PEPTIDASE

作品数：78被引量：161H指数：6
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USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
《Research》2025年第1期149-163,共15页Liqiu Wang Mengqiu Li Guangyu Lian Shuai Yang Yaoxing Wu Jun Cui 
supported by the National Natural Science Foundation of China(32300730);the Guangdong Science and Technology Department(2023B12120600280);the National Postdoctoral Program for Innovative Talents of China(BX20220365);the China Postdoctoral Science Foundation(2023M734057);the Fundamental Research Funds for the Central Universities(23yxqntd001).
As a key executioner of pyroptosis,Gasdermin D(GSDMD)plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases.So far,the understanding of the mechan...
关键词：USP excessive innate immun host defense innate immune responses ubiquitin specific peptidase selective autophagy 
Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第7期160-162,共3页Yu-Bo Liang Xing-Ming Chen Wan-Ling Luo Yang Ke 
Supported by the National Natural Science Foundation of China,No.82103173 and No.82460461;Medical Subject Leader of Yunnan Province(General Surgery),No.D-2024029;Yunnan Fundamental Research Project for Excellent Young Scholars,No.202401AW070003;the Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province,No.202205AC160063。
This letter comments on the recently published manuscript by Yu et al,in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemn...
关键词：Kinesin family member 9-antisense RNA 1 Hepatocellular carcinoma Ubiquitin-specific peptidase 1 Short stature homeobox 2 CHEMORESISTANCE 
The relationship between the trend of glutamyl transpeptidase changes and the risk of metabolic syndrome:a community cohort study
《China Medical Abstracts(Internal Medicine)》2024年第4期208-209,共2页QU Jianchang 
Objective To evaluate the relationship between the trend of glutamyl transpeptidase(GGT)change and newly developed metabolic syndrome(MS),and to explore the relationship between GGT and MS.Methods The study was a pros...
关键词：PEPTIDASE TREND PROSPECTIVE 
SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway被引量：1
《World Journal of Gastrointestinal Oncology》2024年第5期1890-1907,共18页Xiao-Sheng Jin Lu-Xi Chen Ting-Ting Ji Rong-Zhou Li 
Supported by Ruian Natural Science Foundation,No.MS2021008.
BACKGROUND Serpin peptidase inhibitor clade H member 1(SERPINH1)was initially recognized as an oncogene implicated in various human malignancies.Nevertheless,the clinical relevance and functional implications of SERPI...
关键词：Serpin peptidase inhibitor clade H member 1 Colorectal cancer PROLIFERATION Cell cycle Phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin 
Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
《Asian Journal of Andrology》2024年第2期165-174,共10页Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo 
supported by the Shenzhen Science and Technology Program,China(No.KQTD20190929172749226).
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins.The mitochondrial protease complex(ClpXP),which consists of caseinolyti...
关键词：ClpX homologous chromosome MEIOSIS MITOCHONDRIAL recombination SYNAPSIS 
The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes被引量：1
《Plant Communications》2024年第4期255-274,共20页Fan Xu Huixue Dong Weijun Guo Liang Le Yexing Jing Jennifer C.Fletcher Jiaqiang Sun Li Pu 
supported by the National Natural Science Foundation of China (31872805);the Fundamental Research Funds for Central NonProfit of the Chinese Academy of Agricultural Sciences (CAASZDRW202109 and Y2023PT20);the Nanfan Special Project of the Chinese Academy of Agricultural Sciences (YBXM15).
Plant organ size is an important agronomic trait that makes a significant contribution to plant yield.Despite its central importance,the genetic and molecular mechanisms underlying organ size control remain to be full...
关键词：ULT1 TCP DA1 organ size ENDOREDUPLICATION 
Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8^(+)T cell proportion in tumor-bearing mice through the USP9X signaling pathway
《Chinese Journal of Natural Medicines》2024年第4期329-340,共12页FENG Yutao LI Yuan MA Fen WU Enjiang CHENG Zewei ZHOU Shiling WANG Zhengtao YANG Li SUN Xun ZHANG Jiwei 
supported by Shanghai Pujiang Program(No.20PJ1413000);the National Natural Science Foundation of China(No.82173106,82130115,81290108033,82004004,and 82074011)。
The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective therapeutics.Our research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,mar...
关键词：Notoginsenoside Ft1 Colorectal cancer CD8^(+)T cell Ubiquitin-specific peptidase 9 X-linked β-Catenin Wnt 
miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30被引量：2
《Animal Models and Experimental Medicine》2023年第6期526-536,共11页Yang Jiang Wei Bian Jing Chen Xiaopan Cao ChunYao Dong Ying Xiao Bing Xu XiaoHong Sun 
Liaoning Province Science and Technology Project(grant/award number:2019-BS-221);Shenyang Science and Technology Project(grant/award number:19-112-4-040)。
Background:Alzheimer’sdisease(AD)is a prevalent neurodegenerative disorder causing progressive dementia.Research suggests that microRNAs(miRNAs)could serve as biomarkers and therapeutic targets for AD.Reduced levels ...
关键词：Alzheimer's disease AΒ1-42 miR-137-5p USP30 
Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation被引量：2
《Acta Pharmacologica Sinica》2023年第9期1920-1931,共12页Yu-jia Xu Kun Zeng Ying Ren Chen-yu Mao Ying-hui Ye Xiao-ting Zhu Zi-ying Sun Bi-yin Cao Zu-bin Zhang Guo-qiang Xu Zhen-qian Huang Xin-liang Mao 
supported in part by National Natural Science Foundation of China (#81970194 and#82170176 to XLM);the National Key Research and Development Program of China (#2022YFC2705003 to XLM);Guangzhou Medical University Discipline Construction Funds (Basic Medicine) (Grant No.JCXKJS2022A05 to XLM);Department of Education of Guangdong Province of China (Grant No.2021ZDZX2009 to XLM).
The cell cycle regulator cyclin D3(CCND3)is highly expressed in multiple myeloma(MM)and it promotes MM cell proliferation.After a certain phase of cell cycle,CCND3 is rapidly degraded,which is essential for the strict...
关键词：cyclin D3 multiple myeloma ubiquitin specific peptidase 10 cyclin-dependent kinase mass spectrometry 
Compound heterozygous mutations in tripeptidyl peptidase 1 cause rare autosomal recessive spinocerebellar ataxia type 7:A case report
《World Journal of Clinical Cases》2023年第27期6618-6623,共6页Rui-Han Liu Xin-Yu Wang Yuan-Yuan Jia Xing-Chen Wang Min Xia Qiong Nie Jia Guo Qing-Xia Kong 
Supported by Postdoctoral program of the Affiliated Hospital of Jining Medical University,No.JYFY303573;Health Commission of Shandong Province,No.202006010928;Academician Lin He New Medicine in Jining Medical University,No.JYHL2018FMS05;Affiliated Hospital of Jining Medical University,No.2018-BS-004.
BACKGROUND Spinocerebellar ataxia recessive type 7(SCAR7)is a rare clinical manifestation beginning in childhood or adolescence.SCAR7 is caused by tripeptidyl peptidase 1(TPP1)gene mutations,and presents with cerebell...
关键词：Spinocerebellar ataxia recessive type 7 Tripeptidyl peptidase 1 Compound heterozygous variant Case report 
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