supported by the National Natural Science Foundation of China(22104120);the Three Qin Talents Introduction Program for Youths of Shaanxi Province(2023SYJ26);the Fundamental Research Funds for the Central Universities(xtr052023008);the“Young Talent Support Plan”of Xi’an Jiaotong University to Bailin Zhao;by the National Natural Science Foundation of China(32400427);the China Postdoctoral Science Foundation(2022M712546);the Fundamental Research Funds for the Central Universities(xzy012023018);the Postdoctoral Research Project of Shaanxi Province(2023BSHEDZZ07)to Di Liu;by the Fundamental Research Funds for the Central Universities(xzy022024035)to Chenyang Zhang。
DNA double-strand breaks(DSBs)are the most severe form of DNA damage,primarily repaired by the non-homologous end joining(NHEJ)pathway.A critical step in this process is DNA synapsis,where the two broken ends are brou...
supported by the Shenzhen Science and Technology Program,China(No.KQTD20190929172749226).
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins.The mitochondrial protease complex(ClpXP),which consists of caseinolyti...
supported by grants from the National Key R&D Program of China(2021YFC2700200 and 2022YFC2702602);the National Natural Science Foundation of China(31930034);the Science and Technology Commission of Shanghai Municipality(19JC1415800 to M.-H.T.).
Spermatogenesis is a highly complex developmental process that typically consists of mitosis, meiosis, and spermiogenesis. DNA/RNA helicase DHX36, a unique guanine-quadruplex (G4) resolvase, plays crucial roles in a v...
This work was supported by grants from the National Natural Science Foundation of China(No.31871360,No.32022018,and No.31701176 to JMG)。
The synaptonemal complex(SC)is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes.The SC has a highly conserved ultrastr...
supported by the National Natural Science Foundation of China(31630054,31425018,31821005);Program for Chinese Outstanding Talents in Agricultural Scientific Research。
Meiotic recombination is essential for reciprocal exchange of genetic information between homologous chromosomes and their subsequent proper segregation in sexually reproducing organisms. MLH1 and MLH3 belong to meios...
supported by a grant from the National Science Foundation of USA(No.MCB0718191)
a-kleisins are core components of meiotic and mitotic cohesin complexes. Arabidopsis contains genes encoding four a-kleisins. SYN1, a REC8 ortholog, is essential for meiosis, while SYN2 and SYN4 appear to be SCCI orth...
supported by grants from the National Natural Science Foundation of China(Nos.31360260, 31230038 and U1302261)
Meiosis is the crucial process by which sexually propagating eukaryotes give rise to haploid gametes from diploid cells. Several key processes, like homologous chromosomes pairing, synapsis, recombination, and segrega...
Alzheimer’s disease (AD) is characterized by a decline of cognitive functions. Distinctive histopathological hallmarks are neuritic plaques, neurofibrillary tangles, and synaptic alterations. Abnormally enlarged syna...
During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The me...