DYNORPHIN

作品数：21被引量：26H指数：3
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相关领域：医药卫生更多>>
相关作者：黄矛宫泽辉由振东万兴旺李万亥更多>>
相关机构：第二军医大学军事医学科学院上海海洋大学北京大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《Pharmacology & Pharmacy》《Chinese Medical Sciences Journal》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Author Correction:Amygdala dynorphin/κopioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
《Acta Pharmacologica Sinica》2023年第5期1107-1108,共2页Gui-ying Zan Xiang Sun Yu-jun Wang Rui Liu Chen-yao Wang Wei-jia Du Liu-bin Guo Jing-rui Chai Qing-lin Li Zhi-qiang Liu Jing-gen Liu 
Correction to:Acta Pharmacologica Sinica,https://doi.org/10.1038/s41401-021-00677-6,published online 25 May 2021 The authors apologized for two mistakes in the figures:(1)in Fig.4c,the representative traces of mouse l...
关键词：behavior FIGURES MISTAKE 
Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion被引量：1
《Acta Pharmacologica Sinica》2023年第3期538-545,共8页Yan Chen Chen-yao Wang Gui-ying Zan Song-yu Yao Ying-zhi Deng Xue-lian Shu Wei-wei Wu Yan Ma Yu-jun Wang Chang-xi Yu Jing-gen Liu 
the Ministry of Science and Technology(2021ZD0203500 to YJW;2021ZD0202900 to JGL);the National Natural Science Foundation of China(82030112 to JGL,81773710 to YJW);from Science,Technology Commission of Shanghai Municipality(20ZR1468200 to YJW);from Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019015 to JGL).
Aversive emotion of opioid withdrawal generates motivational state leading to compulsive drug seeking and taking.Kappa opioid receptor(KOR)and its endogenous ligand dynorphin have been shown to participate in the regu...
关键词：morphine withdrawal conditioned place aversion kappa opioid receptor p38 MAPK norBNI dorsal hippocampus 
Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain被引量：6
《Neuroscience Bulletin》2022年第4期403-416,共14页Fu-Jun Zhai Song-Ping Han Tian-Jia Song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng Han 
supported by the National Key Research and Development Program of the Ministry of Science and Technology,China(2016YFC0105501,2019YFD1712000).
Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechani...
关键词：SCS ANALGESIA Opioid receptors METHIONINE-ENKEPHALIN DYNORPHIN ENDORPHINS 
Amygdala dynorphin/κopioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress被引量：1
《Acta Pharmacologica Sinica》2022年第3期577-587,共11页Gui-ying Zan Xiang Sun Yu-jun Wang Rui Liu Chen-yao Wang Wei-jia Du Liu-bin Guo Jing-rui Chai Qing-lin Li Zhi-qiang Liu Jing-gen Liu 
This research was supported by the National Natural Science Foundation of China 81130087,81671322,82030112(to JGL),81771188(to ZQL),81773710(to YJW),81801321(to GYZ);by the Science and Technology Commission of Shanghai Municipality 19401930500(to ZQL);by the Youth Innovation Promotion Association of the Chinese Academy of Sciences 2017334(to YJW);by the China Postdoctoral Science Foundation 2018M640423(to GYZ)。
Major depression disorder is a severe and recurrent neuropsychological disorder characterized by lowered mood and social activity and cognitive impairment.Owing to unclear molecular mechanisms of depression,limited in...
关键词：DEPRESSION social defeat stress AMYGDALA κopioid receptor DYNORPHIN C-FOS ERK norBNI 
Immunohistochemical identification of dynorphin A and Kappa opioid receptor-1 in the digestive system of scallop Chlamys farreri
《Journal of Oceanology and Limnology》2018年第6期2288-2296,共9页SUN Hushan WANG Yiyan LIU Xiaoli LIU Dongwu 
Supported by the Natural Science Foundation of Shandong Province,China(No.ZR2012CM004);the National Natural Science Foundation of China(No.41506190)
Little is known about the roles of dynorphin and Kappa opioid receptor(KOR) in mollusks. In this study, we aim to determine the distribution of dynorphin A and KOR-1 in the digestive system of the scallop Chlamys farr...
关键词：CHLAMYS FARRERI DYNORPHIN DIGESTIVE system kappa OPIOID receptors immunohistochemistry 
Effect of Peptidase Inhibitors on Dynorphin A (1-17) or (1-13)-Induced Antinociception and Toxicity at Spinal Level
《Pharmacology & Pharmacy》2017年第2期33-51,共19页Mitsumasa Matsuda Masanobu Yoshikawa Takugi Kan Mariko Watanabe Junko Ajimi Shigeru Takahashi Masaaki Miura Kenji Ito Hiroyuki Kobayashi Toshiyasu Suzuki 
Our group has earlier demonstrated that three enzymes sensitive to peptidase inhibitors (PIs), amastatin (A)-, captopril (C)-, and phosphoramidon (P), played an important role in inactivation of enkephalins at the spi...
关键词：DYNORPHIN A PEPTIDASE Dynorphin-Converting Enzyme ANTINOCICEPTION ALLODYNIA 
The role of the dynorphin/K opioid receptor system in anxiety被引量：3
《Acta Pharmacologica Sinica》2015年第7期783-790,共8页Ai HANG Yu-jun WANG Ling HE Jing-gen LIU 
Anxiety disorders are the most common and prevalent forms of psychiatric disease, although the biological basis of anxiety is not well understood. The dynorphin/K opioid receptor system is widely distributed in the ce...
关键词：DYNORPHIN K opioid receptor STRESS ANXIETY 
The aconitine analog bulleyaconitine A exhibits anti-hypersensitivity through direct stimulation of dynorphin A release from spinal microglia in the rat model of neuropathy
《中国药理学通报》2015年第B11期74-74,共1页
Aim Aconitine and its structurally-related diterpenoid alkaloids have been shown to interact differential- ly with neuronal voltage-dependent sodium channels and be responsible for their analgesia and toxicity. Bulley...
关键词：bulleyaconitine A (BAA or BLA) ACONITINE ANTI-NOCICEPTION pain HYPERSENSITIVITY morphine toler-ance to ANTI-NOCICEPTION SPINAL cord MICROGLIA DYNORPHIN A. 
Levels of three opioid peptides in goats' CNS induced by different electroacupuncture frequencies
《畜牧与兽医》2012年第S2期49-50,共2页Li-Li Cheng Ming-Xing Ding Cheng Xiong Min-Yan Zhou Zheng-Ying Qiu Qiong Wang 
Acupuncture is a traditional therapeutic technique in Oriental medicine,which has a long history of 4000 years. As a modern version of hand acupuncture,electroacupuncture (EA) can provide a valid analgesic effect and ...
关键词：frequency ELECTROACUPUNCTURE MET-ENKEPHALIN Β-ENDORPHIN dynorphin-A pain threshold GOAT 
A non-opioid pathway for dynorphin-caused spinal cord injury in rats被引量：1
《Neural Regeneration Research》2012年第11期815-820,共6页Yu Chen Liangbi Xiang Jun Liu Dapeng Zhou Hailong Yu Qi Wang Wenfeng Han Mingming Guo 
supported by the Science and Key Technology Research and Development Program of Liaoning Province, No. 2011225021, 2011225041
Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory am...
关键词：spinal cord injury DYNORPHIN kappa opioid receptor antagonist N-methyI-D-aspartate receptor antagonist motor function acid phosphatase 
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