METABOLIC

作品数：1270被引量：3353H指数：24
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Metabolic reprogramming of astrocytes:Emerging roles of lactate
《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning 
supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...
关键词：ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment 
Rapamycin as a preventive intervention for Alzheimer’s disease in APOE4 carriers:Targeting brain metabolic and vascular restoration
《Neural Regeneration Research》2026年第2期685-686,共2页Ai-Ling Lin Chetan Aware 
supported by National Institute on Aging(NIH-NIA)R01AG054459(to ALL).
Alzheimer’s disease(AD)is the most common form of dementia,affecting over 50 million people worldwide.This figure is projected to nearly double every 20 years,reaching 82 million by 2030 and 152 million by 2050(Alzhe...
关键词：lipid transporterexists Dementia alzheimer s disease ad RAPAMYCIN Brain metabolic Vascular restoration Amyloid beta plaques APOE 
Exploring the impact of mobile device use on mealtime distractions and its consequences for metabolic health:A narrative minireview
《World Journal of Clinical Cases》2025年第17期7-15,共9页Muhammad Shahzad Aslam 
The habitual use of smartphones during meals has become a common behavior,raising concerns about its potential impact on eating habits and metabolic health.The present narrative review investigates how using a smartph...
关键词：Digital devices Smartphone usage Mealtime behavior Eating habits Postprandial glucose Screen time Dietary patterns Metabolic responses Technological distractions Mobile health 
Immunomodulatory behavior of CircRNAs in tumor microenvironment
《Oncology Research》2025年第5期1105-1119,共15页HAISU LIANG WEI YAN ZHI LIU YUNBO HE JIAO HU ZHIWEI SHU HUIHUANG LI BELAYDI OTHMANE WENBIAO REN CHAO QUAN DONGXU QIU MINFENG CHEN WEI XIONG BINGNAN ZHANG PEIHUA LIU 
supported by the National Natural Science Foundation of China(82103298);Basic Research Project of Science and Technology Cooperation in Qiandongnan Prefecture(No.2023-16).
Circular RNAs(circRNAs)are a type of non coding RNA that possess unique single stranded circular structures formed through reverse splicing mechanisms.Due to the lack of a free end that is typically susceptible to deg...
关键词：Circular RNA(circRNA) Immune response Metabolic reprogramming TUMOR Tumor microenvironment(TME) 
Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission
《Neural Regeneration Research》2025年第5期1403-1404,共2页Oliver Kann Lennart Soder Babak Khodaie 
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...
关键词：consequences FIGURE RESTORATION 
Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
《World Journal of Diabetes》2025年第5期331-345,共15页Zhong-Yong Zhang Yu-Ming Wang Ning Wang Yuan-Song Wang Hui Zhang Duo Wang Li-Xin Wang Huan-Tian Cui Wei-Bo Wen Shu-Quan Lv Yong-Jun Cao 
Supported by the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program,No.H2020110287;Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province,No.7[2024];Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.3[2024];Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,No.SZX2020015;Jiangsu Province Chinese Medicine Science and Technology Development Program Project,No.YB2020065.
BACKGROUND Diabetic nephropathy(DN)is a major complication of diabetes,marked by progressive renal damage and an inflammatory response.Although research has investigated the pathological mechanisms underlying DN,effec...
关键词：Diabetic nephropathy Shenzhuo formulation TRANSCRIPTOMIC METABOLOMIC Cytochrome P450 Arachidonic acid metabolic INFLAMMATORY Oxidative stress 
Risks of liver cirrhosis,hepatocellular carcinoma,hepatic-related complications,and mortality in patients with type 2 diabetes in Taiwan
《World Journal of Diabetes》2025年第5期202-215,共14页Hua-Fen Chen Yung-Yueh Chang Peter Chen Xiao-Han Shen Chin-Huan Chang Wan-Lun Hsu 
Supported by The Far Eastern Memorial Hospital,No.FEMH-2022-C-015,No.FEMH-2022-C-017 and No.FEMH-2023-C-082.
BACKGROUND Hepatitis B and C and alcoholic liver disease are the principal causes of hepaticrelated morbidity and mortality.However,evidence of the associations between diabetes without the above risk factors and hepa...
关键词：Type 2 diabetes mellitus Liver cirrhosis Hepatocellular carcinoma Hepatic-related complications MORTALITY Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 
Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes
《World Journal of Diabetes》2025年第5期458-463,共6页Eguono Deborah Akpoveta Uchenna E Okpete Haewon Byeon 
Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287。
Managing type 2 diabetes mellitus remains a significant challenge,particularly for individuals with persistently poor glycemic control.Although inadequate glycemic regulation is a well-established public health concer...
关键词：Glycemic trajectories Personalized treatment Diabetes control Therapeutic inertia Glycated hemoglobin improvement Metabolic challenges 
Unlocking the secrets of exercise:A pathway to enhanced insulin sensitivity and skeletal muscle health in type 2 diabetes
《Journal of Sport and Health Science》2025年第2期71-74,共4页Juleen R.Zierath Aidan J.Brady Kirstin A.Macgregor Joaquin Ortiz de Zevallos Ben Stocks 
supported by the Swedish Research Council(201500165);a Wallenberg Scholars Award from the Knut and Alice Wallenberg Foundation(KAW 2023.0312);The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen,partially funded by an unrestricted donation from the Novo Nordisk Foundation(NNF23SA0084103).
1.Exercise enhances muscle function and insulin sensitivity Skeletal muscle plays a fundamental role in not only locomotion,but also systemic metabolism.In people with type 2 diabetes,skeletal muscle is a major site o...
关键词：impaired insulin signaling metabolic dysfunction muscle function type diabetes insulin sensitivity reduced glucose transport activity skeletal muscle 
Metabolic reprogramming: a new option for the treatment of spinal cord injury
《Neural Regeneration Research》2025年第4期1042-1057,共16页Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang 
supported by the National Natural Science Foundation of China,No.82202681(to JW);the Natural Science Foundation of Zhejiang Province,Nos.LZ22H090003(to QC),LR23H060001(to CL).
Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they cause.Despite the ongoing development of various therapies for spinal cord injuries,their effectiveness ...
关键词：AXONS GLYCOLYSIS metabolic reprogramming metabolism mitochondria neural regeneration NEUROPROTECTION oxidative phosphorylation spinal cord injury therapy 
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