DOPAMINERGIC

作品数：112被引量：288H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：蔡定芳孙珊陈依萍李文伟高俊鹏更多>>
相关机构：复旦大学江西中医药大学中国科学院上海生命科学研究院北京理工大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>
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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy被引量：1
《Neural Regeneration Research》2025年第3期887-899,共13页Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen 
supported by the National Natural Science Foundation of China,Nos.82271283(to XC),91854115(to JW),31970044(to JW);the Natural Science Foundation of Beijing,No.7202001(to XC);the Scientific Research Project of Beijing Educational Committee,No.KM202010005022(to XC)。
Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environme...
关键词：ALKBH5 AUTOPHAGY FTO Hippo pathway m~6A Parkinson's disease RNA methylation SALSOLINOL YAP1 YTHDF2 
Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice:Evaluation of a novel Parkinsonian mouse model
《Zoological Research》2025年第1期225-235,共11页Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-Juan Liu Jun-Xia Xie 
supported by the National Natural Science Foundation of China (32471049,32170984,32471188,32200802);Natural Science Foundation of Shandong Province (ZR2023QH110)。
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD),supporting the“body-first”hypothesis.However,there remains a notable absence of PD-specific ani...
关键词：Parkinson’s disease Mouse model CXCL1 Inflammation PPAR signaling pathway 
Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
《Neural Regeneration Research》2025年第1期93-106,共14页Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 
supported by the Research Project of the Shanghai Health Commission,No.2020YJZX0111(to CZ);the National Natural Science Foundation of China,Nos.82021002(to CZ),82272039(to CZ),82171252(to FL);a grant from the National Health Commission of People’s Republic of China(PRC),No.Pro20211231084249000238(to JW);Medical Innovation Research Project of Shanghai Science and Technology Commission,No.21Y11903300(to JG).
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism....
关键词：aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINSONISM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2 
Dopaminergic Remodeling During a Critical Developmental Window:Linking Drug Use to Adult Aggression
《Neuroscience Bulletin》2024年第6期845-848,共4页Dadao An Lingyan Zheng Zhengyi Xu Yanrong Zheng Zhong Chen 
supported by the STI2030-Major Projects(2021ZD0202800).
Behaviors can be shaped and modulated by the dopamine system,which can be remodeled in adolescents due to environmental factors,including pharmacologic exposure,stress,and rewarding experiences,leading to various adol...
关键词：WINDOW shaped DOPAMINE 
Cell senescence induced by toxic interaction betweenα-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson’s disease被引量：1
《Acta Pharmacologica Sinica》2024年第2期268-281,共14页Qing-qing Shen Xian-hui Jv Xi-zhen Ma Chong Li Lin Liu Wen-ting Jia Le Qu Lei-lei Chen Jun-xia Xie 
supported by grants from National Natural Science Foundation of China(32170984);Natura Science Foundation of Shandong Province(ZR2020YQ23,ZR2023QH110);Qingdao Postdoctoral Research Project(QDBSH20220202204).
Cell senescence has been implicated in the pathology of Parkinson’s disease(PD).Both abnormalα-synuclein aggregation and iron deposition are suggested to be the triggers,facilitators,and aggravators during the devel...
关键词：Parkinson’s disease cell senescence dopaminergic neurons Α-SYNUCLEIN IRON transferrin receptor 1 
Genetic analysis of transcription factors in dopaminergic neuronal development in Parkinson’s disease
《Chinese Medical Journal》2024年第4期450-456,共7页Yuwen Zhao Lixia Qin Hongxu Pan Tingwei Song Yige Wang Xiaoxia Zhou Yaqin Xiang Jinchen Li Zhenhua Liu Qiying Sun Jifeng Guo Xinxiang Yan Beisha Tang Qian Xu 
supported by grants from the National Natural Science Foundation of China(Nos.82071437,U20A20355,and 82101342);the Hunan Innovative Province Construction Project(No.2019SK2335);the Natural Science Foundations of Hunan Province(No.2021JJ31115);the National Key Research and Development Program of China(Nos.2016YFC1306000 and 2021YFC2502100);the Project Program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)(No.2021KFJJ10)
Background:Genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson’s disease(PD)risk factors;however,no comprehensive analyses of these genes in patients with PD have been u...
关键词：Parkinson’s disease Transcription factors Dopaminergic neurons GENETIC VARIANTS 
One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo被引量：1
《Neural Regeneration Research》2024年第2期458-464,共7页Lin Feng Da Li Yao Tian Chengshun Zhao Yun Sun Xiaolong Kou Jun Wu Liu Wang Qi Gu Wei Li Jie Hao Baoyang Hu Yukai Wang 
supported by the National Key Research and Development Program of China,Nos.2017YFE0122900(to BH),2019YFA0110800(to WL),2019YFA0903802(to YW),2021YFA1101604(to LW),2018YFA0108502(to LF),and 2020YFA0804003(to JW);the National Natural Science Foundation of China,Nos.31621004(to WL,BH)and 31970821(to YW);CAS Project for Young Scientists in Basic Research,No.YSBR-041(to YW);Joint Funds of the National Natural Science Foundation of China,No.U21A20396(to BH)。
Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a p...
关键词：axonal integrity cell cryopreservation cellular environment cellular niche cell replacement therapy dopaminergic progenitors human pluripotent stem cell mechanical damage neuronal cell delivery Parkinson’s disease small-aperture gelatin microcarriers 
A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease被引量：2
《Neural Regeneration Research》2024年第2期324-330,共7页Xi Chen Yuhu Zhang 
supported by the National Natural Science Foundation of China,No.82071419;Key Research and Development Program of Guangzhou,No.202206010086;High-level Hospital Construction Project,No.DFJH201907;Supporting Research Funds for Outstanding Young Medical Talents in Guangdong Province,No.KJ012019442(all to YZ)。
The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent bu...
关键词：anterior brain system CEREBELLUM CHOLINERGIC cognitive impairment DOPAMINERGIC dual syndrome hypothesis neuroimage NEUROTRANSMITTER Parkinson’s disease posterior brain system therapeutic targets 
The projection-specific signals that establish functionally segregated dopaminergic synapses
《四川生理科学杂志》2023年第9期1742-1742,共1页Akiko Terauchi 
Dopaminergic projections regulate various brain functions and are implicated in many neuropsychiatric disorders. There are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to...
关键词：PROJECTION MOTIVATION SPECIFIC 
Correction:Starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
《Translational Neurodegeneration》2023年第1期574-574,共1页Xavier Sánchez-Sáez† Isabel Ortuño-Lizarán† Carla Sánchez-Castillo Pedro Lax Nicolás Cuenca 
Correction:Translational Neurodegeneration(2023)12:17(2023)https://doi.org/10.1186/s40035-023-00348-y Following publication of the original article[1],the authors reported an error in the article title.Following publi...
关键词：DEGENERATE motion LOOSE 
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