CHOLINERGIC

作品数:113被引量:323H指数:9
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相关领域:医药卫生更多>>
相关作者:张麟胡大一李静张均田段文贞更多>>
相关机构:北京大学首都医科大学附属北京朝阳医院中国医学科学院北京协和医学院中国中医研究院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金霍英东教育基金更多>>
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Mechanism of action of Xipayimaizibizi oral liquid on outlet obstruction-induced overactive bladder:An integrated study
《Journal of Traditional Chinese Medical Sciences》2025年第1期86-99,共14页Menglu Wang Yang Yang Yuhang Du Jiamei Xie Yige Zhao Yongcheng An Ziyi Shan Shenyujun Wang Meng Hao Baosheng Zhao 
supported by the Natural Science Foundation in Xinjiang Uygur Autonomous Region(Urumqi,China,2023D01F38).
Objective:To observe the effect of Xipayimaizibizi oral liquid(XP)in an overactive bladder(OAB)experimental rat model and to explore its pharmacological mechanisms.Methods:Network pharmacology was used to explore the ...
关键词:Xipayimaizibizi oral liquid Overactive bladder Partial bladder outlet obstruction Muscarinic receptor Cholinergic synapse Calcium signaling pathway 
Intelligent cholinergic white matter pathways algorithm based on U-net reflects cognitive impairment in patients with silent cerebrovascular disease
《Stroke & Vascular Neurology》2024年第6期699-707,共9页Beini Fei Yu Cheng Ying Liu Guangzheng Zhang Anyan Ge Junyi Luo Shan Wu He Wang Jing Ding Xin Wang 
Shanghai Municipal Committee of Science and Technology(Code 20Z11900800).
Background and objective The injury of the cholinergic white matter pathway underlies cognition decline in patients with silent cerebrovascular disease(SCD)with white matter hyperintensities(WMH)of vascular origin.How...
关键词:CHOLINERGIC PATIENTS impairment 
Modulating the Pronociceptive Effect of Sleep Deprivation:A Possible Role for Cholinergic Neurons in the Medial Habenula
《Neuroscience Bulletin》2024年第12期1811-1825,共15页Xiang-Sha Yin Bai-Rong Chen Xi-Chun Ye Yun Wang 
supported by grants from the Ministry of Science and Technology of China(2021ZD0203204);the National Natural Science Foundation of China(32030052 and 31530028).
Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the...
关键词:Medial habenula CHOLINERGIC Sleep deprivation Pronociceptive effect HYPERALGESIA 
α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata
《Acta Pharmacologica Sinica》2024年第6期1160-1174,共15页Yu Han Jia-qi Zhang Ya-wei Ji Yi-wen Luan Shu-yi Li Hui-zhen Geng Ying Ji Cui Yin Su Liu Chun-yi Zhou Cheng Xiao 
supported by the National Natural Science Foundation of China(82071231(CX),81971038(CYZ),82171235(CYZ),82271293(CX),82371242(CYZ));the Fund for Jiangsu Province Specially Appointed Professor(CX,CYZ);the Natural Science Foundation of Jiangsu Province(BK20211349,CYZ);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJA320006(CYZ),23KJA320007,(CX));the Leadership Program in Xuzhou Medical University(JBGS202203,CX).
Nicotinic acetylcholine receptors(nAChRs)regulate pain pathways with various outcomes depending on receptor subtypes,neuron types,and locations.But it remains unknown whetherα4β2 nAChRs abundantly expressed in the s...
关键词:PAIN cholinergic system nicotinic acetylcholine receptor substantia nigra pars reticulata pedunculopontine nucleus chronic nicotine 
The dual role of striatal interneurons:circuit modulation and trophic support for the basal ganglia被引量:3
《Neural Regeneration Research》2024年第6期1277-1283,共7页Elliot Wegman Marlena Wosiski-Kuhn Yu Luo 
Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional processing.Interneurons not only provide modulation to the basal ganglia circuitry und...
关键词:CHOLINERGIC dopamine GABAERGIC INTERNEURON levodopa-induced dyskinesia PARVALBUMIN sonic hedgehog STRIATUM trophic factor 
Perioperative cardiac risks in myasthenia gravis被引量:1
《World Journal of Clinical Cases》2024年第13期2147-2150,共4页Deb Sanjay Nag Abhishek Chatterjee Pratap Rudra Mahanty Merina Sam Murari Kumar Bharadwaj 
Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular junction.The primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChRs),which results in qualitative...
关键词:Myasthenia Gravis Perioperative period RECEPTORS CHOLINERGIC ANESTHESIA 
A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease被引量:3
《Neural Regeneration Research》2024年第2期324-330,共7页Xi Chen Yuhu Zhang 
supported by the National Natural Science Foundation of China,No.82071419;Key Research and Development Program of Guangzhou,No.202206010086;High-level Hospital Construction Project,No.DFJH201907;Supporting Research Funds for Outstanding Young Medical Talents in Guangdong Province,No.KJ012019442(all to YZ)。
The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent bu...
关键词:anterior brain system CEREBELLUM CHOLINERGIC cognitive impairment DOPAMINERGIC dual syndrome hypothesis neuroimage NEUROTRANSMITTER Parkinson’s disease posterior brain system therapeutic targets 
Emerging significance of butyrylcholinesterase被引量:1
《World Journal of Experimental Medicine》2024年第1期33-43,共11页Gumpeny R Sridhar Lakshmi Gumpeny 
Butyrylcholinesterase(BChE;EC 3.1.1.8),an enzyme structurally related to acetylcholinesterase,is widely distributed in the human body.It plays a role in the detoxification of chemicals such as succinylcholine,a muscle...
关键词:ESTERASE ACETYLCHOLINESTERASE Variant CHOLINERGIC Metabolic syndrome Cognition Knockout model 
Effect of electroacupuncture on myocardial fibrosis in spontaneously hypertensive rats based on cholinergic anti-inflammatory pathway
《China Medical Abstracts(Internal Medicine)》2023年第4期194-195,共2页辛娟娟 
Objective To observe the effect of electroacupuncture(EA)at"Neiguan"(PC 6)on myocardial fibrosis in spontaneously hypertensive rats(SHR),and explore preliminarily the mediating role of cholinergic antiinflammatory pat...
关键词:HYPERTENSIVE CHOLINERGIC RATS 
Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells
《Journal of Molecular Cell Biology》2023年第7期73-76,共4页Jing Wen Jing Sun Yanhong Tang Jincun Zhao Xiao Su 
DearEditor,Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has led to>6 million deaths and posed a huge threat to the global economy and public health....
关键词:ACE2 LUNG INFECTION 
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