Mitochondrial quality control in human health and disease  

作　　者：Bo‑Hao Liu Chen‑Zhen Xu Yi Liu Zi‑Long Lu Ting‑Lv Fu Guo‑Rui Li Yu Deng Guo‑Qing Luo Song Ding Ning Li Qing Geng 

机构地区：[1]Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China [2]Department of Thoracic Surgery,First Hospital of Jilin University,Changchun 130021,China

出　　处：《Military Medical Research》2025年第3期393-458,共66页军事医学研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).

摘　　要：Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.

关 键 词：Mitochondrial quality control(MQC) METABOLISM Programmed cell death CANCER Cardiovascular disease Metabolic disease Nervous disease Pulmonary disease Kidney disease Digestive system disease 

分 类 号：R363[医药卫生—病理学]