Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms  

作　　者：Rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho 

机构地区：[1]iNOVA4Health,NOVA Medical School|Faculdade de Ciências Médicas,NMS|FCM,Universidade Nova de Lisboa,Lisboa,Portugal

出　　处：《Neural Regeneration Research》2025年第7期1995-1996,共2页中国神经再生研究（英文版）

基　　金：supported by PTDC-01778/2022-NeuroDev3D,iNOVA4Health(UIDB/04462/2020 and UIDP/04462/2020);LS4FUTURE(LA/P/0087/2020)。

摘　　要：Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关 键 词：PLASTICITY STRUCTURAL MECHANISMS 

分 类 号：Q42[生物学—神经生物学]