supported by a grant from the Progressive MS Alliance(BRAVE in MS);Le Grand Portage Fund。
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functio...
supported by projects NDG09/014 and Proyecto VEXEM(to CLP),European Social Fund,YEI,(Nos.PEJ16/MED/AI-1153 and PEJD-2018-PRE/SAL-8532)of the Community of Madrid,Spain;SAF-2016-78666-R,CP19-0010,and PID 2020-113014RB-I00 funded by MCIN/AEI/10.13039/501100011033(to JARN).
Cell replacement therapy has long been proposed as a treatment for the damaged nervous system.One of the most challenging aspects of such a strategy,however,is finding sources of donor cells for transplantation.Autolo...
supported by the Ministry of Science and Technology of China(2021ZD0201700);the National Natural Science Foundation of China(31921003).
Astrocytes(ASTs)and oligodendroglial lineage cells(OLGs)are major macroglial cells in the central nervous system.ASTs communicate with each other through connexin(Cx)and Cx-based network structures,both of which allow...
This work was in part supported by grants from the NIH(R01NS102382,R01NS122108,and R01AG073779 to P.J.).
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells ...
Supported by Fondo Sectorial de Investigación para la Educación(FSIE SEP/CONACyT)to MV-T,No.287115;Fondo Sectorial de Investigación en Salud y Seguridad Social(FOSISS SS/IMSS/ISSSTE-CONACyT)to BC,No.261459.
Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%.Both disorders present chronic and deteriorating prognoses that impose a large burden,not only on ...
supported by the National Natural Science Foundation of China ( 81100897 and 81100926 );the Natural Science Foundation of Chongqing Municipality, China (cstc2011jj A0856)
Increasing evidence suggests that white matter disorders based on myelin sheath impairment may underlie the neuropathological changes in schizophrenia.But it is unknown whether enhancing remyelination is a beneficial ...
supported by NIH grants NS070526 and NS056097 to YF,and NS070526-01A1S1 to MDM;ANB and MDM were supported by NIH training grant T32GM008602
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conductio...
Since loss of oligodendrocytes and consequent demyelination of spared axons severely impair the functional recovery of injured spinal cord, it is reasonably expected that the reduction of oligodendroglial death and en...