BACKGROUND The programmed cell death protein 1 inhibitor pembrolizumab has become a key treatment for various cancers,including triple-negative breast cancer.However,it is associated with immune-related adverse events...
BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following transplant.Intravenous immunoglobulin(IVIG)pla...
Acute respiratory distress syndrome(ARDS),a fatal critical disease,is induced by various insults.ARDS represents a major global public health burden,and the management of ARDS continues to challenge healthcaresystems ...
A multitude of bioactive compounds are produced by the gut microbiota,including metabolites with notable antimicrobial or immunomodulatory effects.Perhaps the most compelling of these compounds,however,are the ones wi...
supported by grants from the National Key R&D Program of China(2023YFC2507800,2021YFA1100904);the National Natural Science Foundation of China(Nos.82270162,82270224,82200169);the Beijing Natural Science Foundation of China(No.7222175);the Military medical support innovation and generate special program(21WQ034);the Special Research Found for Health Protection(21BJZ30);Beijing Nova Program cross-cutting Project(20230484407);the Logistics Independent Research Program(2023hqzz09);Capital’s Funds for Health Improvement and Research(2024-2-5063).
Newly diagnosed patients with high-risk acute graft-versus-host disease(aGVHD)often experience poor clinical outcomes and low complete remission rates.Ruxolitinib with corticosteroids showed promising efficacy in impr...
BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell ca...
Supported by Jiangsu Province Chinese Medicine Science and Technology Development Program,No.ZT202119.
BACKGROUND Endoscopic submucosal dissection(ESD)is a reliable method to resect early esophageal cancer.Esophageal stricture is one of the major complications after ESD of the esophagus.Steroid prophylaxis for esophage...
BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory response.Dexamethasone,a synthetic glucocorticoid,exerts ...
BACKGROUND Acute liver failure(ALF)may be the first and most dramatic presentation of Wilson’s disease(WD).ALF due to WD(WD-ALF)is difficult to distinguish from other causes of liver disease and is a clear indication...
supported by the National Key Research and Development Program of China(No.2021YFA0910500);the National Natural Science Foundation of China(No.U22A20380 and 82104043);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Science and Technology Major Project of Hubei Province(No.2021ACA012).
Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus spectabilis.Their structures and absolute configurations were determined using a combination of high-resolut...