HYPERALGESIA

作品数：73被引量：293H指数：9
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相关领域：医药卫生更多>>
相关作者：戴甲培裴磊林传友殷光甫赵志奇更多>>
相关机构：中国科学院上海生命科学研究院华中科技大学北京大学第一医院第四军医大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Modulating the Pronociceptive Effect of Sleep Deprivation:A Possible Role for Cholinergic Neurons in the Medial Habenula
《Neuroscience Bulletin》2024年第12期1811-1825,共15页Xiang-Sha Yin Bai-Rong Chen Xi-Chun Ye Yun Wang 
supported by grants from the Ministry of Science and Technology of China(2021ZD0203204);the National Natural Science Foundation of China(32030052 and 31530028).
Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the...
关键词：Medial habenula CHOLINERGIC Sleep deprivation Pronociceptive effect HYPERALGESIA 
Influence of Surgical Incision Size and Interleukin 6 in the Occurrence of Postoperative Hyperalgesia in Lubumbashi/DR Congo
《Open Journal of Anesthesiology》2024年第11期232-247,共16页Christian Tshisuz-Nawej Nadine Kibwe Felly Kazadi Berenice Kamba Ruffin Nyembo Cédric Sangwa Patient Kayoyo Eric Kasamba Sebastien Mbuyi Claude Mwamba-Mulumba Berthe Barahyga Adelin Muganza Iteke Fefe Willy Arung 
Background: It appeared that the conjunction inflammation and nerve damage (caused by surgery) generate the hyperalgesic component. But the probability of predicting hyperalgesia from the size of the surgical incision...
关键词：Postoperative Hyperalgesia Prevalence Surgical Incision Size Interleukin 6 
Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice
《Fundamental Research》2024年第4期820-828,共9页Xiaqing Ma Qi Qi Wenying Wang Min Huang Haiyan Wang Limin Luo Xiaotao Xu Tifei Yuan Haibo Shi Wei Jiang Tao Xu 
the National Natural Science Foundation of China(82171486);Natural Science Foundation of Shanghai to T.X.(21ZR1448400);the Interdisciplinary Program of Shanghai Jiao Tong University to T.X.(YG2021ZD23);General Science Foundation of Shanghai Sixth People's Hospital to T.X.(YNMS202114);the Young Scholarship Program of the National Natural Science Foundation of China to Xiaqing Ma(82201366)and by Shanghai Sailing Program(21YF1434200).
The activation of spinal astrocytes accounts for opioid-induced hyperalgesia(OIH),but the underlying mechanisms remain elusive.The presence of astrocyte-neuron lactate shuttle(ANLS)makes astrocytes necessary for some ...
关键词：Pyruvate dehydrogenase kinase 4 Phosphorylated pyruvate dehydrogenase Astrocyte-neuron lactate shuttle Opioid-induced hyperalgesia LACTATE 
Intraplantar Injection of Monosodium Iodoacetate Produces Hyperalgesia in Rats and the Mechanism Underlying the Effect
《Journal of Biosciences and Medicines》2024年第6期244-254,共11页Sha-Sha Li Tian-Yun Yao Dan Wu Li-Ting Nan Shuang-Quan Yu 
Objective: To observe the effect of intraplantar injection of monosodium iodoacetate (MIA) on pain perception in rats and to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) in the effect....
关键词：TRPV1 Monosodium Iodoacetate CAPSAZEPINE HYPERALGESIA 
PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson’s disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons
《Acta Pharmacologica Sinica》2023年第12期2418-2431,共14页Li-guo Dong Meng-qi An Han-ying Gu Li-ge Zhang Jin-bao Zhang Cheng-jie Li Cheng-jie Mao Fen Wang Chun-feng Liu 
the National Natural Science Foundation of China(82071420,82271279);Jiangsu Provincial Key R&D Program(BE2018658);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Pain is a common annoying non-motor symptom in Parkinson’s disease(PD)that causes distress to patients.Treatment for PD pain remains a big challenge,as its underlying mechanisms are elusive.Pituitary adenylate cyclas...
关键词：Parkinson’s disease HYPERALGESIA pituitary adenylate cyclase-activating polypeptide PAC1-R spinal cord dorsal horn sEPSCs 
Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice被引量：1
《Journal of Traditional Chinese Medicine》2023年第5期915-924,共10页HAN Shuai MAO Hua JIN Tingting YAN Rubing WANG Ziyi ZHANG Jie SHI Jianwen LIANG Yongxin 
Natural Science Foundation of Shandong Province:Mechanism of the Compound Huanglian Decoction Against Morphine Tolerance Based on Network Pharmacology and Microglia M1/M2 Pattern(No.ZR2023MH270)。
OBJECTIVE: To evaluate the effect of berberine on morphine analgesia, tolerance, and hyperalgesia. METHODS: Morphine-induced acute tolerance model: mice received intraperitoneal berberine at doses of 2.5, 5.0, and 10 ...
关键词：BERBERINE MORPHINE PAIN drug tolerance HYPERALGESIA 
Newborn with Giant Non-Involuting Congenital Hemangioma: Mechanisms of Allodynia, Hyperalgesia and Treatment
《Case Reports in Clinical Medicine》2023年第10期397-407,共11页Valeria Bachiocco Ilenia Casini Andrea Gentili 
In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale whi...
关键词：Pain Mechanisms ALLODYNIA HYPERALGESIA NEWBORN Treatment 
Exercise combined with administration of adipose-derived stem cells ameliorates neuropathic pain after spinal cord injury被引量：1
《Neural Regeneration Research》2023年第8期1841-1846,共6页Xing Cheng Gu-Ping Mao Wen-Jie Hu Zheng-Ran Yu Yi-Yang Xu Wei Chen Xiang Li Xiao-Lin Zeng Wen-Wu Zhang Jie-Wen Chen Yong Wan Le Wang 
supported in part by the National Natural Science Foundation of China,Nos.81971151(to YW),82201360(to XC),82102583(to LW),and 82202739(to GPM);China Postdoctoral Science Foundation,Nos.YJ20210208 and 2022M713592;Guangdong Basic and Applied Basic Research Foundation,China,No.2021A1515110188(to XC);the Natural Science Foundation of Guangdong Province,China,No.2020A1515010306(to LW);the Science and Technology Program of Guangzhou,China,No.202102020040(to LW)。
Experimental studies have shown that exercise and human adipose-derived stem cells(ADSCs)play positive roles in spinal cord injury(SCI).However,whether ADSCs and/or exercise have a positive effect on SCI-induced neuro...
关键词：adipose-derived stem cells ALLODYNIA EXERCISE glial fibrillary acidic protein HYPERALGESIA hypoalgesia ionized calcium-binding adapter molecule 1 motor function spinal cord injury 
Topical Calendula officinalis L.inhibits inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms
《Journal of Integrative Medicine》2023年第1期34-46,共13页Bárbara B.Garrido-Suárez Gabino Garrido Addis Bellma Menéndez Nelson Merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández 
This research was financed by the projects of Ministerio de Salud Pública(MINSAP)Cuba(No.0808001);Agencia Presidencial de Cooperación Internacional de Colombia(APC),Bilateral Program Cuba-Colombia,and Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)Chile(No.1130601).
Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory hypernociception.Methods Creams with different Ca concentrations were tested for their ability to...
关键词：Calendulaofficinalis L. Formalintest PAIN HYPERALGESIA Inflammation 
CYP1B1-derived epoxides modulate the TRPA1channel in chronic pain被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期68-81,共14页Lili Sun Jie Zhang Changshan Niu Cassandra E.Deering-Rice Ronald W.Hughen John G.Lamb Katherine Rose Kevin M.Chase Marysol Almestica-Roberts Markel Walter Eric W.Schmidt Alan R.Light Baldomero M.Olivera Christopher A.Reilly 
funded by the Department of Defense [W81XWH-17-1-0413, USA]。
Pain is often debilitating,and current treatments are neither universally efficacious nor without risks.Transient receptor potential(TRP)ion channels offer alternative targets for pain relief,but little is known about...
关键词：CYPIB1 Spinal nerve ligation EPOXIDES TRPA1 Calcium imaging HYPERALGESIA Chronic pain INFLAMMATION 
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