Vascular smooth muscle cell plasticity in the tumor microenvironment  

作　　者：Caitlin F.Bell Richard A.Baylis Nicolas G.Lopez Wei Feng Ma Hua Gao Fudi Wang Sharika Bamezai Changhao Fu Yoko Kojima Shaunak S.Adkar Lingfeng Luo Clint L.Miller Nicholas J.Leeper 

机构地区：[1]Department of Medicine,Division of Cardiovascular Medicine,Stanford University School of Medicine,Stanford,California,USA [2]Stanford Cardiovascular Institute,Stanford University,Stanford,California,USA [3]Department of Medicine,Division of Cardiology,University of Colorado Anschutz Medical Campus,Aurora,Colorado,USA [4]Department of Surgery,Division of Vascular Surgery,Stanford University School of Medicine,Stanford,California,USA [5]Department of Medicine,Division of Cardiology,University of California San Francisco,San Francisco,California,USA [6]Center for Public Health Genomics,University of Virginia,Charlottesville,Virginia,USA [7]Medical Scientist Training Program,University of Virginia School of Medicine,Charlottesville,Virginia,USA [8]Department of Biochemistry and Molecular Genetics,University of Virginia,Charlottesville,Virginia,USA

出　　处：《Cancer Communications》2025年第2期167-171,共5页癌症通讯(英文)

基　　金：supported by the Damon Runyon Cancer Research Foundation(PST 33-21 to CFB);the National Institutes of Health(R35 HL144475 to N.J.L.);the American Heart Association(EIA34770065 to N.J.L.);the Fondation Leducq(‘PlaqOmics’18CVD02 to N.J.L.and C.L.M.).

摘　　要：Smooth muscle cell(SMC)plasticity plays a prominent role in the pathogenesis of multiple diseases.This phenomenon is characterized by the loss of canonical SMC marker gene expression(such as Acta2 and Myh11),increased proliferation and migration,and the upregulation of genes typically associated with other cell types,such as macrophages[1–3].This process is best described in atherosclerosis,where phenotype switching,clonal expansion,and the aberrant expression of inflammatory and matrix proteins contribute to lesion progression and plaque instability[1–4].However,this phenomenon has not been studied in the context of tumorigenesis.Here,we investigated whether SMC diversity and plasticity play a role in the tumor microenvironment(TME)using wellestablished SMC-lineage tracing mouse models,single cell RNA sequencing(scRNA-seq),and in silico ligandreceptor predictions.Detailed study methods are described in the supplementary materials and methods section.The goal of this work was to determine if vascular SMC plasticity should be prioritized as a translational target in oncology.

关 键 词：PLASTICITY typically TRANSLATIONAL 

分 类 号：R73[医药卫生—肿瘤]