Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling:a review  

作　　者：Siyi LIN Xinyu HE Ying WANG Yu CHEN Aifu LIN 

机构地区：[1]College of Medicine,Zhejiang University,Hangzhou 310058,China [2]College of Life Sciences,Zhejiang University,Hangzhou 310058,China [3]Cancer Center,Zhejiang University,Hangzhou 310058,China [4]Key Laboratory for Cell and Gene Engineering of Zhejiang Province,Hangzhou 310058,China [5]International School of Medicine,International Institutes of Medicine,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,Yiwu 322000,China [6]Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Hangzhou 310058,China [7]Future Health Laboratory,Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314100,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第4期280-292,共13页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation for Distinguished Young Scholars of China(No.32225014);the“Lingyan”R&D Research and Development Project(No.2023C03023);the National Key R&D Program of China(No.2021YFC2700903);the National Natural Science Foundation of China(Nos.81672791 and 81872300);the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(No.LR18C060002)。

摘　　要：Cells within tissues are subject to various mechanical forces,including hydrostatic pressure,shear stress,compression,and tension.These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes,shaping the microenvironment and maintaining cellular physiological balance.Several studies have demonstrated the roles of Yes-associated protein(YAP)and its homolog transcriptional coactivator with PDZ-binding motif(TAZ)as mechanotransducers,exerting dynamic influence on cellular phenotypes including differentiation and disease pathogenesis.This regulatory function entails the involvement of the cytoskeleton,nucleoskeleton,integrin,focal adhesions(FAs),and the integration of multiple signaling pathways,including extracellular signal-regulated kinase(ERK),wingless/integrated(WNT),and Hippo signaling.Furthermore,emerging evidence substantiates the implication of long non-coding RNAs(lncRNAs)as mechanosensitive molecules in cellular mechanotransduction.In this review,we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical stimuli.Additionally,we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.

关 键 词：YAP/TAZ Long non-coding RNA(lncRNA) MECHANOTRANSDUCTION F-ACTIN 

分 类 号：R737.9[医药卫生—肿瘤]