From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H_(2)O_(2) and targeting nanotherapeutics  

作　　者：Meiyu Shao Yifan Wang Hongyan Dong Lu Wang Xiaoqing Zhang Xin Han Xianan Sang Yini Bao Mengyun Peng Gang Cao 

机构地区：[1]School of Pharmacy,Zhejiang Chinese Medical University,Hangzhou,310000,PR China

出　　处：《Bioactive Materials》2023年第5期187-205,共19页生物活性材料（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.52003246,81922073 and 81973481);the Traditional Chinese Medicine Key Scientific Research Fund Project of Zhejiang Province(Nos.2018ZY004,2022ZQ032 and 2021ZZ009);the Youth Natural Science Program of Zhejiang Chinese Medical University(2021JKZKTS007A).

摘　　要：Liver fibrosis and hepatocellular carcinoma(HCC)have been worldwide threats nowadays.Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic stage.In pathological liver,excessive H_(2)O_(2) is generated and accumulated,which impacts the functionality of hepatocytes,Kupffer cells(KCs)and hepatic stellate cells(HSCs),leading to genesis of fibrosis and HCC.H_(2)O_(2) accumulation is associated with overproduction of superoxide anion(O_(2)^(·-))and abolished antioxidant enzyme systems.Plenty of therapeutics focused on H_(2)O_(2) have shown satisfactory effects against liver fibrosis or HCC in different ways.This review summarized the reasons of liver H_(2)O_(2) accumulation,and the role of H_(2)O_(2) in genesis of liver fibrosis and HCC.Additionally,nanotherapeutics targeting H_(2)O_(2) were summarized for further consideration of antifibrotic or antitumor therapy.

关 键 词：Liver fibrosis HEPATOCARCINOGENESIS Nanotherapeutics H_(2)O_(2)accumulation Oxidative stress 

分 类 号：R735.7[医药卫生—肿瘤]