei Yang Xiao-Jian Cao 
supported by the National Natural Science Foundation of China,Nos.81871773(to XJC),81672152(to XJC),81802149(to LY);Primary Research and Development Plan of Jiangsu Province of China,No.BE2018132(to XJC);Scientific Research Project of Health Commission of Jiangsu Province of China,No.LGY2020068(to HJL).
Excessive inflammation post-traumatic spinal cord injury(SCI)induces microglial activation,which leads to prolonged neurological dysfunction.However,the mechanism underlying microglial activation-induced neuroinflamma...
关键词：functional recovery glial scar inflammation INTERFERON-Γ JAK/STAT signaling MICROGLIA RUXOLITINIB spinal cord injury 
Turner syndrome with primary myelofibrosis,cirrhosis and ovarian cystic mass:A case report
《World Journal of Clinical Cases》2022年第9期2931-2937,共7页Lin-Wei Xu Yong-Zhong Su Hong-Fang Tao 
BACKGROUND Turner syndrome(TS)with leukemia is a complicated clinical condition.The clinical course and outcome of these patients are poor,so the treatment and prognosis of TS with hematological malignancies deserve o...
关键词：Turner syndrome Primary myelofibrosis CIRRHOSIS Ovarian cystic mass RUXOLITINIB Case report 
Successful resolution of hemophagocytic lymphohistiocytosis during the chemotherapy course of acute myelocytic leukemia with ruxolitinib
《Chinese Medical Journal》2022年第2期237-239,共3页Yue Song Jingshi Wang Xinkai Wang Yini Wang Zhao Wang 
This work was supported by the National Natural Science Foundation of China(No.81871633).
To the Editor:Hemophagocytic lymphohistiocytosis(HLH)is a severe or even fatal inflammatory condition.Malignant HLH(M-HLH)is one of the most common types of secondary HLH(sHLH),especially in adults.HLH can occur eithe...
关键词：CHEMOTHERAPY HISTIOCYTOSIS phagocytic 
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