The organization,regulation,and biological functions of the synaptonemal complex  

作　　者：Feng-Guo Zhang Rui-Rui Zhang Jin-Min Gao 

机构地区：[1]Institute of Biomedical Sciences,College of Life Sciences,Key Laboratory of Animal Resistance Biology of Shandong Province,Shandong Normal University,Jinan 250014,China

出　　处：《Asian Journal of Andrology》2021年第6期580-589,共10页亚洲男性学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.31871360,No.32022018,and No.31701176 to JMG)。

摘　　要：The synaptonemal complex(SC)is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes.The SC has a highly conserved ultrastructure and plays critical roles in controlling multiple steps in meiotic recombination and crossover formation,ensuring accurate meiotic chromosome segregation.Recent studies in different organisms,facilitated by advances in super-resolution microscopy,have provided insights into the macromolecular structure of the SC,including the internal organization of the meiotic chromosome axis and SC central region,the regulatory pathways that control SC assembly and dynamics,and the biological functions exerted by the SC and its substructures.This review summarizes recent discoveries about how the SC is organized and regulated that help to explain the biological functions associated with this meiosis-specific structure.

关 键 词：chromosome axis chromosome segregation CROSSOVER MEIOSIS meiotic recombination REPRODUCTION SYNAPSIS synaptonemal complex 

分 类 号：Q343.2[生物学—遗传学]