NEUROTROPHIC

作品数:140被引量:573H指数:14
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相关领域:医药卫生更多>>
相关作者:史建刚贾连顺李家顺谭俊铭王玉杏更多>>
相关机构:第二军医大学解放军第98医院河北医科大学第二医院河北医科大学更多>>
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相关基金:国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划俄罗斯基础研究基金更多>>
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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology
《Neural Regeneration Research》2025年第9期2655-2666,共12页Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang 
supported by the National Key R&D Program of China,No.2021YFA0805200(to SY);the National Natural Science Foundation of China,No.31970954(to SY);two grants from the Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(both to XJL)。
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r...
关键词:androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor 
Luteolin,a common flavone in vegetables,acts as a hormetin possessing neurotrophic function:signaling mediated by inducing mitochondrial stress
《Food Science and Human Wellness》2025年第2期569-580,共12页Alex Xiong Gao Tracy Chenxi Xia Maggie Suisui Guo Gary Kawing Yuen Kevin Qiyun Wu Tina Tingxia Dong Karl Wah-Keung Tsim 
supported by Hong Kong RGC-GFC 16100921;Hong Kong RGC Theme-based Research Scheme(T13-605/18-W);Hong Kong Innovation Technology Fund(PRP/076/20FXITCPD/17-9,MHP/004/21);PD18SC01 and HMRF18SC06;HMRF20SC07,AFD20SC01;Shenzhen Science and Technology Innovation Committee(ZDSYS201707281432317)。
This study aims to uncover the hormetic process of luteolin,a common dietary flavone,in neuronal cells through its role in inducing mitochondrial stress.In rat pheochromocytoma PC12 cells,luteolin at low concentration...
关键词:Flavonoids HORMESIS Mitochondrial membrane potential Autophagy MITOPHAGY 
Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report
《World Journal of Clinical Cases》2025年第2期39-49,共11页Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young Kwon Sojin Shin 
Supported by Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,funded by the Ministry of Health&Welfare,Republic of Korea,No.RS-2022-KH129889.
BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic diagnostics.Data on neurotrophic tyrosine recept...
关键词:Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report 
Hydrogel dressings on neurotrophic keratitis in an experimental animal model
《International Journal of Ophthalmology(English edition)》2024年第8期1396-1402,共7页Hua-Qin Xia Xiao-Dan Jiang Yi-Fan Song Xue-Min Li Yan-Jie Tian 
Supported by the Beijing Natural Science Foundation (No.7202229).
AIM:To investigate the therapeutic effects of hydrogel dressings on neurotrophic keratitis in rats.METHODS:Male Wistar rats,aged 42–56d,were randomly divided into control,experimental,and treatment groups,each consis...
关键词:neurotrophic keratitis HYDROGEL corneal epithelial cells RAT 
Chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor for neurotrophic keratopathy
《Neural Regeneration Research》2024年第3期680-686,共7页Jie Wu Yulei Huang Hanrui Yu Kaixiu Li Shifeng Zhang Guoqing Qiao Xiao Liu Hongmei Duan Yifei Huang Kwok-Fai So Zhaoyang Yang Xiaoguang Li Liqiang Wang 
supported by PLA General Hospital Program,No.LB20201A010024(to LW).
Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of etiologies.The treatment options for neurotrophic ker...
关键词:chitosan corneal reinnervation murine nerve growth factor neurotrophic keratopathy thermosensitive hydrogel 
Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?被引量:1
《Neural Regeneration Research》2024年第3期536-541,共6页Georges Jourdi Samuel Fleury Imane Boukhatem Marie Lordkipanidzé 
Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical symptoms.The p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve deve...
关键词:Alzheimer’s disease amyotrophic lateral sclerosis BIOMARKER DEMENTIA diabetic neuropathy nerve growth factor receptor(NGFR) NEURODEGENERATION p75^(NTR) schizophrenia 
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
《Signal Transduction and Targeted Therapy》2024年第3期1147-1164,共18页Yan Guo Pan Xiang Xiaojiao Sun Wei Liu Jiafeng Zhou Bin Yin Lin Hou Boqin Qiang Huiliang Li Pengcheng Shu Xiaozhong Peng 
supported by grants from the National Natural Science Foundation of China(32370883);National Science and Technology Innovation 2030 Grants(2021ZD0200902);the CAMS Innovation Fund for Medical Sciences(CIFMS;2021-I2M-1-019 and 2021-I2M-1-024).
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules...
关键词:IMPAIRED restrain PERIPHERAL 
DNA Methyltransferase Inhibitors Induce Cerebral Dopamine Neurotrophic Factor Expression in C6 Glioma Cells
《American Journal of Molecular Biology》2023年第3期170-182,共13页Sumeya Z. Mukhtar Lennard P. Niles 
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) are involved in neuroprotection and mitigating endoplasmic reticulum (ER) stress in the brain and peripheral ...
关键词:CDNF MANF 5-AZACYTIDINE 5-Aza-2’-deoxycytidine ZEBULARINE Gene Expression 
Corneal neurotization: a narrative review of techniques, outcomes, and surgical considerations
《Annals of Eye Science》2023年第2期1-13,共13页Jessica Zhang Anne Barmettler 
Background and Objective:Corneal neurotization is a novel surgical technique used to restore corneal sensation in patients with neurotrophic keratopathy.Neurotrophic keratopathy is a disorder characterized by dysfunct...
关键词:Corneal neurotization neurotrophic keratopathy corneal sensation neurotrophic cornea 
Paradigm shift of chemotherapy and systemic treatment for biliary tract cancer
《World Journal of Gastrointestinal Oncology》2023年第6期959-972,共14页Wattana Leowattana Tawithep Leowattana Pathomthep Leowattana 
Biliary tract cancers(BTC)are frequently identified at late stages and have a poor prognosis due to limited systemic treatment regimens.For more than a decade,the combination of gemcitabine and cis-platin has served a...
关键词:Biliary tract cancers Gemcitabine and cisplatin combination Fibroblast growth factor receptor 2 inhibitors Isocitrate dehydrogenase 1 inhibitors Neurotrophic tyrosine receptor kinase gene fusion inhibitors Immune checkpoint inhibitors Microsatellite instability high Infrigatinib Pemigatinib 
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