Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion  

作　　者：Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 

机构地区：[1]School of Basic Medical Sciences,Hebei University,Baoding,Hebei 071002,China [2]Basic Medical Department,Graduate School,Chinese PLA General Hospital,Beijing 100853,China [3]Institute for Translational Medicine,The Affiliated Hospital of Qingdao University,College of Medicine,Qingdao University,Qingdao,Shandong 266000,China [4]The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121000,China

出　　处：《Genes & Diseases》2025年第3期180-193,共14页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).

摘　　要：Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referred to as mitochondrial DNA(mtDNA).mtDNA encodes necessary electron transport chain complex subunits,as well as the essential RNAs for their translation within the organelle.Therefore,the precondition for intact mitochondrial function and cardiomyocyte survival is the integrity of mtDNA.Accumulating evidence suggests that the disruption of mtDNA integrity is involved in ischemia/reperfusion-induced mitochondrial dysfunction and cardiomyocyte injury.Here,we review the current opinions about the pathways of mtDNA integrity maintenance and discuss the role of mtDNA integrity in cardiomyocyte injury reacting to ischemia/reperfusion.We also discuss the mechanisms by which mtDNA mediates ischemia/reperfusion-induced cardiomyocyte injury,together with therapeutic strategies by targeting mtDNA.

关 键 词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 

分 类 号：R54[医药卫生—心血管疾病]