Dynamics of epithelial-mesenchymal plasticity driving cancer drug resistance  

作　　者：Rashmi Bangarh Reena V.Saini Adesh K.Saini Tejveer Singh Hemant Joshi Seema Ramniwas Moyad Shahwan Hardeep Singh Tuli 

机构地区：[1]Department of Bio-Sciences and Technology,Maharishi Markandeshwar Engineering College,Maharishi Markandeshwar(Deemed to Be University),Mullana,Ambala 133207,India [2]Translational Oncology Laboratory,Department of Zoology,Hansraj College,Delhi University,New Delhi 110007,India [3]School of Biotechnology,Jawaharlal Nehru University,New Delhi 110067,India [4]University Centre for Research and Development University Instute of Pharmaceutical Sciences,Chandigarh University,Mohali 140413,India [5]Department of Clinical Sciences,College of Pharmacy and Health Sciences,Ajman University,Ajman 346,United Arab Emirates [6]Centre of Medical and Bio-Allied Health Sciences Research,Ajman University,Ajman 346,United Arab Emirates

出　　处：《Cancer Pathogenesis and Therapy》2025年第2期120-128,共9页癌症发生与治疗(英文)

基　　金：supported by the DST-INSPIRE(Department of Science&Technology-Innovation in Science Pursuit for Inspired Research)Fellowship(No.IF210078);the Department of Science and Technology(Technology Development Program),Government of India(No.TDP/BDTD/54/2021/General);the Indian Council of Medical Research-Department of Health Research(ICMR-DHR)Young Scientist Fellowship(F.No:R.12014/29/2022/HR).

摘　　要：Epithelial-mesenchymal transition(EMT)promotes several cancers by increasing tumor cell motility,disrupting epithelial cell phenotypes,apical-basal polarity,and intracellular connections,and enhancing tumor resistance to immunotherapy and chemotherapy.Mesenchymal-epithelial transition(MET),the opposite of EMT,causes tumor metastasis.EMT drives primary tumor cells,whereas MET inhibits them.Importantly,the complex network of EMT includes cell-cell interactions in the tumor microenvironment.Transcription factors,post-translational regulation,cytokine-mediated signaling,and microRNAs control EMT.In this review,we discussed how molecular mechanisms,signaling networks,and epithelial/mesenchymal states affect cancer treatment resistance and the tumor microenvironment.Research on immunotherapy and chemotherapy problems associated with EMT suggests that targeting EMT might be a potential cancer treatment resistance strategy.

关 键 词：Epithelial-mesenchymal transition Tumor microenvironment METASTASIS Cancer drug resistance 

分 类 号：R730.5[医药卫生—肿瘤]