Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?  

作　　者：Georges Jourdi Samuel Fleury Imane Boukhatem Marie Lordkipanidzé 

机构地区：[1]Research Center,Montreal Heart Institute,Montreal,QC,Canada [2]Faculty of Pharmacy,Universitéde Montréal,Montreal,QC,Canada [3]UniversitéParis Cité,INSERM,Innovative Therapies in Haemostasis,Paris,France [4]Service d’Hématologie Biologique,AP-HP,Hôpital Lariboisière,Paris,France

出　　处：《Neural Regeneration Research》2024年第3期536-541,共6页中国神经再生研究（英文版）

摘　　要：Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical symptoms.The p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and maturation.Its cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and urine.There is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic neuropathy.Whether p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open question.In this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative diseases.We also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关 键 词：Alzheimer’s disease amyotrophic lateral sclerosis BIOMARKER DEMENTIA diabetic neuropathy nerve growth factor receptor(NGFR) NEURODEGENERATION p75^(NTR) schizophrenia 

分 类 号：R741[医药卫生—神经病学与精神病学]