CHIMERA

作品数：104被引量：137H指数：6
导出分析报告
相关领域：医药卫生更多>>
相关作者：仝艳李晓飞李晓晓张玲娜张新华更多>>
相关机构：河南中医药大学第四军医大学中国海洋大学深圳市迪欧迪电子贸易有限公司更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目北京市自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Physical mechanisms of human brain functions
《Quantitative Biology》2025年第1期1-27,共27页Zonghua Liu 
National Natural Science Foundation of China,Grant/Award Numbers:11835003,12175070;STI2030-Major Projects,Grant/Award Number:2021ZD0202600。
In recent years,exploring the physical mechanisms of brain functions has been a hot topic in the fields of nonlinear dynamics and complex networks,and many important achievements have been made,mainly based on the cha...
关键词：chimera states eigenmode analysis network synchronization remote firing propagation remote synchronization 
“Chimera+MolAICal”软件在药物化学教学中的应用——伊马替尼与蛋白酪氨酸激酶的分子对接
《化学教育(中英文)》2025年第4期99-107,共9页臧青民 章烨雯 蒋德旗 吴桂卓 
2024年度广西职业教育教学改革研究项目(GXGZJG2024B269)《新质生产力背景下应用型创新人才的培养模式的探索与实践——以玉林师范学院制药工程专业为例》;2023年广西高等教育本科教学改革项目(2023JGB328)《新高考导向之地方生物师范生“三习贯通”实践教学体系构建研究与实践》;2022年玉林师范学院“四新”研究与实践项目(2022xjsx01)《新工科背景下“精药强工”的制药工程课程体系构建与实践》。
探讨了Chimera和MolAICal软件在药物化学教学中的应用。传统药物化学教学往往受限于理论知识的抽象性和学生实践经验的匮乏,故难以有效地培养学生的理解能力和应用能力。为了解决这一问题,将Chimera与MolAICal软件相结合,应用于药物化...
关键词：MolAICal CHIMERA 伊马替尼 蛋白酪氨酸激酶 分子对接 药物化学教学 
Targeted degradation of membrane and extracellular proteins with LYTACs
《Acta Pharmacologica Sinica》2025年第1期1-7,共7页Yu-yang Li Yang Yang Ren-shuai Zhang Rui-xin Ge Song-bo Xie 
This work was supported by the National Natural Science Foundation of China(32270892 and 32070708);Henan Province Key Research and development and promotion special(Science and technology research):No.242102311036.
Targeted protein degradation technology has gained substantial momentum over the past two decades as a revolutionary strategy for eliminating pathogenic proteins that are otherwise refractory to treatment.Among the va...
关键词：targeted protein degradation lysosome targeting chimera lysosome-trafficking receptor extracellular protein membraneprotein 
46,XX/46,XY Chimera with Ovotesticular Disorder of Sex Development (OT-DSD): A Rare Entity
《Open Journal of Genetics》2024年第4期77-86,共10页Mama Sy Chérif Mouhamed Dial Racha Ibondou Abdoulaye Séga Diallo Abdoulaye Ba Oumar Faye 
Ovotesticular disorder of sex development (OT-DSD) is a condition in which, both testicular tissue and ovarian tissue are co-existent in the same gonad (ovotestis) or independently in separate gonads characterizing th...
关键词：Ovotestis-Disorder of Sex Development-DSD-Chimera HYPOSPADIAS 
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
《Acta Pharmacologica Sinica》2024年第11期2267-2276,共10页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang 
supported by the National Natural Science Foundation of China(No.82230041,91949205);Sanming Project of Medicine in Shenzhen(No.SZSM202211010);Guangdong Provincial Key S&T Program(No.2018B030336001),Peking University Talent Startup Fund(No.BMU2022YJ003);supported by the“Fundamental Research Funds for the Central Universities”,Scientific Project of Beijing Life Science Academy(No.2024300CC0020).
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,including Alzheimer’s disease(AD).We have recently conceptualized the desi...
关键词：TAU dephosphorylation targeting chimera(DEPTAC) TAUOPATHY Alzheimer’s disease drug development 
Author Correction:A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
《Acta Pharmacologica Sinica》2024年第11期2453-2454,共2页Jing-fen Su Yue Xiao Lin-yu Wei Hui-yang Lei Fei Sun Wei-xia Wang Shi-hong Li Xiao-chuan Wang Jie Zheng Jian-zhi Wang 
Correction to:Acta Pharmacologica Sinica(2024)0:1-10;https://doi.org/10.1038/s41401-024-01326-4,published online 02 July 2024 The authors would like to apologize for the errors in the previously published images of Fi...
关键词：checked FIGURES FUSED 
Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
《Neuroscience Bulletin》2024年第9期1315-1332,共18页Yanru Ji Jenna Lillie McLean Ranjie Xu 
Human pluripotent stem cell(hPSC)models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific disease mechanisms.In particular,hPSC-based human–animal brain chimer...
关键词：Human pluripotent stem cell Human–animal chimera Neurological disorder Disease modeling Cell therapy Human neurons and glia MICROGLIA Organoid 
Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma
《Oncology Research》2024年第4期679-690,共12页XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU 
supported by the National Natural Science Foundation of China Fund Project(82272956).
Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expr...
关键词：Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) METASTASIS 
Targeted degradation of LRG1 to attenuate renal fibrosis被引量：1
《Asian Journal of Pharmaceutical Sciences》2024年第4期144-158,共15页Linyao Fan Yingqiu Qi Xi Yang Yarui Xu Yana Zhang Longdi Wang Anying Zhu Lirong Zhang Jian Song Shengnan Du Guangjun Nie Huan Min 
supported by grants from the National Natural Science Foundation of China(32000998,32201240,and 81700638);The Young Elite Scientists Sponsorship Program by the Henan Association for Science and Technology(2022HYTP046);the China Postdoctoral Science Foundation(2021TQ0298).
Leucine-richα-2 glycoprotein 1(LRG1),a secreted glycoprotein,has been identified as significantly upregulated in renal fibrosis,potentially exacerbating the condition by enhancing TGF-β-Smad3-dependent signaling pat...
关键词：LRG1 Renal fibrosis Proteolysis targeting chimera Targeting peptide 
Expanding the horizons of targeted protein degradation:A non-small molecule perspective
《Acta Pharmaceutica Sinica B》2024年第6期2402-2427,共26页Xiaowei Huang Fengbo Wu Jing Ye Lian Wang Xiaoyun Wang Xiang Li Gu He 
supported by grants from the National Natural Science Foundation of China(22177084,82273559,82103757 and 82073473);the China Postdoctoral Science Foundation(2022M722283);PostDoctor Research Project,West China Hospital,Sichuan University(2023HXBH076,China);Sichuan Natural Science Foundation Project(2023NSFSC1554,China);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21036,China).
Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized...
关键词：Targeted protein degradation Proteolysis targeting chimera ENDOCYTOSIS Autophagy Proximity-inducing modality Post-translational modification 
全选清除导出
共11页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部