HEPATOCARCINOGENESIS

作品数：126被引量：854H指数：15
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相关机构：第二军医大学香港中文大学广州军区广州总医院首都医科大学附属北京佑安医院更多>>
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Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT
《Oncology Research》2025年第5期1121-1133,共13页WENYING ZHENG YANYAN SHANG KAI DU AILING LUO LIJUN PEI MEIQI LI GUOPING ZHANG MIN DENG 
supported by the National Natural Science Foundation of China(Nos.81972771,82173062);the Key Areas Project of Education Department of Guangdong Province(No.2021ZDZX2017);the Tertiary Education Scientific Research Project of Guangzhou Municipal Education Bureau(No.202235387);the Guangzhou Science and Technology Project of Guangzhou Municipal Science and Technology Bureau(No.2023A03J0428);the Natural Science Foundation of Guangdong Province,China(No.2024A1515013082);the Guangdong Basic and Applied Basic Research 21 Foundation(No.2021A1515010403).
Background:Alterations in splicing factors contribute to aberrant alternative splicing(AS),which subsequently promotes tumor progression.The splicing factor polypyrimidine tract binding protein 1(PTBP1)has been shown ...
关键词：Hepatocellular carcinoma Alternative splicing PTBP1 MAPT 
The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis
《Genes & Diseases》2025年第2期60-63,共4页Yang Liu Feifei Song Xianhuang Zeng Siqi Yang Zixu Zhai Ze Wang Wajeeha Naz Tanzeel Yousaaf Junwei Sun Yangjun Zhang Ying Zhou Mingxiong Guo Yun-Bo Shi Geng Tian Guihong Sun 
supported by the National Natural Science Foundation of China (No.81572447,31871427,32260173);Zhongnan Hospital-Taikang Medical School (School of Basic Medical Sciences)of Wuhan University Joint Foundation (No.JCZN2022010);supported by the intramural program of Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD),National Institutes of Health (NIH),USA.
Sex-determining region Y-box protein 3(SOX3)is a member of the SoxB1 transcription factors subfamily including SOX1 and sox2,first identified based on homology to the high mobility box.1 The oncogenic potential of the...
关键词：inconsistent HEPATOCELLULAR MTOR 
Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma被引量：1
《World Journal of Hepatology》2024年第12期1480-1492,共13页Jun-Ling Yang Jie Yang Rong-Fei Fang Wen-Li Sai Deng-Fu Yao Min Yao 
Supported by the National Natural Science Foundation of China,No.32470985 and No.81673241.
BACKGROUND Angiopoietin-2(Ang-2)level is related to hepatocellular carcinoma(HCC)pro-gression.However,the dynamic expression and regulatory mechanism of Ang-2 remain unclear.AIM To investigate Ang-2 levels in chronic ...
关键词：ANGIOPOIETIN-2 Hypoxia-inducible factor-1α HEPATOCARCINOGENESIS Dynamic model Metastasis 
Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis
《Cancer Communications》2024年第10期1106-1129,共24页Dae-Hwan Kim Minjeong Sung Myong-Suk Park Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung 
Bio&Medical Technology Development Program of the National Research Foundation,Grant/Award Numbers:NRF-2020M3A9G3080281,NRF-2020R1A5A2031185;Korean Government。
Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming gro...
关键词：F-ACTIN FAK hepatic carcinogenesis IntegrinαV Interferonα JUNB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-Β1 
miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4
《BIOCELL》2024年第7期1071-1079,共9页XULONG SUN WENTAO DING CHAO JIANG ZHIAN FANG 
Introduction:Hepatocellular carcinoma(HCC),a prevalent malignancy,poses significant challenges with high tumor heterogeneity and poor prognosis.MicroRNAs(miRNAs)play a pivotal role in hepatocarcinogenesis.Although abno...
关键词：Hepatocellular carcinoma miR-557 Chromobox 4 HEPATOCARCINOGENESIS 
Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2024年第6期2350-2361,共12页Min Yao Rong-Fei Fang Qun Xie Min Xu Wen-Li Sai Deng-Fu Yao 
Supported by National Natural Science Foundation of China,No.81673241 and No.31872738;Nantong Infectious Disease Alliance Fund,No.202308001.
The prevention and early diagnosis of liver cancer remains a global medical challenge.During the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility...
关键词：HEPATOCARCINOGENESIS Cell signals Specific biomarkers Early diagnosis 
Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease
《Science China(Life Sciences)》2024年第6期1183-1198,共16页Shiman Jiang Lvwan Xu Yanfei Chen Zheyue Shu Longxian Lv Yuxi Zhao Kefan Bi Sisi Yang Qiangqiang Wang Lanjuan Li 
supported by the National Natural Science Foundation of China(81790631);the National Key Research and Development Program of China(2022YFC3602000);the Shandong Provincial Laboratory Project(SYS202202);Research Project of Jinan Micro-ecological Biomedicine Shandong Laboratory(JNL-2022009B,JNL-2022047D)。
Liver disease,a major health concern worldwide,is a serious and progressive disorder.Herein,we not only established a mouse model of DEN+CCl4-induced primary liver disease but also collected clinical human samples to ...
关键词：gut mycobiome liver disease longitudinal studies HEPATOCARCINOGENESIS fungal biomarker 
Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis
《Journal of Molecular Cell Biology》2024年第4期31-44,共14页Hong-Juan You Qi Li Li-Hong Ma Xing Wang Huan-Yang Zhang Yu-Xin Wang En-Si Bao Yu-Jie Zhong De-Long Kong Xiang-Ye Liu Fan-Yun Kong Kui-Yang Zheng Ren-Xian Tang 
supported by Xuzhou Technology Bureau Foundation(KC21065);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the Natural Science Foundation of Jiangsu Province(BK20211347);the National Natural Science Foundation of China(82372245);the Natural Science Foundation of the Jiangsu Higher Education Institutions(21KJA310004);an open Competition Grant of Xuzhou Medical University(JBGS202202).
Glutamate dehydrogenase 1(GLUD1)is implicated in oncogenesis.However,little is known about the relationship between GLUD1 and hepatocellular carcinoma(HCC).In the present study,we demonstrated that the expression leve...
关键词：hepatocellular carcinoma HBX GLUD1 LASP1 SYVN1 
Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis被引量：3
《Hepatobiliary & Pancreatic Diseases International》2023年第3期263-269,共7页Min Yao Jian-Jun Wang Xi-Yu Chen Wen-Li Sai Jie Yang De-Feng Wang Li Wang Deng-Fu Yao 
supported by grants from the Natural Science Foundation of China(81873915,31872738 and 81673241);Nantong S&T Key Plan(MS12019021);NTU Medical Program of China(TDYX2021010)。
Background:The effective treatment for hepatocellular carcinoma(HCC)depends on early diagnosis.Previously,the abnormal expression of Wnt3a as the key signaling molecule in the Wnt/β-catenin pathway was found in HCC c...
关键词：HEPATOCARCINOGENESIS Dynamic expression MONITORING Model 
From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H_(2)O_(2) and targeting nanotherapeutics被引量：1
《Bioactive Materials》2023年第5期187-205,共19页Meiyu Shao Yifan Wang Hongyan Dong Lu Wang Xiaoqing Zhang Xin Han Xianan Sang Yini Bao Mengyun Peng Gang Cao 
This work was financially supported by the National Natural Science Foundation of China(Nos.52003246,81922073 and 81973481);the Traditional Chinese Medicine Key Scientific Research Fund Project of Zhejiang Province(Nos.2018ZY004,2022ZQ032 and 2021ZZ009);the Youth Natural Science Program of Zhejiang Chinese Medical University(2021JKZKTS007A).
Liver fibrosis and hepatocellular carcinoma(HCC)have been worldwide threats nowadays.Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic stage.In pathological liver,excessiv...
关键词：Liver fibrosis HEPATOCARCINOGENESIS Nanotherapeutics H_(2)O_(2)accumulation Oxidative stress 
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