Mechanotransduction in distinct F-actin architectures:a novel molecular tension sensor revealing cellular mechanical anisotropy  

作　　者：Ting Liang Bin Li 

机构地区：[1]Medical 3D Printing Center,Orthopedic Institute,Department of Orthopedic Surgery,The First Affiliated Hospital,School of Biology and Basic Medical Sciences,Suzhou Medical College,Soochow University,Suzhou,Jiangsu 215000,PR China

出　　处：《Mechanobiology in Medicine》2024年第1期4-6,共3页力学生物学与医学（英文）

基　　金：supported by National Natural Science Foundation of China(32201070).

摘　　要：Mechanotransduction is essential for cell fate and behavior,and F-actin plays a key role in the generation and transmission of molecular forces.A recent study published in Nature Communication presented a novel highprecision molecular tension measurement method using a Forster resonance energy transfer-based tension sensor with separated load-bearing function within distinct F-actin structures,and demonstrated that cellular mechanical anisotropy depends on cell shape,loading direction,and magnitude.

关 键 词：Mechanotransducton F-ACTIN Tension sensor Mechanical anisotropy Traction force microscopy 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]