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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor
《Neural Regeneration Research》2025年第9期2583-2584,共2页Leenor Alfahel Aleksandar Rajkovic Adrian Israelson 
supported by grants from the Israel Science Foundation(ISF#284/19);German Israeli Foundation(GIF#I-116-415.6-2016)(to AI)。
Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system develo...
关键词：IMMUNITY SCLEROSIS 
Translational machinery and translation regulation in axon regeneration
《Neural Regeneration Research》2025年第5期1392-1394,共3页Homaira Nawabi Stephane Belin 
supported by ANR(ANR-21-CE16-0008-01);ANR(ANR-21-CE16-0008-02 and ANR-23-CE52-0007);UNADEV(A22018CS);UNADEV(A22020CS)(to SB);ERC(ERC-St17-759089)(to HN)。
Over the centuries,the regeneration field has been puzzled by the dual response of the central nervous system(CNS-brain,spinal cord,cranial nervesⅠandⅡ)and the peripheral nervous system(PNS that refers to all the ne...
关键词：NERVES ORGANS muscles 
Scientific psychiatry within technical reach
《World Journal of Psychiatry》2025年第3期337-340,共4页Diyana Najar Drozdstoy Stoyanov 
Supported by Innovation Program for the Development of MU-PLOVDIV(SRIPD-MUP),Creation of a Network of Research Higher Schools,National Plan for Recovery and Sustainability,European Union(NextGenerationEU),No.BG-RRP-2.004-0007-C01.
This is an invited commentary on the paper by Zou et al,accepted for publication in World Journal of Psychiatry.It reflects the findings of the authors in the broader context of the search for scientifically sound and...
关键词：DEPRESSION Prefrontal cortex NEUROIMAGING Nomothetic network psychiatry Translational neuroimaging 
Advances and applications of genome-edited animal models for severe combined immunodeficiency
《Zoological Research》2025年第1期249-260,共12页Xiao Zheng Chun-Hui Huang Sen Yan Ming-Deng Rong 
supported by the Postdoctoral Fellowship Program of CPSF (GZC20231064);China Postdoctoral Science Foundation (2024M761345);Guangzhou Basic and Applied Basic Research Foundation (2024A04J6615);Scientific Research Project of Southern Medical University Stomatological Hospital (PY2023004);National Key Research and Development Program of China (2021YFA0805300);National Natural Science Foundation of China (82171244,32470564)。
Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processe...
关键词：Gene-editing technology Animal model Translational biomedicine Severe combined immunodeficiency disease 
Vascular smooth muscle cell plasticity in the tumor microenvironment
《Cancer Communications》2025年第2期167-171,共5页Caitlin F.Bell Richard A.Baylis Nicolas G.Lopez Wei Feng Ma Hua Gao Fudi Wang Sharika Bamezai Changhao Fu Yoko Kojima Shaunak S.Adkar Lingfeng Luo Clint L.Miller Nicholas J.Leeper 
supported by the Damon Runyon Cancer Research Foundation(PST 33-21 to CFB);the National Institutes of Health(R35 HL144475 to N.J.L.);the American Heart Association(EIA34770065 to N.J.L.);the Fondation Leducq(‘PlaqOmics’18CVD02 to N.J.L.and C.L.M.).
Smooth muscle cell(SMC)plasticity plays a prominent role in the pathogenesis of multiple diseases.This phenomenon is characterized by the loss of canonical SMC marker gene expression(such as Acta2 and Myh11),increased...
关键词：PLASTICITY typically TRANSLATIONAL 
Intensity enhancement of Raman active and forbidden modes induced by naturally occurred hot spot at GaAs edge
《Chinese Physics B》2025年第1期180-187,共8页Tao Liu Miao-Ling Lin Da Meng Xin Cong Qiang Kan Jiang-Bin Wu Ping-Heng Tan 
Project supported by the National Key Research and Development Program of China(Grant No.2023YFA1407000);the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB0460000);the National Natural Science Foundation of China(Grant Nos.12322401,12127807,and 12393832);CAS Key Research Program of Frontier Sciences(Grant No.ZDBS-LY-SLH004);Beijing Nova Program(Grant No.20230484301);Youth Innovation Promotion Association,Chinese Academy of Sciences(Grant No.2023125);CAS Project for Young Scientists in Basic Research(Grant No.YSBR-026)。
Edge structures are ubiquitous in the processing and fabrication of various optoelectronic devices.Novel physical properties and enhanced light–matter interactions are anticipated to occur at crystal edges due to the...
关键词：polarized Raman spectroscopy EDGE enhanced Raman scattering spatial translational symmetry breaking electromagnetic field redistribution finite-difference time-domain simulation 
Correction to "Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint"
《Neuroprotection》2024年第4期329-329,共1页
Role of macrophages in aortic dissection pathogenesis:insights from preclinical studies to translational prospective
《Science China(Life Sciences)》2024年第11期2354-2367,共14页Shiyi Li Weiguo Fu Lixin Wang 
fundings from the National Natural Science Foundation of China(81970412);Shanghai Municipal Science and Technology Commission Innovation Fund(22S31904800);Fujian Province Health Science and Technology Fund(2021GGB030).
Aortic dissection is a critical vascular disease that is characterized by a high mortality rate and inflammation significantly influences its onset and progression.Recent studies highlight the integral role of macroph...
关键词：aortic dissection MACROPHAGES extracellular matrix CYTOKINES 
Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4314-4340,共27页Yunlong Shan Mengying Zhang Enxiang Tao Jing Wang Ning Wei Yi Lu Qing Liu Kun Hao Fang Zhou Guangji Wang 
National Natural Science Foundation of China(82104184,82073928,82373949);Leading Technology Foundation Research Project of Jiangsu Province(BK20192005);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00005);Nanjing Scientific and Technological Special Project for Life and Health(202110006);“Double First-Class”University Project(CPU2018GF01,China);Jiangsu Province“333”project,China;and the Fundamental Research Funds for the Central Universities(2632023TD03).
Over the past two decades,mesenchymal stem/stromal cell(MSC)therapy has made substantial strides,transitioning from experimental clinical applications to commercial products.MSC therapies hold considerable promise for...
关键词：CHARACTERISTICS TRANSLATIONAL PRECISE 
Exploring the groundwater response to rainfall in a translational landslide using the master recession curve method and cross-correlation function
《Journal of Groundwater Science and Engineering》2024年第3期237-252,共16页Cheng-peng Ling Qiang Zhang 
This research is part of the"Survey and warning zonation of huge geological hazards in Southwestern China"project(No.12120113010100);which is supported by the China Geological Survey,and the"Application of electrical resistivity tomography to evaluate the temporal and spatial variation in matric suction of landslide"project(No.41402268);which is supported by the National Natural Science Foundation of China;the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Chengdu University of Technology)(No.2007DA810083)。
Rainfall is a common trigger for landslide reactivation,as it raises groundwater levels and reduces bedrock or soil shear resistance.This study focuses on the Kualiangzi landslide in the southern region of Sichuan Pro...
关键词：Translational landslide RAINFALL GROUNDWATER Lag response Water table fluctuation Recharge pathway 
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