Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease  

作　　者：Juan Yang Jiahui Zhang Le Zhang Zhenshan Yang 

机构地区：[1]Department of Neonatology,The Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi Children’s Hospital,Wuxi,214000,China [2]Department of Neonatology,Affiliated Children’s Hospital of Jiangnan University,Wuxi Children’s Hospital,Wuxi,214023,China [3]Department of Pediatric Laboratory,Affiliated Children’s Hospital of Jiangnan University,Wuxi Children’s Hospital,Wuxi,214023,China [4]Division of Oncology,Department of Clinical Sciences Lund,Lund University,Lund,22381,Sweden

出　　处：《BIOCELL》2025年第3期399-417,共19页生物细胞(英文)

基　　金：supported by grants from the Top Medical Expert Team of Wuxi Taihu Talent Plan(Grant Nos.DJTD202106,GDTD202105 and YXTD202101);Medical Key Discipline Program of Wuxi Health Commission(Grant Nos.ZDXK2021007 and CXTD2021005);Top Talent Support Program for Young and MiddleAged People of Wuxi Health Committee(Grant No.BJ2023090);Scientific Research Program of Wuxi Health Commission(Grant Nos.Z20210 and M202208).

摘　　要：With the prevalence of obesity,metabolic dysfunction-associated steatotic liver disease(MASLD)has become the most common chronic liver disease worldwide and can cause a series of serious complications.The pathogenesis of MASLD is complex,characterized by oxidative stress,impaired mitochondrial function and lipid metabolism,and cellular inflammation.Mitochondrial biology and function are central to the physiology of the liver.It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression.Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD.In this review,we aim to focus on the recent advances in understanding mitochondrial oxidative stress-related mechanisms in the progression of MASLD.The in-depth elaboration of its related mechanisms is hoped to help find effective methods for treating MASLD.

关 键 词：Oxidative stress MASLD mitochondrial dysfunction mitochondrial quality control ER-mitochondria association 

分 类 号：R57[医药卫生—消化系统]