云南高校图书馆联盟文献共享服务平台- HETEROGENEITY

HETEROGENEITY: 作品数：892被引量：1908H指数：16; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：狄宁宁庞浩鹏冯晓源任彦姚振威更多>>; 相关机构：中国石油大学（北京）复旦大学中国石油中国石油大学(北京)更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi; supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).; Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...; 关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis: 《Neural Regeneration Research》2025年第7期2013-2014,共2页Nathanael J.Lee Ryota L.Matsuoka; supported by funding from the National Institutes of Health(R01 NS117510)(to RLM)。; Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose a...; 关键词：ANGIOGENESIS HOMEOSTASIS network

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma: 《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang; supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).; Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...; 关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping

Heterogeneity of mature oligodendrocytes in the central nervous system: 《Neural Regeneration Research》2025年第5期1336-1349,共14页Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel; supported by a grant from the Progressive MS Alliance(BRAVE in MS);Le Grand Portage Fund。; Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functio...; 关键词：aging central nervous system diseases electron microscopy HETEROGENEITY immunohistochemistry myelin sheath natural history NEUROGLIA OLIGODENDROGLIA single-cell gene expression analysis

Triplet therapy overcomes 3rd-EGFR TKl-resistant EGFR-L858R/T790M/C797S in trans and in cis/L718Q mutation: 《Genes & Diseases》2025年第2期1-3,共3页Kaibo Ding Zhongsheng Peng Yanjun Xu; supported by the Natural Scientific Foundation of Zhejiang Province,China (No.LTGY23H160007).; Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over t...; 关键词：heterogeneity. LUNG OVERCOME

Strike-slip Fault Architecture and its Control on Fractured Carbonate Reservoirs:Insight from Outcrops in the North-western Tarim Basin,NW China: 《Acta Geologica Sinica(English Edition)》2025年第2期568-581,共14页YAO Yingtao ZENG Lianbo MAO Zhe SONG Yichen TAN Xiaolin LIN Bo LIU Guoping CAO Dongsheng Mehdi OSTADHASSAN ZHANG Qiao LI Hao; supported by the National Natural Science Foundation of China(Grant No.U21B2062).; Recent exploration has highlighted the critical role of strike-slip faults in shaping ultra-deep carbonate reservoirs in the Tarim Basin.This study integrates satellite imagery,UAV photogrammetry,outcrop surveys and m...; 关键词：strike-slip fault carbonate reservoir fault zone heterogeneity reservoir physical properties Tarim Basin

Engineering heterogeneous microstructures for enhanced strength and ductility in air-cooled Al−Mg−Si alloys: 《Transactions of Nonferrous Metals Society of China》2025年第4期1017-1031,共15页Yi-han GAO Xin-xin ZHANG Jing-zhe ZHOU Peng XU Zhi-jie XIN Jun-hua GAO Yan-hao SHI You LÜ Yu-fang ZHAO Jing-yang LI; supported by the National Natural Science Foundation of China(Nos.52301025,52371065,52301179);the Fundamental Research Program of Shanxi Province,China(Nos.202203021222039,202203021212124)。; The heterogeneity ofα-Al(Fe,Mn)Si dispersoids andβ″precipitates was tuned to enhance the strength−ductility synergy of air-cooled Al−Mg−Si alloys.Scanning electron microscopy(SEM)and transmission electron microscop...; 关键词：Al−Mg−Si alloy microstructure heterogeneity DISPERSOID nanoprecipitate mechanical property

Advancing skeletal health and disease research with single-cell RNA sequencing: 《Military Medical Research》2025年第2期285-310,共26页Peng Lin Yi-Bo Gan Jian He Si-En Lin Jian-Kun Xu Liang Chang Li-Ming Zhao Jun Zhu Liang Zhang Sha Huang Ou Hu Ying-Bo Wang Huai-Jian Jin Yang-Yang Li Pu-Lin Yan Lin Chen Jian-Xin Jiang Peng Liu; National Key Research and Development Program of China(2022YFA1103202);National Natural Science Foundation of China(82272507,32270887,and 32200654);Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDJO008);Postdoctoral Innovative Talent Support Program(BX20220397);Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning(SFLKF202201);Project for Enhancing Innovation of Army Medical University(2023X1839);Talent Innovation Training Program at the Army Medical Center(ZXZYTSYS09);General Hospital of Western Theater Command Research Project(2021-XZYG-B10);University Grants Committee,Research Grants Council of Hong Kong,China(14113723,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。; Orthopedic conditions have emerged as global health concerns,impacting approximately 1.7 billion individuals worldwide.However,the limited understanding of the underlying pathological processes at the cellular and mol...; 关键词：Skeletal disorders Musculoskeletal system Single-cell RNA sequencing(scRNA-seq) Cellular heterogeneity Single cell suspension Bioinformatic analysis

Local chemical heterogeneity enabled superior zero thermal expansion in nonstoichiometric pyrochlore magnets: 《National Science Review》2025年第3期245-254,共10页Yanming Sun Ruohan Yu Sergii Khmelevskyi Kenichi Kato Yili Cao Shixin Hu Maxim Avdeev Chin-Wei Wang Chengyi Yu Qiang Li Kun Lin Xiaojun Kuang Xianran Xing; supported by the National Key R&D Program of China(2020YFA0406202);the National Natural Science Foundation of China(22275015 and 22090042);the Fundamental Research Funds for the Central Universities,China(FRF-EYIT-23-03 a nd FRF-IDRY-23-020).; The design of zero thermal expansion(ZTE)materials is urgently required as dimension-stable components in widespread modern high-precision technologies.Local chemical order has been of great importance in engineering ...; 关键词：zero thermal expansion PYROCHLORE magnetic structure local composition heterogeneity

Production Networks and Business Cycles in China: 《China Finance and Economic Review》2025年第1期3-22,共20页Yiping Huang Shiyu Xu Changhua Yu Haofeng Du Harry Xiaoying Wu; Business cycles are often regarded as aggregate phenomena.However,against the backdrop of rapid structural transformation in Chinese economy,they are also influenced by cyclical changes in various sectors and the evol...; 关键词：business cycles sectoral shocks production networks heterogeneity restriction.Bavessiian structuralvectorautoregression

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

HETEROGENEITY

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

HETEROGENEITY

检索结果分析

下载全文

用户登录

高级检索检索式检索