This work was in part supported by grants from the NIH(R01NS102382,R01NS122108,and R01AG073779 to P.J.).
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo.Chimeric mouse brains have been created by engrafting human fetal tissue-or pluripotent stem cell-derived progenitor cells ...
In the last few decades,intracerebral transplantation has grown from a dubious neuroscientific topic to a plausible modality for treatment of neurological disorders.The possibility for cell replacement opens a new fie...
This study was funded by a VA Career Development award(BX003486)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Matthew McMillin.This study was also funded by NIH R01 awards(DK082435 and DK112803);a VA Merit award(BX002638)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Sharon DeMorrow.This work was also supported by the resources of the Central Texas Veterans Health Care System Research Service,Temple,Texas.The content is t
Hepatic encephalopathy is a neurological complication result-ing from loss of hepatic function and is associated with poor clinical outcomes.During acute liver failure over 20%of mortality can be associated with the d...
OBJECTIVE Astroglia support neurons by providing substrates for neuronal metabolism, glutamate clearance and anti-oxidant protection. Nuclear factor erythroid 2-related factor 2(Nrf2) is the main switch of intracellul...
supported by the Slovenian Research Agency grants P3310,J3 3632,J3 4051,J3-4146,J3 6790,J3 7605
Synthetic biology is the design and construction of new biological parts,devices,and systems,and the re-design of existing,natural biological systems for useful purposes.This new interdisciplinary effort has gained in...
This work was supported by NSFC grants(81220108010 and 81171197)to GC and a NIH grant(HL096800)to FS.
The existence of adult stem cells was first described in tissues with high proliferation rates,such as the hematopoietic system and the intestine.Since then,stem cells have been found in almost all adult tissues,inclu...
Lead(Pb^(2+)),a ubiquitous environmental toxicant,may widely affect the function of many organs or systems of human beings,especially the brain.Although lead is believed to transport into the brain through the blood-b...
The objective of the present study was to evaluate the effects of hyperglycemia on glucose metabolism of brain cells. Not only a sustained hyperglycemic state, but also a fluctuating plasma glucose concentration has b...
Cilostazol, a potent inhibitor of type 3 phosphodiesterase (PDE3), has recently been reported to exert neuroprotective effects during acute cerebral ischemic injury. These effects are, at least in part, mediated by th...
Authors research was supported by Alzheimer's Research Trust (UK) Programme Grant (ART/PG2004A/1) to AV; by National Institute of Health (NIH) grant to VP (R01 MH 069791); by National Science Foundation (CBET 0943343) grant to VP, by the Grant Agency of the Czech Republic (GACR 305/08/1381 and GACR 305/08/1384) to AV.
Our view of astrocytes in the operation of the brain is changing dramatically over the last 3 decades. Astroglial calcium excitability controls the release of gliotransmitters, which can occur at the tripartite synaps...