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Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
《Genes & Diseases》2025年第3期180-193,共14页Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 
supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).
Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referre...
关键词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 
Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice
《Genes & Diseases》2025年第2期288-303,共16页Qi Li Xiaoyan Qin Liangxu Wang Dingheng Hu Rui Liao Huarong Yu Zhongjun Wu Yanyao Liu 
funded by the National Natural Science Foundation of China (No.82300745 to Yanyao Liu);China Postdoctoral Science Foundation (No.2023M730442 to Yanyao Liu);Chongqing Postdoctoral Science Foundation of China (No.CSTB2023NSCQ-BHX1003 to Yanyao Liu);Postdoctoral Cultivation Project of the First Affiliated Hospital of Chongqing Medical University (No.CYYY-BSHPYXM-202301 to Yanyao Liu);Chongqing Postdoctoral Innovation Talents Support Program (Chongqing,China) (No.2309013437264551 to Yanyao Liu)。
Hepatic ischemia-reperfusion injury is an unavoidable surgical complication of liver transplantation and the leading cause of poor graft function and increased mortality post-transplantation.Multiple mechanisms have b...
关键词：INFLAMMATION Liver ischemia-reperfusion injury Metabolic remodeling Metabolomics TRANSCRIPTOMICS 
Quantifying cell fate change under different stochastic gene activation frameworks
《Quantitative Biology》2025年第1期89-101,共13页Xinxin Chen Ying Sheng Liang Chen Moxun Tang Feng Jiao 
The National Natural Science Foundation of China,Grant/Award Numbers:12271118,12331017。
Gene transcription is a stochastic process characterized by fluctuations in mRNA levels of the same gene in isogenic cell populations.A central question in single-cell studies is how to map transcriptional variability...
关键词：cell fate change mRNA distribution statistical transcription threshold stochastic gene transcription transcription noise 
A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1
《mLife》2025年第1期96-100,共5页Yujie Zhang Wenjun Wu Ke Huang Fang-Jie Zhao 
supported by the Natural Science Foundation of China(Grant Nos.42077210 and 41930758 to Ke Huang and Fang-jie Zhao,respectively).
Impact statement Arsenic is the most common toxic metalloid in the environment.Nearly all organisms have genes for arsenic detoxification.Arsenic detoxification genes are frequently organized in chromosomal or plasmid...
关键词：ars operon Ars responsive toxic metalloid evolution relationship ArsR transcriptional repressor arsenic resistance arsr repressor 
MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava
《The Crop Journal》2025年第1期204-214,共11页Mengtao Li Xiao Zhao Yajun Li Yuanchao Li Xiaoye Zhao Weitao Mai Luqman Khan Qibing Liang Qingchun Yin Wenquan Wang Jinping Liu Xin Chen 
supported by grants from the National Natural Science Foundation of China(32460505);China Agriculture Research System(CARS-11);the Chinese Academy of Tropical Agricultural Sciences for the Science and Technology Innovation Team of the National Tropical Agricultural Science Center(CATASCXTD202301);Additional support was provided by the Hainan Province Graduate Innovation Research Project(Hyb2020-09);the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation(KF-2023016).
The high content of cyanogenic glycosides(CG)in cassava tubers affects food safety.CG are involved in the plant growth and development and protect cassava leaves from herbivorous predators.However,the regulatory mecha...
关键词：Cyanogenic glycosides Cytochrome P450 Manihot esculenta MePHD1.2 
Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica
《Journal of Oceanology and Limnology》2025年第1期187-195,共9页Lixian LIU Li GUO Hang LIU Xiaohui PAN Yanan ZONG Leili FENG Guanpin YANG 
Supported by the National Key R&D Program of China(No.2022YFF1102300);the Key R&D Program of Shandong Province,China(No.2022LZGC004);the National Natural Science Foundation of China(No.32102757);the Science&Technology Innovation Project of Laoshan Laboratory(No.LSKJ202203205);the Fundamental Research Funds for the Central Universities(No.202262001)。
Abnormal content of protein SEIPIN causes Berardinelli-Seip congenital lipodystrophy type 2(BSCL2)in humans.Previous studies have shown that Arabidopsis thaliana has evolved three SEIPIN homologs,determining the fusio...
关键词：Nannochloropsis oceanica antisense RNA SEIPIN neutral lipid 
GEPREP:A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses
《Journal of Sport and Health Science》2025年第1期142-154,共13页Lei Sun Jinwen Luan Jinbiao Wang Xiaoli Li Wenqian Zhang Xiaohui Ji Longhua Liu Ru Wang Bingxiang Xu 
supported by grants from the Shanghai“Science and Technology Innovation Action Plan”Social Development Science and Technology Reach Project(22dz1204600);Shanghai Sports Science and Technology Program(24C002);the National Key R&D Program of China(2020YFA0803800);the National Natural Science Foundation of China(32200515,32271226);Shanghai Municipal Science and Technology Committee of Shanghai outstanding academic leaders plan(21XD1403200).
Background Physical activity can regulate and affect gene expression in multiple tissues and cells.Recently,with the development of next-generation sequencing,a large number of RNA-sequencing(RNA-seq)-based gene expre...
关键词：Database Sports intervention Transcription quantification 
Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA
《Genes & Diseases》2025年第1期238-249,共12页Jihua Ren Shengtao Cheng Fang Ren Huiying Gu Daiqing Wu Xinyan Yao Ming Tan Ailong Huang Juan Chen 
supported by funds from the National Key R&D Program of China(No.2022YFA1303600);the National Natural Science Foundation of China(No.82273423,82202501);Scientific and Technological Research Program of Chongqing Municipal Education Commission of China(No.KJQN202100429);Natural Science Foundation Project of Chongqing,China(No.CSTB2022NSCQ-MSX0864);College Young Teachers Fund of the Fok Ying Tung Education Foundation(China)(No.171100).
Human hepatitis B virus(HBV)infection is the major cause of acute and chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.Although the application of prophylactic vaccination programs has successfully pre...
关键词：CCCDNA Epigenetic regulation HBV HBX TRANSCRIPTION 
Transcription coactivator YAP1 promotes CCND1/CDK6 expression,stimulating cell proliferation in cloned cattle placentas
《Zoological Research》2025年第1期122-138,共17页Shan-Shan Wu Xiao-Yu Zhao Lei Yang Chao Hai Di Wu Xue-Fei Liu Li-Shuang Song Chun-Ling Bai Guang-Hua Su Guang-Peng Li 
supported by the National Natural Science Foundation of China (32060755);Natural Science Foundation of Inner Mongolia (2024MS03001);Inner Mongolia Autonomous Region Open Competition Projects (2022JBGS0018);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (NJYT23090);Inner Mongolia Autonomous Region Science and Technology Leading Team (2022LJRC0006);Inner Mongolia Autonomous Region Science and Technology Major Project (2021ZD0009);Major Agricultural Science and Technology Project of the Ministry of Agriculture and Rural Affairs (NK2022130203);Central Government Guides Local Science and Technology Development Funds (2022ZY0212);Inner Mongolia Autonomous Region High-level Talent Support Program;Inner Mongolia University Chief Scientist Program。
Somatic cell nuclear transfer(SCNT)has been successfully employed across various mammalian species,yet cloned animals consistently exhibit low pregnancy rates,primarily due to placental abnormalities such as hyperplas...
关键词：Somatic cell nuclear transfer Cloned cattle Placental hypertrophy Cell proliferation CCND1-CDK6 YAP1 
Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma被引量：1
《World Journal of Hepatology》2024年第12期1480-1492,共13页Jun-Ling Yang Jie Yang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao 
Supported by the National Natural Science Foundation of China,No.32470985 and No.81673241.
BACKGROUND Angiopoietin-2(Ang-2)level is related to hepatocellular carcinoma(HCC)pro-gression.However,the dynamic expression and regulatory mechanism of Ang-2 remain unclear.AIM To investigate Ang-2 levels in chronic ...
关键词：ANGIOPOIETIN-2 Hypoxia-inducible factor-1α HEPATOCARCINOGENESIS Dynamic model Metastasis 
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