云南高校图书馆联盟文献共享服务平台- HBX

HBX: 作品数：388被引量：845H指数：13; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：冯涛黄佳祎林忠宁林育纯林松挺更多>>; 相关机构：重庆医科大学华中科技大学中南大学第二军医大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金陕西省自然科学基金更多>>

HBx调节lncRNA在HCC发生、发展中的研究进展: 《现代免疫学》2025年第1期82-88,共7页田旭云刘琳曾怡罗昊翔; 广西自然科学技术基金项目(2018GXNSFAA138030);百色市科学研究与技术开发计划项目(百科20224133);右江民族医学院研究生创新计划项目(YXCXJH2023002)。; 原发性肝细胞癌(hepatocellular carcinoma,HCC)是目前常见的恶性肿瘤之一,引发HCC的主要危险因素是HBV感染。乙型肝炎病毒X蛋白(hepatitis B virus X protein,HBx)是HBV相关肝细胞癌的关键调节因子,能够促进癌症的发生。许多长链非编码...; 关键词：原发性肝细胞癌长链非编码核糖核酸乙型肝炎病毒乙型肝炎病毒X蛋白

Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA: 《Genes & Diseases》2025年第1期238-249,共12页Jihua Ren Shengtao Cheng Fang Ren Huiying Gu Daiqing Wu Xinyan Yao Ming Tan Ailong Huang Juan Chen; supported by funds from the National Key R&D Program of China(No.2022YFA1303600);the National Natural Science Foundation of China(No.82273423,82202501);Scientific and Technological Research Program of Chongqing Municipal Education Commission of China(No.KJQN202100429);Natural Science Foundation Project of Chongqing,China(No.CSTB2022NSCQ-MSX0864);College Young Teachers Fund of the Fok Ying Tung Education Foundation(China)(No.171100).; Human hepatitis B virus(HBV)infection is the major cause of acute and chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.Although the application of prophylactic vaccination programs has successfully pre...; 关键词：CCCDNA Epigenetic regulation HBV HBX TRANSCRIPTION

乙型肝炎病毒蛋白HBx与宿主干扰素诱导因子的相互作用机制研究: 《中国科技成果》2024年第14期47-47,共1页谭广云宋红肖徐凤超肖庆飞李娜无; 国家自然科学基金青年基金项目“干扰素诱导基因TRIM5γ与HBx的相互作用对HBV复制的调控机制研究”(81401290)。; 乙型肝炎病毒(HBV)感染导致的疾病是困扰人类身心健康的一个普遍而重大的疾病卫生课题,HBV感染后将引发肝炎、肝纤维化,最终导致肝癌的产生.HBV的致病机理一直是一个热点及难点问题,全球约20亿左右的人感染过HBV,每年约有88.7万人死于HB...; 关键词：HBV感染肝纤维化相互作用机制干扰素诱导人类身心健康致病机理

Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX)genetransfected hepatic stellate cells: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期499-512,共14页Hongyi LIU Yuanyuan ZHOU Peng GUO Xiongwei ZHENG Weibin CHEN Shichao ZHANG Yu FU Xu ZHOU Zheng WAN Bin ZHAO Yilin ZHAO; supported by the National Natural Science Foundation of China(No.81770294);the Natural Science Foundation of Fujian Province(No.2023J05261),China.; Artificial vascular graft(AVG)fistula is widely used for hemodialysis treatment in patients with renal failure.However,it has poor elasticity and compliance,leading to stenosis and thrombosis.The ideal artificial bloo...; 关键词：Composite bilayer bionic blood vessel Extracellular matrix(ECM) Hepatic stellate cells(HSCs) Hepatitis B viral X(HBX)gene Mechanical force

Non-proteolytic ubiquitination of HBx controls HBV replication: 《Virologica Sinica》2024年第2期338-342,共5页Xiangpeng Sheng Yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying Dong Hui Kong Honghua Wang Ji Jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui Hu; funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(No.2019YFA0802103);the National Natural Science Foundation of China(No.92253302);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);athe Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006).; Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrh...; 关键词：INFECTION CIRRHOSIS

Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis: 《Journal of Molecular Cell Biology》2024年第4期31-44,共14页Hong-Juan You Qi Li Li-Hong Ma Xing Wang Huan-Yang Zhang Yu-Xin Wang En-Si Bao Yu-Jie Zhong De-Long Kong Xiang-Ye Liu Fan-Yun Kong Kui-Yang Zheng Ren-Xian Tang; supported by Xuzhou Technology Bureau Foundation(KC21065);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the Natural Science Foundation of Jiangsu Province(BK20211347);the National Natural Science Foundation of China(82372245);the Natural Science Foundation of the Jiangsu Higher Education Institutions(21KJA310004);an open Competition Grant of Xuzhou Medical University(JBGS202202).; Glutamate dehydrogenase 1(GLUD1)is implicated in oncogenesis.However,little is known about the relationship between GLUD1 and hepatocellular carcinoma(HCC).In the present study,we demonstrated that the expression leve...; 关键词：hepatocellular carcinoma HBX GLUD1 LASP1 SYVN1

HBV-HCC中HBx与免疫微环境的交互作用: 《西部医学》2024年第3期464-468,共5页刘青青王祥旭纪洪辰艾丽萍(综述) 张红梅(审校); 陕西省科技计划重点项目(2021JZ-35);西京医院学科助推项目(XJZT19ML21)。; 乙型肝炎病毒X蛋白(HBx)是乙型肝炎病毒X基因(HBX)将自身DNA整合至人基因组,进而合成的多功能蛋白。HBX基因的表达受肝细胞免疫、微环境和机体免疫的监视和调控,其表达的蛋白也可通过激活肝星状细胞、参与机体免疫调节、调控炎性细胞因...; 关键词：乙型肝炎病毒X基因(HBX) 乙型肝炎病毒X蛋白(HBx) 乙型肝炎病毒相关肝细胞癌(HBV-HCC) 肿瘤免疫微环境交互作用

HBx蛋白抑制乙型肝炎病毒诱导肝细胞表达Ⅰ型干扰素的研究: 《中国免疫学杂志》2024年第2期252-255,共4页潘颖杨凯陈谨孙蓓蓓田平平张发苏; 安徽省自然科学基金项目(2108085MH301);安徽省高校省级自然科学研究重点项目(KJ2020A0861)。; 目的:研究乙型肝炎病毒(HBV)对Ⅰ型干扰素表达的影响,并进一步探讨相关机制。方法:以HepG2细胞和稳转HBV基因组的HepG2.2.15细胞为模型,转染针对乙型肝炎病毒X(HBx)基因的小干扰RNA(siRNA)[HBx-siRNA]至HepG2.2.15细胞,转染HBx蛋白表达...; 关键词：乙型肝炎病毒 HBX蛋白 Ⅰ型干扰素 IRF3蛋白

LncRNA NKILA inhibits HBV replication by repressing NF-κB signalling activation: 《Virologica Sinica》2024年第1期44-55,共12页Xi Zhang Yuanyuan Li Chen Huan Yubao Hou Rujia Liu Hongyun Shi Peng Zhang Baisong Zheng Yingchao Wang Hong Wang Wenyan Zhang; supported in part by funding from the National Key R&D Program of China(2021YFC2301900,2021YFC2301903,and 2021YFC2301904);National Natural Science Foundation of China(81672004 and 81930062 to WZ;81801993 to HW);Science and Technology Department of Jilin Province(20190101003JH,20190201272JC,20200201331JC,and 20200201422JC);the Key Laboratory of Molecular Virology,Jilin Province(20102209);supported by Fundamental Research Funds for Central Universities.; Hepatitis B virus(HBV)infection results in liver cirrhosis and hepatocellular carcinoma(HCC).HBx/nuclear factor(NF)-κB pathway plays a role in HBV replication.However,whether NF-κB-interacting long noncoding RNA(NKI...; 关键词：LncRNA NF-κB-interacting longnoncoding RNA(NKILA) NF-ĸB signalling ChronichepatitisBvirus(HBV) Viral replication HBX

丹蒽醌通过MAPK-HNF4α信号通路抑制乙型肝炎病毒复制的作用机制研究: 《中药与临床》2024年第1期45-49,共5页陆鹏龚道银任亚利康鑫曹治兴; 国家自然科学基金(No.81873073,No.82174193,No.81973189,No.81891012,No.U19A2010);四川省自然科学基金(No.2022 NSFSC1535);杏林学者人才研究支持计划(CDUTCM)(QNXZ2018007,QNXZ2018011)。; 目的:本课题旨在研究丹蒽醌对HBV复制的抑制作用及其在体外抗HBV的分子机理。方法:运用MTT法检测丹蒽醌对Hep G2.2.15细胞的细胞毒性;利用Q-PCR检测丹蒽醌对Hep G2.2.15细胞内HBV DNA表达量的抑制效果;利用蛋白免疫印迹实验检测丹蒽醌对...; 关键词：丹蒽醌 HBV HBX HNF4α

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