supported by the Natural Science Foundation in Xinjiang Uygur Autonomous Region(Urumqi,China,2023D01F38).
Objective:To observe the effect of Xipayimaizibizi oral liquid(XP)in an overactive bladder(OAB)experimental rat model and to explore its pharmacological mechanisms.Methods:Network pharmacology was used to explore the ...
Shanghai Municipal Committee of Science and Technology(Code 20Z11900800).
Background and objective The injury of the cholinergic white matter pathway underlies cognition decline in patients with silent cerebrovascular disease(SCD)with white matter hyperintensities(WMH)of vascular origin.How...
supported by grants from the Ministry of Science and Technology of China(2021ZD0203204);the National Natural Science Foundation of China(32030052 and 31530028).
Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the...
supported by the National Natural Science Foundation of China(82071231(CX),81971038(CYZ),82171235(CYZ),82271293(CX),82371242(CYZ));the Fund for Jiangsu Province Specially Appointed Professor(CX,CYZ);the Natural Science Foundation of Jiangsu Province(BK20211349,CYZ);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJA320006(CYZ),23KJA320007,(CX));the Leadership Program in Xuzhou Medical University(JBGS202203,CX).
Nicotinic acetylcholine receptors(nAChRs)regulate pain pathways with various outcomes depending on receptor subtypes,neuron types,and locations.But it remains unknown whetherα4β2 nAChRs abundantly expressed in the s...
Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional processing.Interneurons not only provide modulation to the basal ganglia circuitry und...
Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular junction.The primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChRs),which results in qualitative...
supported by the National Natural Science Foundation of China,No.82071419;Key Research and Development Program of Guangzhou,No.202206010086;High-level Hospital Construction Project,No.DFJH201907;Supporting Research Funds for Outstanding Young Medical Talents in Guangdong Province,No.KJ012019442(all to YZ)。
The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent bu...
Butyrylcholinesterase(BChE;EC 3.1.1.8),an enzyme structurally related to acetylcholinesterase,is widely distributed in the human body.It plays a role in the detoxification of chemicals such as succinylcholine,a muscle...
Objective To observe the effect of electroacupuncture(EA)at"Neiguan"(PC 6)on myocardial fibrosis in spontaneously hypertensive rats(SHR),and explore preliminarily the mediating role of cholinergic antiinflammatory pat...
DearEditor,Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has led to>6 million deaths and posed a huge threat to the global economy and public health....