PLASTICITY

作品数：779被引量：1953H指数：17
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Metabolic reprogramming of astrocytes:Emerging roles of lactate
《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning 
supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...
关键词：ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment 
Extracellular vesicles:multiple signaling capabilities and translation into promising therapeutic targets to promote neuronal plasticity
《Neural Regeneration Research》2025年第12期3521-3522,共2页Dirk M.Hermann Bernd Giebel 
supported by the German Research Foundation(grants 514990328,389030878,405358801/428817542(within FOR2879)and 449437943(within TRR332,project C06);German Federal Ministry of Education and Science(3DOS,grant 161L0278B)(to DMH)。
Extracellular vesicles(EVs)are cell-derived,lipid membrane-enclosed vesicles carrying a broad spectrum of biologically active molecules(including proteins,RNAs,and bioactive lipids)which play important roles in interc...
关键词：PLASTICITY OXIDATIVE SPECTRUM 
Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord被引量：1
《Neural Regeneration Research》2025年第7期2095-2107,共13页Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub 
supported by the Department of Defense AFIRMⅢW81XWH-20-2-0029 grant subcontract;Lone Star Paralysis gift,UT POC19-1774-13 grant;Neuraptive Therapeutics Inc.26-7724-56 grant;National Institutes of Health R01-NS128086(all to GDB)。
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene g...
关键词：AXOTOMY dorsal horn peripheral nerve injury PLASTICITY polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase 
Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms
《Neural Regeneration Research》2025年第7期1995-1996,共2页Rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho 
supported by PTDC-01778/2022-NeuroDev3D,iNOVA4Health(UIDB/04462/2020 and UIDP/04462/2020);LS4FUTURE(LA/P/0087/2020)。
Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid compositi...
关键词：PLASTICITY STRUCTURAL MECHANISMS 
Dynamics of epithelial-mesenchymal plasticity driving cancer drug resistance
《Cancer Pathogenesis and Therapy》2025年第2期120-128,共9页Rashmi Bangarh Reena V.Saini Adesh K.Saini Tejveer Singh Hemant Joshi Seema Ramniwas Moyad Shahwan Hardeep Singh Tuli 
supported by the DST-INSPIRE(Department of Science&Technology-Innovation in Science Pursuit for Inspired Research)Fellowship(No.IF210078);the Department of Science and Technology(Technology Development Program),Government of India(No.TDP/BDTD/54/2021/General);the Indian Council of Medical Research-Department of Health Research(ICMR-DHR)Young Scientist Fellowship(F.No:R.12014/29/2022/HR).
Epithelial-mesenchymal transition(EMT)promotes several cancers by increasing tumor cell motility,disrupting epithelial cell phenotypes,apical-basal polarity,and intracellular connections,and enhancing tumor resistance...
关键词：Epithelial-mesenchymal transition Tumor microenvironment METASTASIS Cancer drug resistance 
A Novel BCC/B2 Structural Nb_(38)Ti_(35)Al_(15)V_(6)Cr_(4)(TaHfMoW)_(2) Refractory High‑Entropy Alloy with Excellent Specifc Yield Strength‑Plasticity Synergy
《Acta Metallurgica Sinica(English Letters)》2025年第3期396-406,共11页Hongbin Liu Zhenqiang Xing Yitong Yang Jingyu Pang Wen Li Zhengwang Zhu Long Zhang Aimin Wang Haifeng Zhang Hongwei Zhang 
supported by the Chinese Academy of Sciences(ZDBS-LY-JSC023),the National Natural Science Foundation of China(No.52404370);the Natural Science Foundation of Liaoning Province(2023-BS-012);the Youth Innovation Promotion Association CAS(2021188);the IMR Innovation Fund(2023-PY16);the Guangdong Basic and Applied Basic Research Foundation(2023A1515111060).
Refractory high-entropy alloys(RHEAs)stand as promising candidates for the development of a new generation of hightemperature materials due to their exceptional mechanical properties.However,the inherent low ductility...
关键词：Refractory high entropy alloy B2 phase Microstructure Mechanical property Deformation mechanism 
Responses of yield,root traits and their plasticity to the nitrogen environment in nitrogen-efficient cultivars of drip-irrigated rice
《Journal of Integrative Agriculture》2025年第2期480-496,共17页Qingyun Tang Guodong Wang Lei Zhao Zhiwen Song Yuxiang Li 
supported by the National Natural Science Foundation of China(31860345 and 31460541);the Youth Innovative Top Talents Project of Shihezi University,China(CXBJ202003);the Third Division of Xinjiang Production and Construction Corps Scientific and Technological Achievements Transfer and Transformation Project,China(KJ2023CG03)。
The responses of drip-irrigated rice physiological traits to water and fertilizers have been widely studied.However,the responses of yield,root traits and their plasticity to the nitrogen environment in different nitr...
关键词：drip irrigation rice nitrogen environment root traits PLASTICITY YIELD nitrogen use efficiency 
Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer
《Chinese Journal of Cancer Research》2025年第1期90-114,共25页Tao Ding Lina He Guowen Lin Lei Xu Yanjun Zhu Xinan Wang Xuefei Liu Jianming Guo Fanghong Lei Zhixiang Zuo Jianghua Zheng 
supported by Shanghai Science and Technology Commission,China(No.21S11902100);Shanghai Municipal Health Commission Scientific Research Project(No.202140308);Clinical Research Project of Tongji Hospital of Tongji University[No.ITJ(ZD)2209];Shanghai Tongji Hospital National Natural Science Foundation Cultivation Project(No.GJPY2216);Shanghai Medical Innovation Research Special Foundation(No.23Y11908800);CSCO-Haosen Oncology Research Fund(No.Y-HS202301-0096).
Objective:Prostate cancer(PCa)is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment(TME)and high tumor heterogeneity,which challenges clinically stratified management and ...
关键词：Single-cell RNA sequencing prostate cancer lineage plasticity tumor heterogeneity molecular classification 
From mice to humans:a need for comparable results in mammalian neuroplasticity
《Neural Regeneration Research》2025年第2期464-466,共3页Marco Ghibaudi Enrica Boda Luca Bonfanti 
supported by Progetto Trapezio,Compagnia di San Paolo(67935-2021.2174)to LB,Fondazione CRT(Cassa di Risparmio di Torino,RF=2022.0618)to LB。
Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall...
关键词：PLASTICITY al. ARREST 
Vascular smooth muscle cell plasticity in the tumor microenvironment
《Cancer Communications》2025年第2期167-171,共5页Caitlin F.Bell Richard A.Baylis Nicolas G.Lopez Wei Feng Ma Hua Gao Fudi Wang Sharika Bamezai Changhao Fu Yoko Kojima Shaunak S.Adkar Lingfeng Luo Clint L.Miller Nicholas J.Leeper 
supported by the Damon Runyon Cancer Research Foundation(PST 33-21 to CFB);the National Institutes of Health(R35 HL144475 to N.J.L.);the American Heart Association(EIA34770065 to N.J.L.);the Fondation Leducq(‘PlaqOmics’18CVD02 to N.J.L.and C.L.M.).
Smooth muscle cell(SMC)plasticity plays a prominent role in the pathogenesis of multiple diseases.This phenomenon is characterized by the loss of canonical SMC marker gene expression(such as Acta2 and Myh11),increased...
关键词：PLASTICITY typically TRANSLATIONAL 
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