云南高校图书馆联盟文献共享服务平台- F-ACTIN

F-ACTIN: 作品数：175被引量：353H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：唐万欣林珏龙徐邦牢柳飞陈耀文更多>>; 相关机构：四川大学中国医科大学重庆医科大学吉林大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金广东省医学科学技术研究基金更多>>

Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis: 《Cancer Communications》2024年第10期1106-1129,共24页Dae-Hwan Kim Minjeong Sung Myong-Suk Park Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung; Bio&Medical Technology Development Program of the National Research Foundation,Grant/Award Numbers:NRF-2020M3A9G3080281,NRF-2020R1A5A2031185;Korean Government。; Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming gro...; 关键词：F-ACTIN FAK hepatic carcinogenesis IntegrinαV Interferonα JUNB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-Β1

Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation: 《Life Metabolism》2024年第5期32-37,共6页Wei Zhang Mengxiao Wang Enci Wang Wei Lu Zengxia Li Yuchong Zhang Gaofei Hu Qi Zhang Wenxin Shan Yongjun Dang Zhe Zhao Lemin Zheng Weiguo Fu Lixin Wang; supported by the National Natural Science Foundation of China(81970412,81772962,and 81970425);Xiamen Municipal Health Science and Technology Program Fund(3502Z20194034);the National High Technology Research and Development Program of China(2020YFA0803700);the Clinical Medicine Plus X-Young Scholars Project,Peking University,the Fundamental Research Funds for the Central Universities(PKU2023LCXQ015).; Dear Editor,Aortic dissection(AD)is a fatal disease caused by dysfunction of elastin contractile units,which are composed of extracellular matrix(ECM)and aortic smooth muscle cells(AoSMCs),and eventual disruption of a...; 关键词：stiffness AORTIC DISSECTION

miR-7641通过调控SATB2对乳腺癌细胞活性及骨架蛋白表达的作用及机制: 《中国老年学杂志》2024年第18期4511-4515,共5页邵建强王鹏张勤白杰李会欣王遵义; 河北省卫生健康委医学科学研究项目(No.20200307)。; 目的探究微小RNA(miR)-7641通过调控核基质结合蛋白质(SATB)2对乳腺癌细胞活性及骨架蛋白表达的影响。方法将MCF-7细胞分为MCF-7组、miR-7641组、miR-NC组和pcDNA-SATB2组。反转录实时荧光定量-聚合酶链反应(PCR)法检测人正常乳腺上皮...; 关键词：微小RNA(miR)-7641 核基质结合蛋白质(SATB)2 乳腺癌增殖侵袭凋亡骨架蛋白纤维状肌动蛋白(F-actin)

机械拉伸通过Piezo1/F-actin/YAP通路促进骨髓间充质干细胞迁移: 《医用生物力学》2024年第S01期410-410,共1页马宁黄蕾周倩旭罗庆宋关斌; 国家自然科学基金项目,12272070; 目的探究机械拉伸对间充质干细胞(mesenchymal stem cells,MSCs)迁移能力的影响及相关分子机理,为深入认识力学调节MSCs迁移的机制提供实验证据。方法采用全骨髓贴壁法提取和分离SD大鼠MSCs,使用机械拉伸加载装置在体外对MSCs施加时间为...; 关键词：机械拉伸骨髓间充质干细胞加载装置免疫荧光染色全骨髓贴壁法实验证据提取和分离

Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling:a review: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第4期280-292,共13页Siyi LIN Xinyu HE Ying WANG Yu CHEN Aifu LIN; supported by the National Natural Science Foundation for Distinguished Young Scholars of China(No.32225014);the“Lingyan”R&D Research and Development Project(No.2023C03023);the National Key R&D Program of China(No.2021YFC2700903);the National Natural Science Foundation of China(Nos.81672791 and 81872300);the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(No.LR18C060002)。; Cells within tissues are subject to various mechanical forces,including hydrostatic pressure,shear stress,compression,and tension.These mechanical stimuli can be converted into biochemical signals through mechanorecep...; 关键词：YAP/TAZ Long non-coding RNA(lncRNA) MECHANOTRANSDUCTION F-ACTIN

Mechanotransduction in distinct F-actin architectures:a novel molecular tension sensor revealing cellular mechanical anisotropy: 《Mechanobiology in Medicine》2024年第1期4-6,共3页Ting Liang Bin Li; supported by National Natural Science Foundation of China(32201070).; Mechanotransduction is essential for cell fate and behavior,and F-actin plays a key role in the generation and transmission of molecular forces.A recent study published in Nature Communication presented a novel highpr...; 关键词：Mechanotransducton F-ACTIN Tension sensor Mechanical anisotropy Traction force microscopy

Plectin通过诱导F-actin聚合增强肝癌细胞的迁移能力: 《四川大学学报（医学版）》2024年第1期60-66,共7页徐茹霜杨凌霄宋关斌; 国家自然科学基金重点项目(No.11832008)资助。; 目的研究Plectin的表达与肝癌细胞迁移能力的关系,揭示Plectin表达影响肝癌细胞迁移行为的分子机理。方法首先,Western blot检测正常肝细胞和肝癌细胞中Plectin的表达。其次,构建Plectin下调的肝癌细胞株,设立对照组(shNC组)和shPLEC组...; 关键词：PLECTIN 肝癌细胞细胞迁移分析上皮-间质转化细胞骨架 F-ACTIN

Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis被引量：2: 《Research》2023年第4期321-335,共15页Xinmiao Ji Xiaofei Tian Shuang Feng Lei Zhang Junjun Wang Ruowen Guo Yiming Zhu Xin Yu Yongsen Zhang Haifeng Du Vitalii Zablotskii Xin Zhang; This work was supported by the National Natural Science Foundation of China(U21A20148,52007185,and 31900506);International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052);the CASHIPS Director’s Fund(2021YZGH04,BJPY2021A06,and YZJJZX202014);A portion of this work was supported by the High Magnetic Field Laboratory of Anhui Province(AHHMFX-2021-05);the Heye Health Technology Chong Ming Project under award number(HYCMP2021010);Operational Programme Research,Development and Education as well as financed by the European Structural and Investment Funds and the Czech Ministry of Education,Youth and Sports through Project No.SOLID21-CZ.02.1.01/0.0/0.0/16_019/0000760;the CAS president’s international fellowship initiative(PIFI)grant(2022VMA0009)。; F-actin(filamentous actin)has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment,migration,and cancer metastasis,but there are very limited ways to perturb F-actin dynamics wit...; 关键词：METASTASIS INVASION cancer

CXCR5 Regulates Neuronal Polarity Development and Migration in the Embryonic Stage via F‑Actin Homeostasis and Results in Epilepsy‑Related Behavior: 《Neuroscience Bulletin》2023年第11期1605-1622,共18页Zhijuan Zhang Hui Zhang Ana Antonic‑Baker Patrick Kwan Yin Yan Yuanlin Ma; supported by grants from the Science and Technology Program of Chongqing of China(cstc2018jcyjAX003);the National Natural Science Foundation of China(81901322 and 82271497).; Epilepsy is a common,chronic neurological disorder that has been associated with impaired neurodevelopment and immunity.The chemokine receptor CXCR5 is involved in seizures via an unknown mechanism.Here,we first deter...; 关键词：EPILEPSY CXCR5 Embryonic neurogenesis Pluripotent stem cells Intrauterine electroporation F-ACTIN Neuronal polarity Neuronal migration

海分枝杆菌embA低表达菌株的构建及巨噬细胞侵染实验被引量：1: 《复旦学报（自然科学版）》2023年第5期585-594,共10页李烨雨刘含梅黄滢睿郭滨张鹭; “十四五”国家重点研发计划(2021YFC2301500)。; 通过CRISPRi基因编辑技术构建阿拉伯糖基转移酶基因A(embA)低表达海分枝杆菌突变株,利用qRT-PCR技术检测相关基因转录水平。突变株侵染巨噬细胞后,台盼蓝染色测定细胞存活率,稀释涂布法检测胞内活菌数量。免疫荧光染色观察感染后巨噬细...; 关键词：海分枝杆菌 EMBA 巨噬细胞髓样分化因子88 F-ACTIN

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