MITOCHONDRIAL

作品数：891被引量：2454H指数：17
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相关领域：医药卫生生物学更多>>
相关作者：戴朴王朝霞侯婷婷管敏鑫唐霄雯更多>>
相关机构：北京大学中国科学院中国人民解放军总医院中国科学院遗传与发育生物学研究所更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Mitochondrial transplantation:a promising strategy for the treatment of retinal degenerative diseases
《Neural Regeneration Research》2025年第12期3370-3387,共18页Jing Chi Bin Fan Yulin Li Qing Jiao Guang-Yu Li 
supported by the National Natural Science Foundation of China,Nos.8247041526,81570864,82171053(to GYL)。
The retina,a crucial neural tissue,is responsible for transforming light signals into visual information,a process that necessitates a significant amount of energy.Mitochondria,the primary powerhouses of the cell,play...
关键词：age-related macular degeneration Leber’s hereditary optic neuropathy mitochondrial transfer mitochondrial transplantation retinal degenerative diseases 
Biological and translational attributes of mitochondrial DNA copy number:Laboratory perspective to clinical relevance
《World Journal of Methodology》2025年第3期38-55,共18页Deepak Parchwani Ragini Singh Digisha Patel 
The mitochondrial DNA copy number(mtDNAcn)plays a vital role in cellular energy metabolism and mitochondrial health.As mitochondria are responsible for adenosine triphosphate production through oxidative phosphorylati...
关键词：Mitochondrial DNA copy number Mitochondrial DNA Quantitative polymerase chain reaction Cancer Neurodegenerative disease AGING 
Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery
《Neural Regeneration Research》2025年第8期2181-2198,共18页Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao 
supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW);the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...
关键词：delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects 
Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria
《Genes & Diseases》2025年第3期533-549,共17页Jingyi Su Yongdong Pan Fengbo Zhong Yi Zhong Jiaxin Huang Shengnan Liu Kaiyuan Wang Kai Lin Xiangchen Gu Dali Li Qihui Wu Hongquan Geng Yuting Guan Guofeng Xu 
supported by grants from the Science and Technology Commission of Shanghai Municipality of China(No.23Y21900102 to G.X.;23ZR1467900 to Q.W.);Shanghai Rising-Star Program(No.22QA1405900 to Y.G.);the National Key R&D Program of China(No.2022YFC2505400,2022YFC3400203 to Y.G.);the National Natural Science Foundation of China(No.82100773 to Y.G.;82101486,82371426 to Q.W.);the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX1621 to Y.G.);the Ningxia Hui Autonomous Region Key Research and Development Project(China)(No.2022BFH02012 to Q.W.).
Cystinuria is the most common inheritable cause of kidney stone disease,with males exhibiting a higher susceptibility than females.However,the cellular origin and underlying mechanisms of sex differences in cystinuria...
关键词：CYSTINURIA Kidney injury MITOCHONDRIA Sex bias Slc3a1 
Mitochondrial quality control in human health and disease
《Military Medical Research》2025年第3期393-458,共66页Bo‑Hao Liu Chen‑Zhen Xu Yi Liu Zi‑Long Lu Ting‑Lv Fu Guo‑Rui Li Yu Deng Guo‑Qing Luo Song Ding Ning Li Qing Geng 
supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...
关键词：Mitochondrial quality control(MQC) METABOLISM Programmed cell death CANCER Cardiovascular disease Metabolic disease Nervous disease Pulmonary disease Kidney disease Digestive system disease 
Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
《Genes & Diseases》2025年第3期180-193,共14页Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 
supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).
Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referre...
关键词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 
Health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency
《Journal of Environmental Sciences》2025年第5期150-160,共11页Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia 
supported by the National Natural Science Foundation of China(Nos.U200420282273603 and 82003427).
Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain ambiguou...
关键词：Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect 
Regulation of lncRNA-ENST on Myc-mediated mitochondrial apoptosis in mesenchymal stem cells:In vitro evidence implicated for acute lung injury therapeutic potential
《World Journal of Stem Cells》2025年第3期65-80,共16页Ye-Zhou Shen Guang-Ping Yang Qi-Min Ma Yu-Song Wang Xin Wang 
Supported by the Peak Supporting Clinical Discipline of Shanghai Health Bureau,No.2023ZDFC0104;the National Key R&D Program of China,No.2019YFA0110601.
BACKGROUND Acute lung injury(ALI)is a fatal and heterogeneous disease.While bone marrow mesenchymal stem cells(BMSCs)have shown promise in ALI repair,their efficacy is compromised by a high apoptotic percentage.Prelim...
关键词：Long noncoding RNA Mesenchymal stem cell MITOCHONDRIAL Apoptosis AUTOPHAGY Acute lung injury 
Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease
《BIOCELL》2025年第3期399-417,共19页Juan Yang Jiahui Zhang Le Zhang Zhenshan Yang 
supported by grants from the Top Medical Expert Team of Wuxi Taihu Talent Plan(Grant Nos.DJTD202106,GDTD202105 and YXTD202101);Medical Key Discipline Program of Wuxi Health Commission(Grant Nos.ZDXK2021007 and CXTD2021005);Top Talent Support Program for Young and MiddleAged People of Wuxi Health Committee(Grant No.BJ2023090);Scientific Research Program of Wuxi Health Commission(Grant Nos.Z20210 and M202208).
With the prevalence of obesity,metabolic dysfunction-associated steatotic liver disease(MASLD)has become the most common chronic liver disease worldwide and can cause a series of serious complications.The pathogenesis...
关键词：Oxidative stress MASLD mitochondrial dysfunction mitochondrial quality control ER-mitochondria association 
Zishen Huoxue decoction(ZSHX)alleviates ischemic myocardial injury(MI)via Sirt5-β-tubulin mediated synergistic mechanism of"mitophagy-unfolded protein response"and mitophagy
《Chinese Journal of Natural Medicines》2025年第3期311-321,共11页Xing Chang Siyuan Zhou Yu Huang Jinfeng Liu Yanli Wang Xuanke Guan Qiaomin Wu Zhiming Liu Ruxiu Liu 
supported by the National Natural Science Foundation of China(No.82305204),the Special Project on Academic Inheritance and Communication,China Academy of Chinese Medical Sciences(No.CI2022E012XB);Chinese Academy of Chinese Medical Sciences Doctoral Talents Training Fund(No.2021);the Special Program for Training Outstanding Young Talents of Chinese Academy of Traditional Chinese Medicine(No.ZZ16-YQ-021);the Innovative Cultivation Project of Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences(No.2022s481).
Zishen Huoxue decoction(ZSHX)enhances cardiomyocyte viability following hypoxic stress;however,its upstream therapeutic targets remain unclear.Network pharmacology and RNA sequencing analyses revealed that ZSHX target...
关键词：MITOPHAGY Mitochondrial unfolded protein response Zishen Huoxue decoction Sirtuin 5 Β-TUBULIN Mitochondrial oxidative stress 
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