Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views  

作　　者：Jingyan Han Quan Li Kai Sun Chunshui Pan Jian Liu Ping Huang Juan Feng Yanchen Liu Gerald A.Meininger 

机构地区：[1]Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing 100191,China [2]Tasly Microcirculation Research Center,Peking University Health Science Center,Beijing 100191,China [3]Key Laboratory of Stasis and Phlegm,State Administration of Traditional Chinese Medicine of the People’s Republic of China,Beijing 100191,China [4]Beijing Laboratory of Integrative Microangiopathy,Peking University Health Science Center,Beijing 100191,China [5]Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology,University of Missouri,Columbia,MO 65211,USA

出　　处：《Engineering》2024年第7期77-99,共23页工程（英文）

基　　金：supported by the National Natural Science Foundation of China(81873217 and 82074310);the State Key Laboratory of Core Technology in Innovative Chinese Medicine(20221108).

摘　　要：Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and thrombosis.These disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and platelets.In clinical practice,aside from drugs that target abnormal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory disturbances.Natural products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfusion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory disturbances.In recent years,numerous research papers on the improvement of microcirculatory function by natural products have been published in international journals.In 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology&Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural components of compounded Chinese medicine,respectively.This review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPSinduced microcirculatory disturbances and tissue injury.Based on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

关 键 词：ISCHEMIA/REPERFUSION LIPOPOLYSACCHARIDE Natural products Leukocyte activation Hyperpermeability 

分 类 号：R96[医药卫生—药理学]