云南高校图书馆联盟文献共享服务平台- COHESIN

COHESIN: 作品数：24被引量：54H指数：5; 导出分析报告; 相关领域：生物学更多>>; 相关作者：俞亚芬许宝山刘媛媛赵光年刘国友更多>>; 相关机构：上海交通大学山东师范大学中山大学中国科学院更多>>; 相关期刊：《Signal Transduction and Targeted Therapy》《遗传》《中华微生物学和免疫学杂志》《中国科学：生命科学》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目协和青年科研基金更多>>

Affinity-induced covalent protein-protein ligation via the SpyCatcherSpyTag interaction被引量：3: 《Green Carbon》2023年第1期33-42,共10页Jacob O.Fierer Omar E.Tovar-Herrera Jonathan Y.Weinstein Amaranta Kahn Sarah Moraïs Itzhak Mizrahi Edward A.Bayer; Production of economically viable bioethanol is potentially an environmentally and financially worthwhile endeavor.One major source for fermentable sugars is lignocellulose.However,lignocellulosic biomass is difficult...; 关键词：Synthetic Biology Protein Ligation Cellulosomes COHESIN DOCKERIN Protein Engineering Cellulose Degradation

RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits被引量：1: 《Protein & Cell》2023年第1期51-63,共13页Yue Lv Gang Lu Yuling Cai Ruibao Su Liang Liang Xin Wang Wenyu Mu Xiuqing He Tao Huang Jinlong Ma Yueran Zhao Zi-Jiang Chen Yuanchao Xue Hongbin Liu Wai-Yee Chan; supported by grants from the National Key R&D Program of China(2021YFC2700200);Academic Promotion Programme of Shandong First Medical University(2019U001);General Research Fund from Research Grants Council of Hong Kong(14103418);Basic Science Center Program of NFSC(31988101);the Shandong Provincial Key Research and Development Program(2020ZLYS02);a fund from A-Smart Group to support CUHKSDU Joint Laboratory on Reproductive Genetics of CUHK,Major Innovation Projects in Shandong Province(2021ZDSYS16);the Science Foundation for Distinguished Yong Scholars of Shandong(ZR2021JQ27);Taishan Scholars Program for Young Experts of Shandong Province(tsqn202103192).; RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain unknown.Here,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRN...; 关键词：RBM46 LACE-seq RNA-binding protein MEIOSIS COHESIN

T细胞受体基因Tcra和Tcrd的重排过程及其调节机制: 《中华微生物学和免疫学杂志》2022年第9期737-743,共7页朱永常郝冰涛; 国家自然科学基金(32170885,31970836)。; T细胞受体(T cell receptor,TCR)的高度多样性是其识别抗原的基础,在适应性免疫中发挥重要作用。TCR多样性来自胸腺T细胞发育过程中的V(D)J重排。在4个TCR基因中,Tcra和Tcrd基因位于同一个基因座,共用特定的V基因,因此其重排和调节具有...; 关键词：T细胞受体基因 V(D)J重排染色质构象 CTCF-Cohesin RAG

Age-cumulative Effect of REC8 Reduction on Meiotic Chromosome Segregation Errors in Mice: 《Reproductive and Developmental Medicine》2021年第4期193-198,共6页Li-Yuan Tian Ling Zhang Cheng-Qiu Tao Xiao-Qi Lin Feng Zhang Bin Zhang; Shanghai Municipal Science and Technology Major Project(2017 SHZDZX01)。; Objective:This study aimed to explore the relationship between cohesin subunit REC8 reduction and meiosis chromosome segregation errors in the ovary.Methods:Rec8^(+/-)mice were generated using CRIPSR/Cas9 gene editing...; 关键词：Chromosome Segregation Errors COHESIN MEIOSIS REC8

PD-L1 regulates genomic stability via interaction with cohesin-SAl in the nucleus被引量：1: 《Signal Transduction and Targeted Therapy》2021年第3期608-610,共3页Wen Zhang Jiali Jin Yanjin Wang Lan Fanq Liu Min Xinbo Wang Lin Ding Linjun Weng Tan Xiao Tianhua Zhou Ping Wang; Dear Editor,Programmed death ligand-1(PD-L1)is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells,inhibits T cell activity and proliferation,facilitates cancer cells t...; 关键词：CANCER DEATH INTERACTION

Cohesion介导的减数分裂异常与卵子老化发生的关系: 《生理科学进展》2021年第1期33-36,共4页李丽李凯杨洋蔡靓尹萍宗道宽童国庆张武文; 国家自然科学基金(81571442)资助课题。; 社会发展及计划生育政策的顺势改变,使得高龄女性的生育需求不断扩大,但与年龄相关的卵子老化是高龄女性急需解决的生育难题,而造成卵子老化的主因确是卵母细胞非整倍体发生率的增加。粘连蛋白(cohesin)能够介导姐妹染色单体之间的着丝...; 关键词：COHESIN 高龄卵子老化减数分裂异常

Why is oocyte aneuploidy increased with maternal aging?被引量：12: 《Journal of Genetics and Genomics》2020年第11期659-671,共13页Jun-Yu Ma Sen Li Lei-Ning Chen Heide Schatten Xiang-Hong Ou Qing-Yuan Sun; supported by the National Natural Science Foundation of China(31801245,81671425 and 81971357);Key Research&Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2019GZR110104001); One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy,which is increased with maternal aging.Numerous possible causes of oocyte aneuploidy in aged women have been proposed,including cross...; 关键词：AGING OOCYTE ANEUPLOIDY COHESIN SAC Spindle Mitochondria MEIOSIS DNA damage

RFX5调控原钙粘蛋白α基因簇的表达被引量：7: 《遗传》2020年第8期760-774,共15页王娜甲芝莲吴强; 国家自然科学基金项目(编号:91640118,31630039)资助。; 基因的表达调控与基因组在细胞核内的三维空间架构相辅相成,原钙粘蛋白(protocadherin,Pcdh)基因簇在大脑发育中起到关键作用,可以作为研究基因表达调控机制的模式基因。转录因子RFX5(regulatory factor x 5)是翼螺旋家族(winged HLH fa...; 关键词：RFX5 Pcdh CTCF COHESIN CRISPR/Cas9

Cohesin结构及功能研究进展被引量：5: 《遗传》2020年第1期57-72,共16页张雨方玉达; 国家自然科学基金项目(编号：31871230)资助~~; Cohesin是一类在真核生物进化过程中保守的蛋白复合体,由4个重要亚基相互作用形成环状结构,在细胞分裂过程中参与维持染色体的有序排布。在动物中研究发现cohesin还可以作为分子间的连结器介导绝缘子/增强子–启动子间长距离交互,导致...; 关键词：SMC COHESIN 细胞周期三维基因组转录调控

Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin被引量：9: 《Protein & Cell》2019年第12期914-920,共7页Yujia Lu Jia Shou Zhilian Jia Yonghu Wu Jinhuan Li Ya Guo Qiang Wu; This work was supported by Grants from MOST(2017YFA0504203,2018YFC1004504);the National Natural Science Foundation of China(31630039,91640118,and 31470820)to Q.W.Q.W.is a Shanghai Subject Chief Scientist.; Dear Editor,Similar to higher-order folding of polypeptide chains into functional proteins,linear DNA molecules are spatially folded in a hierarchical and dynamic manner into three-dimensional(3D)functional chromatin ...; 关键词：ASYMMETRIC precise CHAINS

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