Rise of the human-mouse chimeric brain models  

作　　者：Peng Jiang Mahabub Maraj Alam 

机构地区：[1]Department of Cell Biology and Neuroscience,Rutgers University,604 Allison Road,Piscataway,NJ 08854,USA

出　　处：《Cell Regeneration》2022年第1期333-336,共4页细胞再生（英文）

基　　金：This work was in part supported by grants from the NIH(R01NS102382,R01NS122108,and R01AG073779 to P.J.).

摘　　要：Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain.This provides new opportunities to understand human brain development and neurological disorders.

关 键 词：Human pluripotent stem cells CHIMERA Macroglia ASTROGLIA OLIGODENDROGLIA MICROGLIA Neurons Neurological Disorders 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]