Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA  

作　　者：Jihua Ren Shengtao Cheng Fang Ren Huiying Gu Daiqing Wu Xinyan Yao Ming Tan Ailong Huang Juan Chen 

机构地区：[1]The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education,Chongqing Medical University,Chongqing 400000,China [2]Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400000,China

出　　处：《Genes & Diseases》2025年第1期238-249,共12页基因与疾病(英文)

基　　金：supported by funds from the National Key R&D Program of China(No.2022YFA1303600);the National Natural Science Foundation of China(No.82273423,82202501);Scientific and Technological Research Program of Chongqing Municipal Education Commission of China(No.KJQN202100429);Natural Science Foundation Project of Chongqing,China(No.CSTB2022NSCQ-MSX0864);College Young Teachers Fund of the Fok Ying Tung Education Foundation(China)(No.171100).

摘　　要：Human hepatitis B virus(HBV)infection is the major cause of acute and chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.Although the application of prophylactic vaccination programs has successfully prevented the trend of increasing HBV infection prevalence,the number of HBV-infected people remains very high.Approved therapeutic management efficiently suppresses viral replication;however,HBV infection is rarely completely resolved.The major reason for therapeutic failure is the persistence of covalently closed circular DNA(cccDNA),which forms viral minichromosomes by combining with histone and nonhistone proteins in the nucleus.Increasing evidence indicates that chromatin-modifying enzymes,viral proteins,and noncoding RNAs are essential for modulating the function of cccDNA.Therefore,a deeper understanding of the regulatory mechanism underlying cccDNA transcription will contribute to the development of a cure for chronic hepatitis B.This review summarizes the current knowledge of cccDNA biology,the regulatory mechanisms underlying cccDNA transcription,and novel anti-HBV approaches for eliminating cccDNA transcription.

关 键 词：CCCDNA Epigenetic regulation HBV HBX TRANSCRIPTION 

分 类 号：R51[医药卫生—内科学]