Newborn with Giant Non-Involuting Congenital Hemangioma: Mechanisms of Allodynia, Hyperalgesia and Treatment  

作　　者：Valeria Bachiocco Ilenia Casini Andrea Gentili Valeria Bachiocco;Ilenia Casini;Andrea Gentili(Anesthesia and Intensive Care Unit, S Orsola Hospital University of Bologna, Bologna, Italy;Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy)

机构地区：[1]Anesthesia and Intensive Care Unit, S Orsola Hospital University of Bologna, Bologna, Italy [2]Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy

出　　处：《Case Reports in Clinical Medicine》2023年第10期397-407,共11页临床医学病理报告（英文）

摘　　要：In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale which rates pain intensity. The baby presented signs of these pathological events over long periods of the disease. They may be attributed to the high amount of the nociceptive ligands in the hemangioma microenviroment and to the elevated concentration of TNF-alpha and IL-6 in the blood. For a long time, the pain was relieved by a combination of opioids, adjuvants and paracetamol, but also by thalidomide and unexpectedly by interferon alpha. A mechanism-based pain treatment needs to take into account the processes underlying pain and also the ongoing pathology.In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale which rates pain intensity. The baby presented signs of these pathological events over long periods of the disease. They may be attributed to the high amount of the nociceptive ligands in the hemangioma microenviroment and to the elevated concentration of TNF-alpha and IL-6 in the blood. For a long time, the pain was relieved by a combination of opioids, adjuvants and paracetamol, but also by thalidomide and unexpectedly by interferon alpha. A mechanism-based pain treatment needs to take into account the processes underlying pain and also the ongoing pathology.

关 键 词：Pain Mechanisms ALLODYNIA HYPERALGESIA NEWBORN Treatment 

分 类 号：R24[医药卫生—中医临床基础]