ANTINOCICEPTION

作品数：33被引量：50H指数：5
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相关领域：医药卫生更多>>
相关作者：陈蓓蕾于布为宋萍赵志奇刘新垣更多>>
相关机构：上海交通大学医学院附属瑞金医院复旦大学三峡大学中国科学院上海生命科学研究院更多>>
相关期刊：《Neural Regeneration Research》《中国药理通讯》《神经解剖学杂志》《Open Journal of Anesthesiology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception
《National Science Review》2024年第7期100-119,共20页Yan-Nong Dou Yuan Liu Wen-Qun Ding Qing Li Hua Zhou Ling Li Meng-Ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan Zou Anan Li Yan-Gang Sun 
supported by the National Science and Technology Innovation 2030 Major Program(2021ZD0204404);the National Natural Science Foundation of China(82271244,32221003);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the YangFan project(21YF1453200);supported by the Youth Innovation Promotion Association,Chinese Academy of Sciences(2022266);supported by New Cornerstone Science Foundation through the Xplorer prize.
Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain,but its underlying circuit mechanism remains largely unknown.Here,we showed that endogenous opioid antinociception required th...
关键词：endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome 
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
《Acta Pharmacologica Sinica》2022年第6期1372-1382,共11页Yuan-yuan Wei Yan Ma Song-yu Yao Ling-hui Kong Xiao Liu Jing-rui Chai Jing Chen Wei Li Yu-jun Wang Li-ming Shao Jing-gen Liu 
This research was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant XDA12040319 to JGL);National Natural Science Foundation of China(Grant 81773710 to YJW and 82030112 to JGL);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant 2017334 to YJW)。
SLL-039(N-cyclopropylmethyl-7α-4′-(N’-benzoyl)amino-phenyl-6,14-endoethano-tetrahydronorthebaine)and SLL-1206(N-cyclopropylmethyl-7α-3′-(p-methoxybenzyl)amino-phenyl-6,14-endoethano-tetrahydronorthebaine)are two ...
关键词：κ-opioid receptor agonist 45-expoxymorphinan ANTINOCICEPTION conditioned place aversion SEDATION U50488H morphine Nor-BNI β-FNA 
Design and synthesis of novel α-aminoamides derivatives as Nav1.7 inhibitors for antinociception
《Chinese Chemical Letters》2022年第3期1643-1646,共4页Dengqi Xue Yani Liu Yilin Zheng Heling Niu Liying Dong Xiangshuo Ouyang Siyu Song Denggao Zhang Qianwei Ge Kewei Wang Liming Shao 
Financial supports by National Natural Science Foundation of China (Nos. 82003565 and 81973162);the Science and Technology Commission of Shanghai Municipality (No. 20S11902300,China)。
Three novel series of α-aminoamides derivatives were designed and synthesized based on ralfinamide,and their Nav1.7 inhibitory activities were evaluated using manual patch clamp electrophysiology. Active compounds in...
关键词：α-Aminoamides Sodium channel Nav1.7 inhibitor Chronic pain ANALGESIA 
Cannabinoid CB_(2) receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice
《Asian Pacific Journal of Tropical Biomedicine》2021年第4期141-147,共7页Clarice C.V.Moura Rafaela S.dos Santos Lucienir P.Duarte Giovane Galdino 
supported by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior-Brasil(CAPES)(Finance Code 001)
Objective:To investigate the antinociceptive effect of tingenone on inflammatory pain,as well as and the involvement of the cannabinoid receptors type 2(CB2)and spinal microglia in this process.Methods:Male Swiss mice...
关键词：Tingenone ANTINOCICEPTION CB2 Cannabinoid receptor ENDOCANNABINOIDS MICROGLIA 
Intrathecal administration of neuronostatin induces an antinociceptive effect in a mouse visceral pain model
《Brain Science Advances》2020年第4期344-354,共11页Tingji Shao Shaobin Yang Peng Yu 
funded by the Natural Science Foundation of Gansu Province(Grant No.18JR3RA101);Youth Science and Technology Talents Lifting Project Foundation of Gansu Province;the Doctoral Launching Foundation of Northwest Normal University
Neuronostatin(NST)is a peptide encoded by the somatostatin gene that serves important physiological functions in diverse tissues.Previous studies have shown that intracerebroventricular administration of NST induces a...
关键词：neuronostatin ANTINOCICEPTION G-protein-coupled receptor 107 opioid receptor MORPHINE 
The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>
《World Journal of Neuroscience》2019年第3期138-152,共15页Priscila Medeiros Sylmara Esther Negrini-Ferrari Ana Carolina Medeiros Lais Leite Ferreira Josie Resende Torres da Silva José Aparecido da Silva Norberto Cysne Coimbra Renato Leonardo de Freitas 
Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological proced...
关键词：Peripheral Neuropathic PAIN CHRONIC PAIN Sciatic Nerve CHRONIC Constriction Injury Cold ALLODYNIA Primary Motor Cortex STIMULATION ANTINOCICEPTION 
Effect of Peptidase Inhibitors on Dynorphin A (1-17) or (1-13)-Induced Antinociception and Toxicity at Spinal Level
《Pharmacology & Pharmacy》2017年第2期33-51,共19页Mitsumasa Matsuda Masanobu Yoshikawa Takugi Kan Mariko Watanabe Junko Ajimi Shigeru Takahashi Masaaki Miura Kenji Ito Hiroyuki Kobayashi Toshiyasu Suzuki 
Our group has earlier demonstrated that three enzymes sensitive to peptidase inhibitors (PIs), amastatin (A)-, captopril (C)-, and phosphoramidon (P), played an important role in inactivation of enkephalins at the spi...
关键词：DYNORPHIN A PEPTIDASE Dynorphin-Converting Enzyme ANTINOCICEPTION ALLODYNIA 
Porcine diazepam-binding inhibitor and bovine diazepam-binding inhibitor affect morphine antinociception via different receptors
《Protein & Cell》2017年第2期140-143,共4页Yu-Zhen Chen Xiao-Cun Li Zhen-Quan Guo Li Zhou Zhuan Zhou Song-Ping Liang Cai-Hong Wu 
ACKNOWLEDGEMENTS We thank Dr. lain C Bruce for helpful comments on the manuscript. 77 and ZL were partially supported by grants from the National Basic Research Program （973 Program） （No. 2012CB518006）, and the National Natural Science Foundation of China （Grant Nos. 31228010, 31171026, 31100597, 31327901, 31221002, 31330024, 31400708, 31670843, 31521062, and SQ2011SF11B01041）. Yu-Zhen Chen, Xiao-Cun Li, Zhen-Quan Guo, Li Zhou, Zhuan Zhou, Song-vve no conflict of interest. This article does not contain any studies with human subjects performed by the any of the authors. All institutional and national guidelines for the care and use of laboratory animals were followed.
Opioid addiction is one of the top challenges for society, particularly in China. To fight it, the key is to reveal its underlying mechanisms. Among the strategies to overcome the mental damage caused by opioids, inve...
Role of opioid receptor heterodimerization in pain modulation and tolerance development
《World Journal of Pharmacology》2015年第1期144-159,共16页Annu Mudgal Santosh Pasha 
Supported by Council of Scientific and Industrial Research
Protein to protein interactions leading to homo/heteromerization of receptor is well documented in literature. These interactions leading to dimeric/oligomers formation of receptors are known to modulate their functio...
关键词：Opioid receptors Receptor heterodimers G-protein coupled receptors oligomerization G protein coupled receptors Opioid tolerance G-protein coupled receptors Allosteric regulation ANTINOCICEPTION 
Nitridergic Modulation of the Antinociceptive Activity of Rosuvastatin in Mice
《Pharmacology & Pharmacy》2014年第1期61-68,共8页Viviana Noriega Fernando Sierralta Juan Carlos Prieto Pilar Zanetta Hugo F. Miranda 
Statins, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase enzyme inhibitors, are lipid-lowering drugs, often used in the treatment of cardiovascular diseases (hyperlipidemia, atherosclerosis). It has been sho...
关键词：ANTINOCICEPTION ANTI-INFLAMMATION Algesiometer Assays ROSUVASTATIN L-NAME AMINOGUANIDINE 
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