Perioperative cardiac risks in myasthenia gravis  

作　　者：Deb Sanjay Nag Abhishek Chatterjee Pratap Rudra Mahanty Merina Sam Murari Kumar Bharadwaj 

机构地区：[1]Department of Anaesthesiology,Tata Main Hospital,Jamshedpur 831001,India [2]Department of Anaesthesiology,Manipal Tata Medical College,Jamshedpur 831017,India

出　　处：《World Journal of Clinical Cases》2024年第13期2147-2150,共4页世界临床病例杂志

摘　　要：Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular junction.The primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChRs),which results in qualitative and quantitative reductions in the availability of functional AChRs.Cardiac muscles are also affected,resulting in various perioperative cardiac complications.Antistriational antibodies are commonly reported in MG cases with cardiac involvement.In the presence of thymoma,the prevalence of cardiac manifestations in patients with MG increases to approximately 10%-15%.Cardiac involvement in MG may range from asymptomatic electrocardiogram changes to ventricular tachycardia,myocarditis,conduction disorders,heart failure,and sudden death.Increased incidence of atrial fibrillation,ventricular and supraventricular extra systoles,and prolonged QTc have also been reported in patients with MG.Clinicians should consider the evaluation of autonomic dysfunction and risk of cardiovascular disease in patients with MG.

关 键 词：Myasthenia Gravis Perioperative period RECEPTORS CHOLINERGIC ANESTHESIA 

分 类 号：R746.1[医药卫生—神经病学与精神病学]