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Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites
《Neural Regeneration Research》2025年第9期2645-2654,共10页Kirsty Goncalves Stefan Przyborski 
supported by a BBSRC CASE training studentship,No.BB/K011413/1(to KG)。
Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's disease.The accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed t...
关键词：Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron NOGO Rho A ROCK stem cell three-dimensional culture 
Triplet therapy overcomes 3rd-EGFR TKl-resistant EGFR-L858R/T790M/C797S in trans and in cis/L718Q mutation
《Genes & Diseases》2025年第2期1-3,共3页Kaibo Ding Zhongsheng Peng Yanjun Xu 
supported by the Natural Scientific Foundation of Zhejiang Province,China (No.LTGY23H160007).
Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over t...
关键词：heterogeneity. LUNG OVERCOME 
SLFN11 Deficiency-Induced Gemcitabine Resistance Is Overcome by Agents Targeting the DNA Damage Response in Pancreatic Cancer Cells
《BIOCELL》2025年第4期681-700,共20页Jae Hyeong Kim Yuna Youn Jin-Hyeok Hwang 
supported by the 8th AstraZeneca-KHIDI(Korea Health Industry Development Institute)oncology research program;a research grant was supported by AstraZeneca and by Grant No.02-2022-0020 from the Seoul National University Hospital(SNUBH)Research Fund.
Objectives:SLFN11(Schlafen-11)enhances sensitivity to DNA-damaging agents(DDAs)and DNA damage response(DDR)inhibitors in various cancer types.However,its function in pancreatic cancer(PC)remains largely unknown.This r...
关键词：SLFN11 DNA-damaging agents DNA damage response pancreatic cancer 
Robots Ready to Serve Humans Humanoid robots are set to go into mass production as industry works to overcome technological bottlenecks
《ChinAfrica》2025年第4期58-59,共2页LIU XUEYUN 
A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular...
关键词：SERVE Spring OVERCOME 
Reply to the“Discussion on“Data-driven Methods to Predict the Burst Strength of Corroded Line Pipelines Subjected to Internal Pressure”by Jie Cai et al.https://doi.org/10.1007/s11804-022-00263-0”
《哈尔滨工程大学学报(英文版)》2025年第1期252-253,共2页Jie Cai 
With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burs...
关键词：al. OVERCOME utilizing 
Construction of a lightweight, bispecific human antibody based on the bovine nano knob domain
《Science China(Life Sciences)》2025年第3期877-879,共3页Siling Wang Yizhen Wang Xiuting Chen Wenling Jiang Zheng Chen Huixian Shang Zhiyong Li Zizheng Zheng Ningshao Xia 
supported by the National Natural Science Foundation of China(81991491,32300777);the Fundamental Research Funds for the Central Universities(20720220006);China Postdoctoral Science Foundation(2022M722659);CAMS Innovation Fund for Medical Sciences(2019RU022).
Dear Editors,Bispecific antibodies(bsAbs),which possess the unique ability to bind to two different antigens simultaneously(Labrijn et al.,2019),have emerged as powerful tools in the field of cancer immunotherapy and ...
关键词：offering OVERCOME PAIRING 
Expert consensus on apical microsurgery
《International Journal of Oral Science》2025年第1期1-9,共9页Hanguo Wang Xin Xu Zhuan Bian Jingping Liang Zhi Chen Benxiang Hou Lihong Qiu Wenxia Chen Xi Wei Kaijin Hu Qintao Wang Zuhua Wang Jiyao Li Dingming Huang Xiaoyan Wang Zhengwei Huang Liuyan Meng Chen Zhang Fangfang Xie Di Yang Jin Zhao Yihuai Pan Shuang Pan Deqin Yang Weidong Niu Qi Zhang Shuli Deng Jingzhi Ma Xiuping Meng Jian Yang Jiayuan Wu Yi Du Junqi Ling Lin Yue Xuedong Zhou Qing Yu 
Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general...
关键词：MICROSURGERY PREVENTION OVERCOME 
Allogeneic hematopoietic stem cell transplantation could overcome the poor prognosis of DNMT3A^(mut)NPM1^(mut)FLT3-ITD^(mut)in acute myeloid leukemia:real-world multicenter analysis in China
《Frontiers of Medicine》2025年第1期90-100,共11页Wenxuan Huo Yifan Shen Jiayu Huang Yang Yang Shuang Fan Xiaosu Zhao Qi Wen Luxiang Wang Chuanhe Jiang Yang Cao Xiaodong Mo Yang Xu Xiaoxia Hu 
supported by the National Key Research and Development Program of China(Nos.2022YFC2502600 and 2022YFC2502606);the National Natural Science Foundation of China(Nos.82170206 and 82170208);CAMS Innovation Fund for Medical Sciences(Nos.2019-I2M-5-034 and 2022-I2M-C&T-B-121);Peking University People’s Hospital Research and Development Funds(No.RZ2022-02);Tongzhou District Distinguished Young Scholars(No.JCQN2023009);Shanghai Municipal Health Commission Project of Disciplines of Excellence(No.20234Z0002)。
The cooccurrence of NPM1,FLT3-ITD,and DNMT3A mutations(i.e.,triple mutation)is related to dismal prognosis in patients with acute myeloid leukemia(AML)receiving chemotherapy alone.In this multicenter retrospective coh...
关键词：allogeneic hematopoietic stem cell transplantation acute myeloid leukemia DNMT3A mutation NPMI mutation FLT3-ITD mutation triple mutation 
Guiding ASEAN to New Horizons in 2025 Malaysia’s leadership in strengthening ASEAN-China ties for regional prosperity
《China Report ASEAN》2025年第2期46-46,共1页Liow Tiong Lai 
Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China ...
关键词：strengthening mutual OVERCOME 
Tumor microenvironment-responsive drug self-delivery systems to treat cancer and overcome MDR
《Rare Metals》2025年第1期1-33,共33页Ling-Mei Li Yi-Pin Xie Yu-Rong Qin Hai-Ping Chu Hui Xie De-Jin Zang Teng Liu 
supported by the National Natural Science Foundation of China(No.21907059);Shandong Province Chinese Medicine Science and Technology Development Project(No.M-2022258);the Young Scientist Development Foundation of Shandong First Medical University(No.202201-002);the Academic Promotion Program of Shandong First Medical University(Nos.2019LJ003 and 2019QL011).
Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs t...
关键词：Drug self-delivery system Metal drug Tumor microenvironment response Drug carrier Tumor multidrug resistance 
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