supported by COBRE(P30GM149367);the Puerto Rico Science&Technology Trust(2022-00125);MBRS-RISE Program(R25 GM061838);SC1GM144032 program(all to JDM)。
In addition to the loss of motor function,~60% of patients develop pain after spinal cord injury.The cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epice...
supported by grants from the National Natural Science Foundation of China(No.31371124);the Ministry of Education's Industry-University Cooperation Collaborative Education Project(No.202101099013,201802136084).
Cancer pain is one of the most common symptoms in patients with advanced cancer.In this study,we aimed to investigate the effects of the Mas-related gene C(MrgC)receptors on bone cancer pain.Mechanical withdrawal thre...
the National Natural Science Foundation of China(81971038,82071231,82171235,82271293,81870891);the Fund for Jiangsu Province Specially-Appointed Professor(C.X.,C.Z.);the Natural Science Foundation of Jiangsu Province(BK20211349);the Leadership Program in Xuzhou Medical University(JBGS202203).
In addition to the cardinal motor symptoms,pain is a major non-motor symptom of Parkinson's disease(PD).Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in P...
In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale whi...
supported by grants from the Ministry of Science and Technology of China(2021ZD0203302);the National Natural Science Foundation of China(32170996);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2021SHIBS0002);the Guangdong Science and Technology Committee(2019A1515010041,A2021319);the Shenzhen Innovation Committee of Science and Technology(ZDSYS20200811144002008);the Natural Science Foundation of Shenzhen University General Hospital(SUGH2018QD024);the Basic Research Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324100206017).
The chronic use of morphine and other opioids is associated with opioid-induced hypersensitivity(OIH)and analgesic tolerance.Among the different forms of OIH and tolerance,the opioid receptors and cell types mediating...
supported by grants from the Ministry of Science and Technology of China(2021ZD0203302);the National Natural Science Foundation of China(32170996,32060199);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2021SHIBS0002);the Guangdong Science and Technology Committee(2019A1515010041,A2021319);the Shenzhen Innovation Committee of Science and Technology(ZDSYS20200811144002008);the Shenzhen Science and Technology Innovation Committee(JCYJ20180302174233348).
Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain patients.Some peripheral injuries result in the development of bilateral MA,while...
supported in part by the National Natural Science Foundation of China,Nos.81971151(to YW),82201360(to XC),82102583(to LW),and 82202739(to GPM);China Postdoctoral Science Foundation,Nos.YJ20210208 and 2022M713592;Guangdong Basic and Applied Basic Research Foundation,China,No.2021A1515110188(to XC);the Natural Science Foundation of Guangdong Province,China,No.2020A1515010306(to LW);the Science and Technology Program of Guangzhou,China,No.202102020040(to LW)。
Experimental studies have shown that exercise and human adipose-derived stem cells(ADSCs)play positive roles in spinal cord injury(SCI).However,whether ADSCs and/or exercise have a positive effect on SCI-induced neuro...
the National Natural Science Foundation of China(82001190);Natural Sci⁃ence Foundation of Shandong Province(ZR2021LZY016);Natural Science Foundation of Shandong Province(ZR2020MH348);Science and Technology Foundation of Shandong Traditional Chinese Medicine(2020Q035)。
OBJECTIVE To investigate whether electroacupuncture(EA)ameliorates abnormal trigeminal neuralgia(TN)orofacial pain and anxiety-like behavior by altering synaptic plasticity in the hippocampus CA1.METHODS A mouse infra...
supported by the National Key Research and Development Program of China(2021ZD0203100);the National Natural Science Foundation of China(32025017,32121002,82171218,82101300,82101301);the CAS Project for Young Scientists in Basic Research(YSBR-013);the Youth Innovation Promotion Association CAS;the CAS Collaborative Innovation Program of Hefei Science Center(2021HSC-CIP013);the Fundamental Research Funds for the Central Universities(WK9100000030);the USTC Research Funds of the Double First-Class Initiative(YD9100002018);the Natural Science Foundation of Anhui Province(2208085J30,2008085 QC114);the Innovative Research Team of High level Local Universities in Shanghai。
Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain re...
Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological proced...