ISCHEMIA/REPERFUSION

作品数：164被引量：1229H指数：18
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相关机构：华中科技大学广东省心血管病研究所台湾大学中国药科大学更多>>
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Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
《Genes & Diseases》2025年第3期180-193,共14页Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 
supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).
Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referre...
关键词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 
Interferon-αstimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
《Military Medical Research》2025年第2期184-203,共20页Kai-Wei Jia Ren-Qi Yao Yi-Wen Fan Ding-Ji Zhang Ye Zhou Min-Jun Wang Li-Yuan Zhang Yue Dong Zhi-Xuan Li Su-Yuan Wang Mu Wang Yun-Hui Li Lu-Xin Zhang Ting Lei Liang-Chen Gui Shan Lu Ying-Yun Yang Si-Xian Wang Yi-Zhi Yu Yong-Ming Yao Jin Hou 
National Key Research and Development Program of China(2023YFC2505900);National Natural Science Foundation of China(92269204,82171755,92369106,82171749,82171811,82073184);Military Outstanding Youth Program(2020QN06119,01-SWK JYCJJ07,23SWAQ53);Program of Leading Talents in Shanghai,and Shanghai Shuguang Program(20SG39)。
Background Liver ischemia/reperfusion(I/R)injury is usually caused by hepatic inflow occlusion during liver surgery,and is frequently observed during war wounds and trauma.Hepatocyte ferroptosis plays a critical role ...
关键词：Ischemia/reperfusion(I/R) DExH-box helicase 58(DHX58) Glutathione peroxidase 4(GPX4) m6A modification YT521-B homology domain containing 2(YTHDC2) 
20-Hydroxyecdysone Partially Alleviates Ischemia/Reperfusion-Induced Damage of Mouse Hind Limb Skeletal Muscle
《BIOCELL》2025年第3期437-450,共14页Alena A.Semenova Anastasia D.Igoshkina Alena A.Cherepanova Natalia V.Mikina Anastasia E.Stepanova Olga E.Krasnoshchekova Vyacheslav A.Sharapov Rimma G.Savchenko Lyudmila V.Parfenova Mikhail V.Dubinin 
supported by a grant from the Russian Science Foundation(23-75-01061)。
Objectives:Skeletal muscle ischemia/reperfusion injury(IRI)occurs as a result of a marked reduction in arterial perfusion to a limb and can lead to tissue death and threaten limb viability.This work assessed the effec...
关键词：Skeletal muscle ISCHEMIA/REPERFUSION 20-HYDROXYECDYSONE MITOCHONDRIA oxidative stress 
ANP Increases Zn^(2+)Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts
《Current Medical Science》2025年第1期35-50,共16页Yu-ting Ma Tong Laga Chong-ning Zhong Bing-qi Zhuang Hai-lian Quan Lan Hong 
supported by the National Natural Science Foundation of China(NSFC)(No.82360065 and No.81760047).
Objective Atrial natriuretic peptide(ANP)and Zn^(2+)have been shown to confer cardioprotection against ischemia/reperfu-sion(I/R)injury.Zn^(2+)alleviates myocardial hypertrophy and pulmonary hypertension by regulating...
关键词：Atrial natriuretic peptide ISCHEMIA/REPERFUSION Zn^(2+) Zn^(2+)transporter Zn2⁺transporter 8 Hypoxia-inducible factor 1-alpha PI3K 
Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views
《Engineering》2024年第7期77-99,共23页Jingyan Han Quan Li Kai Sun Chunshui Pan Jian Liu Ping Huang Juan Feng Yanchen Liu Gerald A.Meininger 
supported by the National Natural Science Foundation of China(81873217 and 82074310);the State Key Laboratory of Core Technology in Innovative Chinese Medicine(20221108).
Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell i...
关键词：ISCHEMIA/REPERFUSION LIPOPOLYSACCHARIDE Natural products Leukocyte activation Hyperpermeability 
Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system被引量：3
《Animal Models and Experimental Medicine》2024年第1期48-55,共8页Ying Wu Caijiao Hu Zhihui Li Feiyang Li Jianyi Lv Meng Guo Xin Liu Changlong Li Xueyun Huo Zhenwen Chen Lifeng Yang Xiaoyan Du 
National Key Research and Development Program of China,Grant/Award Number:2021YFF0702402;National Natural Science Foundation of China,Grant/Award Number:32070531。
Background:The Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of Willis.However,the low incidence and unpredictability of symp...
关键词：ISCHEMIA/REPERFUSION Mongolian gerbil standardized model system unilateral carotid occlusion 
Acyl-CoA synthase ACSL4:an essential target in ferroptosis and fatty acid metabolism被引量：15
《Chinese Medical Journal》2023年第21期2521-2537,共17页Kaiyue Ding Chongbin Liu Li Li Ming Yang Na Jiang Shilu Luo Lin Sun 
supported by the Key Program of General Program of the National Natural Science Foundation of China(NSFC)(No.81730018);Natural Science Foundation of Hunan Province(No.2021JC0003)
Long-chain acyl-coenzyme A(CoA)synthase 4(ACSL4)is an enzyme that esterifies CoA into specific polyunsaturated fatty acids,such as arachidonic acid and adrenic acid.Based on accumulated evidence,the ACSL4-catalyzed bi...
关键词：Long-chain acyl-coenzyme A(CoA)synthase 4(ACSL4) Ferroptosis Fatty acid metabolism Cancer ISCHEMIA/REPERFUSION Metabolic diseases 
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy被引量：2
《Chinese Journal of Natural Medicines》2023年第9期682-693,共12页LIU Huiling HUANG Zhou JIANG Hong SU Ke SI Zilin WU Wenhui WANG Hanyu LI Dongxue TAN Ninghua ZHANG Zhihao 
the National Natural Science Foundation of China(No.81700559);the Natural Science Foundation of Hubei Province(No.2021CFB360);the Program for Jiangsu Province Innovative Research Team.
Acute kidney injury(AKI)is an important factor for the occurrence and development of CKD.The protective effect of dihydroartemisinin on AKI and and reported mechanism have not been reported.In this study,we used two a...
关键词：AKI DIHYDROARTEMISININ Renal tubular senescence Fibrosis AUTOPHAGY 
Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy
《Chronic Diseases and Translational Medicine》2023年第3期238-249,共12页Mengjiao Yang Zhihui Wang Jin Xie MdReyad‐ul‐Ferdous Siying Li Yongfeng Song 
Independently cultivates innovation team program of Jinan,China,Grant/Award Number:2021GXRC048;Shandong Provincial Natural Science Foundation,Grant/Award Number:ZR2020ZD14;National Natural Science Foundation of China,Grant/Award Number:82270922;National Key Research and Development Program of China,Grant/Award Number:2022YFA0806100。
Background:Liver ischemia/reperfusion(I/R)injury is a complex and multifactorial pathophysiological process.It is well recognized that the membrane permeability transition pore(mPTP)opening of mitochondria plays a cru...
关键词：APOPTOSIS AUTOPHAGY cyclophilin D ISCHEMIA/REPERFUSION NECROSIS reactive oxygen species 
The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion被引量：2
《The Journal of Biomedical Research》2023年第4期230-254,共25页Natalia V.Naryzhnaya Leonid N.Maslov Ivan A.Derkachev Huijie Ma Yi Zhang NRajendra Prasad Nirmal Singh Feng Fu Jianming Pei Akpay Sarybaev Akylbek Sydykov 
supported by the Russian Science Foundation grant 22-15-00048;The section dedicated to the role of kinases in the cardioprotective effect of CH is framed within the framework of state assignments 122020300042-4.
The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new app...
关键词：HEART VESSELS infarct size ARRHYTHMIAS chronic hypoxia 
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