REPLICATION

作品数：445被引量：819H指数：14
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Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
《Genes & Diseases》2025年第3期180-193,共14页Shengnan Hu Xueying Tang Fangrui Zhu Chen Liang Sa Wang Hongjie Wang Peifeng Li Yuzhen Li 
supported by grants from the National Natural Science Foundation of China(No.81970246,81470437).
Mitochondria serve as the energy provider and enable life activities,and they are the only organelles containing extra-chromosomal DNA.Each mitochondrion contains multiple copies of its genome,which is usually referre...
关键词：CARDIOMYOCYTE ISCHEMIA/REPERFUSION mtDNA Package Repair REPLICATION TRANSCRIPTION 
BEND6 promotes RNA viruses'replication by inhibiting innate immune responses
《Science China(Life Sciences)》2025年第4期1073-1083,共11页Tong Chen Ling Ding Shaoyu Tu Huimin Sun Jiahui Zou Aotian Ouyang Meijun Jiang Yi Feng Meilin Jin Huanchun Chen Hongbo Zhou 
supported by the National Key Research and Development Program of China(2021YFD1800204);the National Natural Science Foundation of China(32025036);the Fundamental Research Funds for the Central Universities(2662023PY005);Hubei Hongshan Laboratory(2022hszd005);the earmarked fund for CARS-41;the Natural Science Foundation of Hubei Province(2021CFA016)。
Innate immunity serves as a crucial defense mechanism against invading pathogens,yet its negative regulatory network remains under explored.In this study,we identify BEN domain-containing protein 6(BEND6)as a novel ne...
关键词：innate immunity BEND6 RNAvirus IRF3 IFN-Β 
Genome-wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus
《mLife》2025年第1期55-69,共15页Guangwen Wang Li Jiang Jinliang Wang Qibing Li Jie Zhang Fandi Kong Ya Yan Yuqin Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Liling Liu Zhigao Bu Hualan Chen Chengjun Li 
supported by the National Key Research and DevelopmentProgram of China(2021YFD1800203 and 2021YFD1800204);the National Natural Science Foundation of China(NSFC)(32192453,32272979,and 32172847);the China PostdoctoralScience Foundation(2019M660897);the Innovation Program ofChinese Academy of Agricultural Sciences(CAAS-CSLPDCP-202401);the Earmarked Fund for China Agriculture Re-search System(CARS-41-G12)。
The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health.In thisstudy,we conducted a genome-wide siRNA library screening against the highly pathogenic H5N1 i...
关键词：genome-wide siRNA library screening GO analysis H5N1 influenza virus host cellular factor reactome pathwayanalysis 
Favipiravir-RTP as a Potential Therapeutic Agent for Inhibiting Dengue Virus Replication
《Journal of Biosciences and Medicines》2025年第2期268-286,共19页Pui-Jen Tsai 
Currently, no clinically approved therapeutic drugs specifically target dengue virus infections. This study aims to evaluate the potential of antiviral drugs originally developed for other purposes as viable candidate...
关键词：DENGUE Antiviral Drugs Favipiravir AlphaFold 3 Molecular Docking 
CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB
《Virologica Sinica》2025年第1期92-108,共17页Li Yang Xiao-Tao Zeng Rong-Hua Luo Ying Tang Si-Xue Ren Xin-Yan Long Xiang-Hui Fu Wan-Jiang Zhang Hai-Yan Ren Yong-Tang Zheng Wei Cheng 
supported by grants from the National Natural Science Foundation of China(32071236);the National Science Fund for Distinguished Young Scholars(32225001);the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYGD23018);Key Science and Technology Research Projects in Key Areas of the Corps(2023AB053);the National Key Research and Development Program of China(2022YFC2303700);the Joint Project of Pengzhou People's Hospital with Southwest Medical University(2024PZXNYD02);Project funded by China Postdoctoral Science Foundation(2020M683304);Sichuan Science and Technology Support Project(2021YJ0502);Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH082).
Virus-encoding RNA-dependent RNA polymerase(RdRp)is essential for genome replication and gene transcription of human coronaviruses(HCoVs),including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).We previo...
关键词：Human coronaviruses(HCoVs) RNA-Dependent RNA polymerase (RdRp) CREB-regulated transcription coactivator 3(CRTC3) Virus replication Virus-host interaction Cyclic AMP response element-binding protein(CREB) 
A Collaborative Broadcast Content Recording System Using Distributed Personal Video Recorders
《Computers, Materials & Continua》2025年第2期2555-2581,共27页Eunsam Kim Choonhwa Lee 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Nos.2019R1A2C1002221 and RS-2023-00252186);Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(Nos.2021-0-00590,RS-2021-II210590;Decentralized High Performance Consensus for Large-Scale Blockchains).
Personal video recorders (PVRs) have altered the way users consume television (TV) content by allowing users to record programs and watch them at their convenience, overcoming the constraints of live broadcasting. How...
关键词：Collaborative recording TV content personal video recorder erasure coding REPLICATION 
The evolutionarily diverged single-stranded DNA-binding proteins SSB1/SSB2 differentially affect the replication,recombination and mutation of organellar genomes in Arabidopsis thaliana
《Plant Diversity》2025年第1期127-135,共9页Weidong Zhu Jie Qian Yingke Hou Luke R.Tembrock Liyun Nie Yi-Feng Hsu Yong Xiang Yi Zou Zhiqiang Wu 
supported by grants from the National Natural Science Foundation of China(32170238,32400191);Guangdong Basic and Applied Basic Research Foundation(2023A1515111029);the Science,Technology and Innovation Commission of Shenzhen Municipality(RCYX20200714114538196);the Chinese Academy of Agricultural Sciences Elite Youth Program(grant 110243160001007);the Guangdong Pearl River Talent Program(2021QN02N792)。
Single-stranded DNA-binding proteins(SSBs)play essential roles in the replication,recombination and repair processes of organellar DNA molecules.In Arabidopsis thaliana,SSBs are encoded by a small family of two genes(...
关键词：SSB Organellar genomes REPLICATION Recombination MUTATION 
Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction
《Science China(Physics,Mechanics & Astronomy)》2025年第1期177-187,共11页Senkuan Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina Hu Weihua Wang 
supported by the Key Basic and Applied Research Program of Guangdong Province(Grant No.2019B030302010);the Taishan Scholars Program of Shandong Province(Grant No.tsqn201909010);the National Natural Science Foundation of China(Grant Nos.51901139,51971120 and U1902221);the Key R&D Program of Shandong Province(Grant No.2022CXGC020308)。
As a microforming technique,micro/nano-structural replication possesses advantages of high precision and efficiency.With the remarkable superplasticity in the supercooled liquid region,amorphous alloys or metallic gla...
关键词：metallic glass amorphous alloy MICROFORMING IMPRINTING machine learning 
C-myc modulates the replication of RGNNV via glutamine-mediated ATP production in grouper fin cells
《Aquaculture and Fisheries》2024年第6期929-936,共8页Minshan Yao Hong Chen Junjie Tao Lixiang Wei Ying Tang Junyan Lin Fei Shi Fanbin Zhan Yanan Li Jun Li Zhendong Qin Li Lin 
jointly supported by the National Natural Science Foundation of China(31872606,31902409,31572657,U1701233).
C-myc is a proto-oncogene that plays an important role in a variety of diseases.There were a lot of research on the correlation between C-myc and human viruses.However,the study about C-myc related to aquatic species ...
关键词：Red grouper nervous necrosis virus(RGNNV) C-MYC GLUTAMINE ATP 
Defect-insensitive cylindrical surface lattice resonance array and its batch replication for enhanced immunoassay
《Microsystems & Nanoengineering》2024年第6期151-160,共10页Bin Zhou Chao Hu Haoyang Li Xiangyi Ye Baohua Wen Zhangkai Zhou Jingxuan Cai Jianhua Zhou 
support from the National Key Research and Development Plan(2021YFA1400804);the National Natural Science Foundation of China(Nos.22174167,21775168,62205382);Guangdong Basic and Applied Basic Research Foundation(Nos.2021A1515110388,2024A1515011707);the Foundation of Sun Yat-sen University(No.76190-18841213);Key Basic Research Project of Shenzhen Natural Science Foundation(No.JCYJ20220818102014028);the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument(No.2020B1212060077).
Surface lattice resonances(SLR)have been demonstrated to enhance the sensitivity and reduce the full width at half maximum(FWHM)of the plasmonic resonances.However,their widespread application in immunoassays has been...
关键词：CYLINDRICAL insensitive RESONANCE 
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