Non-proteolytic ubiquitination of HBx controls HBV replication  

作　　者：Xiangpeng Sheng Yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying Dong Hui Kong Honghua Wang Ji Jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui Hu 

机构地区：[1]State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China [2]State Key Laboratory of Molecular Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China [3]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [4]Department of Thoracic Surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China [5]Shanghai Key Laboratory of Plant Molecular Sciences,College of Life Sciences,Shanghai Normal University,Shanghai 200234,China [6]Department of Pathogenic Biology,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China [7]School of Medicine,Guizhou University,Guiyang 550025,China [8]Key Laboratory of Medical Molecular Virology(MOE&MOH),School of Basic Medical Sciences,Fudan University,Shanghai 200032,China [9]Department of Hospital Infection Management,Department of Infectious Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [10]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Virologica Sinica》2024年第2期338-342,共5页中国病毒学（英文版）

基　　金：funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(No.2019YFA0802103);the National Natural Science Foundation of China(No.92253302);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);athe Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006).

摘　　要：Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.

关 键 词：INFECTION CIRRHOSIS 

分 类 号：R392[医药卫生—免疫学]