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Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice
《Genes & Diseases》2025年第2期288-303,共16页Qi Li Xiaoyan Qin Liangxu Wang Dingheng Hu Rui Liao Huarong Yu Zhongjun Wu Yanyao Liu 
funded by the National Natural Science Foundation of China (No.82300745 to Yanyao Liu);China Postdoctoral Science Foundation (No.2023M730442 to Yanyao Liu);Chongqing Postdoctoral Science Foundation of China (No.CSTB2023NSCQ-BHX1003 to Yanyao Liu);Postdoctoral Cultivation Project of the First Affiliated Hospital of Chongqing Medical University (No.CYYY-BSHPYXM-202301 to Yanyao Liu);Chongqing Postdoctoral Innovation Talents Support Program (Chongqing,China) (No.2309013437264551 to Yanyao Liu)。
Hepatic ischemia-reperfusion injury is an unavoidable surgical complication of liver transplantation and the leading cause of poor graft function and increased mortality post-transplantation.Multiple mechanisms have b...
关键词：INFLAMMATION Liver ischemia-reperfusion injury Metabolic remodeling Metabolomics TRANSCRIPTOMICS 
MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava
《The Crop Journal》2025年第1期204-214,共11页Mengtao Li Xiao Zhao Yajun Li Yuanchao Li Xiaoye Zhao Weitao Mai Luqman Khan Qibing Liang Qingchun Yin Wenquan Wang Jinping Liu Xin Chen 
supported by grants from the National Natural Science Foundation of China(32460505);China Agriculture Research System(CARS-11);the Chinese Academy of Tropical Agricultural Sciences for the Science and Technology Innovation Team of the National Tropical Agricultural Science Center(CATASCXTD202301);Additional support was provided by the Hainan Province Graduate Innovation Research Project(Hyb2020-09);the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation(KF-2023016).
The high content of cyanogenic glycosides(CG)in cassava tubers affects food safety.CG are involved in the plant growth and development and protect cassava leaves from herbivorous predators.However,the regulatory mecha...
关键词：Cyanogenic glycosides Cytochrome P450 Manihot esculenta MePHD1.2 
Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica
《Journal of Oceanology and Limnology》2025年第1期187-195,共9页Lixian LIU Li GUO Hang LIU Xiaohui PAN Yanan ZONG Leili FENG Guanpin YANG 
Supported by the National Key R&D Program of China(No.2022YFF1102300);the Key R&D Program of Shandong Province,China(No.2022LZGC004);the National Natural Science Foundation of China(No.32102757);the Science&Technology Innovation Project of Laoshan Laboratory(No.LSKJ202203205);the Fundamental Research Funds for the Central Universities(No.202262001)。
Abnormal content of protein SEIPIN causes Berardinelli-Seip congenital lipodystrophy type 2(BSCL2)in humans.Previous studies have shown that Arabidopsis thaliana has evolved three SEIPIN homologs,determining the fusio...
关键词：Nannochloropsis oceanica antisense RNA SEIPIN neutral lipid 
Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA
《Genes & Diseases》2025年第1期238-249,共12页Jihua Ren Shengtao Cheng Fang Ren Huiying Gu Daiqing Wu Xinyan Yao Ming Tan Ailong Huang Juan Chen 
supported by funds from the National Key R&D Program of China(No.2022YFA1303600);the National Natural Science Foundation of China(No.82273423,82202501);Scientific and Technological Research Program of Chongqing Municipal Education Commission of China(No.KJQN202100429);Natural Science Foundation Project of Chongqing,China(No.CSTB2022NSCQ-MSX0864);College Young Teachers Fund of the Fok Ying Tung Education Foundation(China)(No.171100).
Human hepatitis B virus(HBV)infection is the major cause of acute and chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.Although the application of prophylactic vaccination programs has successfully pre...
关键词：CCCDNA Epigenetic regulation HBV HBX TRANSCRIPTION 
Transcription coactivator YAP1 promotes CCND1/CDK6 expression,stimulating cell proliferation in cloned cattle placentas
《Zoological Research》2025年第1期122-138,共17页Shan-Shan Wu Xiao-Yu Zhao Lei Yang Chao Hai Di Wu Xue-Fei Liu Li-Shuang Song Chun-Ling Bai Guang-Hua Su Guang-Peng Li 
supported by the National Natural Science Foundation of China (32060755);Natural Science Foundation of Inner Mongolia (2024MS03001);Inner Mongolia Autonomous Region Open Competition Projects (2022JBGS0018);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (NJYT23090);Inner Mongolia Autonomous Region Science and Technology Leading Team (2022LJRC0006);Inner Mongolia Autonomous Region Science and Technology Major Project (2021ZD0009);Major Agricultural Science and Technology Project of the Ministry of Agriculture and Rural Affairs (NK2022130203);Central Government Guides Local Science and Technology Development Funds (2022ZY0212);Inner Mongolia Autonomous Region High-level Talent Support Program;Inner Mongolia University Chief Scientist Program。
Somatic cell nuclear transfer(SCNT)has been successfully employed across various mammalian species,yet cloned animals consistently exhibit low pregnancy rates,primarily due to placental abnormalities such as hyperplas...
关键词：Somatic cell nuclear transfer Cloned cattle Placental hypertrophy Cell proliferation CCND1-CDK6 YAP1 
Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma被引量：1
《World Journal of Hepatology》2024年第12期1480-1492,共13页Jun-Ling Yang Jie Yang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao 
Supported by the National Natural Science Foundation of China,No.32470985 and No.81673241.
BACKGROUND Angiopoietin-2(Ang-2)level is related to hepatocellular carcinoma(HCC)pro-gression.However,the dynamic expression and regulatory mechanism of Ang-2 remain unclear.AIM To investigate Ang-2 levels in chronic ...
关键词：ANGIOPOIETIN-2 Hypoxia-inducible factor-1α HEPATOCARCINOGENESIS Dynamic model Metastasis 
Physiological and molecular bases of the nickel toxicity responses in tomato
《Stress Biology》2024年第1期448-464,共17页Hao Yu Weimin Li Xiaoxiao Liu Qianqian Song Junjun Li Jin Xu 
supported by the China National Natural Sciences Foundation(32070314)to J.X.
Nickel(Ni),a component of urease,is a micronutrient essential for plant growth and development,but excess Ni is toxic to plants.Tomato(Solanum lycopersicum L.)is one of the important vegetables worldwide.Excessive use...
关键词：Nickel toxicity MICRONUTRIENTS Oxidative stress response PHYTOHORMONES Transcription regulatory network 
Shuangshen Granules Suppress Myeloid-derived Suppressor Cell-mediated Lung Premetastatic Niche Development by Targeting Sphingosine-1-Phosphate Receptor-1/Signal Transducer,Activator of Transcription 3 Signaling
《World Journal of Traditional Chinese Medicine》2024年第4期485-494,共10页Rui Liu Jia-Qi Hu Xing Zhang Xiao-Yi Wu Hua-Min Wei Yuan-Chen Zhao Shu-Lin He Jing Yu Xin Qi Ying-Xia Pei Hong Chen Wei-Dong Li Bao-Jin Hua 
supported by the Special Training of Scientific and Technological Talents,China Academy of Chinese Medical Sciences (grant number ZZ13-YQ-023,ZZ13-YQ-028);the National Natural Science Foundation of China(grant number 82174465,82074338,82274609,82104961,82174463);the Beijing Municipal Science and Technology Commission (grant number Z181100001618006);Scientificand Technological Innovation Project of China Academy of Chinese Medical Sciences (grant number CI2021A01810,CI2021A01814,CI2021A01808,CI2021B009);Traditional Chinese Medicine Innovation Team Project of the National Administration of Traditional Chinese Medicine(grant number ZYYCXTD-C-202205);Central High-Level Traditional Chinese Medicine Hospital Clinical Research and Achievement Transformation Capacity Enhancement Project-Special Project Inheriting the Academic Experienceof Renowned Traditional Chinese Medicine Experts(HLCMHPP2023012);China Academy of Chinese Medical Sciences Special Project for Research and Development of Superior Diseases,Hospital Preparations,New Drugs(ZZ15-XY-PT-01);Xu Hang Project for Cultivating Young Top Talents at Guang'anmen Hospital (CZ40908);The Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ17XRZ-023);Clinical Research Expenses of the Central High-level Hospital of Traditional Chinese Medicine (HLCMHPP2023101)
Background:Shuangshen granule s(SSGs) are extensively utilized for the treatment of lung cancer in China and have been reported to possess tumor-protective and anti-metastatic effects.Therefore,it is crucial to unders...
关键词：Lung metastasis myeloid‑derived suppressor cell premetastatic niche Shuangshen granules sphingosine‑1‑phosphate receptor‑1/signal transducer activator of transcription 3 axis 
Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer
《Oncology Research》2024年第12期1881-1890,共10页YUAN YIN ZHENGYIN WANG YUJIE HU JIA WANG YI WANG QUN LU 
Background:Caffeic acid(CA)is considered a promising phytochemical that has inhibited numerous cancer cell proliferation.Therefore,it is gaining increasing attention due to its safe and pharmacological applications.In...
关键词：Caffeic acid(CA) Signal transducer and activating transcription-3(STAT-3) Prostate cancer PROLIFERATION Apoptosis 
TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4
《Neuroscience Bulletin》2024年第12期1937-1942,共6页Meijie Ding Dingfeng Li Juan Zhang Qiang Liu 
supported by the National Key R&D Program of China(2021YFA0804900 and 2020YFA0509300);the National Natural Science Foundation of China(82125009,82330045,82071185,32100794,92149303,and 32121002);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000);a CAS Project for Young Scientists in Basic Research(YSBR-013);Plans for Major Provincial Science&Technology Projects(202303a07020004);the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003);Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003);USTC Research Funds of the Double First-Class Initiative.
Dear Editor,Learning-induced expression of activity-dependent genes,especially immediate-early genes(IEGs),is required for the conversion of experience-induced neuronal activity into long-term memory[1].Neuronal Per-A...
关键词：IMMEDIATE FOS TAF 
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