ASTROGLIA

作品数:14被引量:20H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:高向东姚文兵吴梧桐更多>>
相关机构:中国药科大学更多>>
相关期刊:《Genes & Diseases》《Neural Regeneration Research》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《中国药科大学学报》更多>>
相关基金:国家自然科学基金更多>>
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Rise of the human-mouse chimeric brain models
《Cell Regeneration》2022年第1期333-336,共4页Peng Jiang Mahabub Maraj Alam 
This work was in part supported by grants from the NIH(R01NS102382,R01NS122108,and R01AG073779 to P.J.).
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells ...
关键词:Human pluripotent stem cells CHIMERA Macroglia ASTROGLIA OLIGODENDROGLIA MICROGLIA Neurons Neurological Disorders 
Glial cells in intracerebral transplantation for Parkinson’s disease被引量:1
《Neural Regeneration Research》2020年第7期1173-1178,共6页Nikola Tomov 
In the last few decades,intracerebral transplantation has grown from a dubious neuroscientific topic to a plausible modality for treatment of neurological disorders.The possibility for cell replacement opens a new fie...
关键词:ASTROGLIA DOPAMINERGIC glial scarring MICROGLIA NEUROINFLAMMATION Parkinson's disease TRANSPLANTATION 
The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy被引量:5
《Journal of Clinical and Translational Hepatology》2019年第4期352-361,共10页Victoria Jaeger Sharon DeMorrow Matthew McMillin 
This study was funded by a VA Career Development award(BX003486)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Matthew McMillin.This study was also funded by NIH R01 awards(DK082435 and DK112803);a VA Merit award(BX002638)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Sharon DeMorrow.This work was also supported by the resources of the Central Texas Veterans Health Care System Research Service,Temple,Texas.The content is t
Hepatic encephalopathy is a neurological complication result-ing from loss of hepatic function and is associated with poor clinical outcomes.During acute liver failure over 20%of mortality can be associated with the d...
关键词:Acute liver failure MICROGLIA NEUROINFLAMMATION Ammonia ASTROGLIA 
Ellagic acid supports neurons by regulating astroglia nuclear factor erythroid 2-related factor 2
《中国药理学与毒理学杂志》2019年第6期450-450,共1页WANG Guo-qing HE Xue-mei ZHU Guo-fu LI Dai-di SHI Jing-shan ZHANG Feng 
OBJECTIVE Astroglia support neurons by providing substrates for neuronal metabolism, glutamate clearance and anti-oxidant protection. Nuclear factor erythroid 2-related factor 2(Nrf2) is the main switch of intracellul...
关键词:ellagic acid ASTROGLIA NRF2 NEUROTROPHIC effects 
Synthetic cell pathobiology to study neurodegeneration: defining new therapeutic targets in astroglia被引量:1
《Neural Regeneration Research》2016年第2期234-235,共2页Matjaz Stenovec: Robert Zorec 
supported by the Slovenian Research Agency grants P3310,J3 3632,J3 4051,J3-4146,J3 6790,J3 7605
Synthetic biology is the design and construction of new biological parts,devices,and systems,and the re-design of existing,natural biological systems for useful purposes.This new interdisciplinary effort has gained in...
Adult neurogenesis: Is it showtime for clinical translation?
《Genes & Diseases》2015年第4期291-292,共2页Yu-Jie Lai Fei Sun Guo-Jun Chen 
This work was supported by NSFC grants(81220108010 and 81171197)to GC and a NIH grant(HL096800)to FS.
The existence of adult stem cells was first described in tissues with high proliferation rates,such as the hematopoietic system and the intestine.Since then,stem cells have been found in almost all adult tissues,inclu...
关键词:Adult neurogenesis ASTROGLIA B1 cells Multipotent neural stem cells(NSCs) Neurological disorders 
Microglia and astroglia:the role of neuroinflammation in lead toxicity and neuronal injury in the brain被引量:1
《Neuroimmunology and Neuroinflammation》2015年第1期131-137,共7页Jin-Tao Liu Mo-Han Dong Jie-Qiong Zhang Ya Bai Fang Kuang Liang-Wei Chen 
Lead(Pb^(2+)),a ubiquitous environmental toxicant,may widely affect the function of many organs or systems of human beings,especially the brain.Although lead is believed to transport into the brain through the blood-b...
关键词:ASTROGLIA BRAIN lead toxicity MICROGLIA NEUROINFLAMMATION 
Effects of fluctuating glucose concentrations on oxidative metabolism of glucose in cultured neurons and astroglia被引量:1
《Journal of Diabetes Mellitus》2012年第1期19-26,共8页Shinichi Takahashi Takato Abe Yoshikane Izawa Norihiro Suzuki 
The objective of the present study was to evaluate the effects of hyperglycemia on glucose metabolism of brain cells. Not only a sustained hyperglycemic state, but also a fluctuating plasma glucose concentration has b...
关键词:Astrocyte Diabetic ENCEPHALOPATHY HYPERGLYCEMIA [14C]acetate [14C]deoxyglucose [14C]lactate [14C]pyruvate 
Cilostazol Enhances Oxidative Glucose Metabolism in Both Neurons and Astroglia without Increasing Ros Production
《Pharmacology & Pharmacy》2011年第4期315-321,共7页Shinichi Takahashi Yoshikane Izawa Norihiro Suzuki 
Cilostazol, a potent inhibitor of type 3 phosphodiesterase (PDE3), has recently been reported to exert neuroprotective effects during acute cerebral ischemic injury. These effects are, at least in part, mediated by th...
关键词:ASTROCYTE CILOSTAZOL Glucose LACTATE PYRUVATE DEHYDROGENASE 
Recent advances in (patho)physiology of astroglia被引量:6
《Acta Pharmacologica Sinica》2010年第9期1044-1054,共11页Alexei VERKHRATSKY Vladimir PARPURA 
Authors research was supported by Alzheimer's Research Trust (UK) Programme Grant (ART/PG2004A/1) to AV; by National Institute of Health (NIH) grant to VP (R01 MH 069791); by National Science Foundation (CBET 0943343) grant to VP, by the Grant Agency of the Czech Republic (GACR 305/08/1381 and GACR 305/08/1384) to AV.
Our view of astrocytes in the operation of the brain is changing dramatically over the last 3 decades. Astroglial calcium excitability controls the release of gliotransmitters, which can occur at the tripartite synaps...
关键词:NEUROGLIA ASTROCYTE gliotransmission NEUROPATHOLOGY NEURODEGENERATION 
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