METABOLOMIC

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Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
《World Journal of Diabetes》2025年第5期331-345,共15页Zhong-Yong Zhang Yu-Ming Wang Ning Wang Yuan-Song Wang Hui Zhang Duo Wang Li-Xin Wang Huan-Tian Cui Wei-Bo Wen Shu-Quan Lv Yong-Jun Cao 
Supported by the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program,No.H2020110287;Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province,No.7[2024];Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.3[2024];Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,No.SZX2020015;Jiangsu Province Chinese Medicine Science and Technology Development Program Project,No.YB2020065.
BACKGROUND Diabetic nephropathy(DN)is a major complication of diabetes,marked by progressive renal damage and an inflammatory response.Although research has investigated the pathological mechanisms underlying DN,effec...
关键词：Diabetic nephropathy Shenzhuo formulation TRANSCRIPTOMIC METABOLOMIC Cytochrome P450 Arachidonic acid metabolic INFLAMMATORY Oxidative stress 
Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis
《Science China(Life Sciences)》2025年第4期1042-1056,共15页Jinzhou Feng Shi Tang Xiaolin Yang Mengjie Zhang Zhizhong Li Shaoru Zhang Yongliang Han Yongmei Li Philippe P.Monnier Gang Yu Peng Zheng Cunjin Zhang Ke Xu Xinyue Qin 
supported by the National Science Foundation of China (81701191, 82301720);Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0973, CSTB2023NSCQMSX0183, CSTB2023NSCQ-BHX0214);China Postdoctoral Science Foundation (2022M722384, 2023MD734128);the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2020FYYX104);Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010);Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214);the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310);CQMU Program for Youth Innovation in Future Medicine (W0168)。
Although disturbances in the gut microbiome have been implicated in multiple sclerosis(MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes aff...
关键词：relapsing remitting multiple sclerosis gut microbiota 16S rRNA gene sequence untargeted metabolomics lipid metabolism biomarker 
Metabolomic reveals the inhibition mechanism of proline on hexanal production in chicken meat
《Food Science and Human Wellness》2025年第2期662-670,共9页Huanxian Cui Yuxi Jin Yanke Wang Xiaoya Yuan Li Liu Jie Wen Guiping Zhao 
funded by grants from the State Key Laboratory of Animal Nutrition(2004DA125184G2109);Basic Research from Chinese Academy of Agricultural Sciences(Y2019XK06);the Agricultural Science and Technology Innovation Program(ASTIP-IAS04);the Earmarked Fund for Modern Agro-Industry Technology Research System(CARS-41)。
Hexanal contributes significantly to meat flavor.The aim of this study was to identify the metabolic pathways of hexanal formation in chicken meat.We found 32 metabolites associated with hexanal content in chicken mea...
关键词：FLAVOR Amino acids Fatty acids Negative regulation Pyrimidine metabolism pathway 
Polystyrene microplastics affect the early life stages of large yellow croaker Pseudosciaena crocea
《Journal of Oceanology and Limnology》2025年第2期644-655,共12页Hailing YANG Fangzhu WU Fangping CHEN Jiangning ZENG Qikun YANG Lukuo MA Tianqi ZHAI Yu ZHOU Wei HUANG 
Supported by the Pioneer and Leading Goose R&D Program of Zhejiang(No.2023C03130);the National Key R&D Program of China(No.2019YFD0901101);the National Natural Science Foundation of China(No.42076169);the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(Nos.SL2022ZD203,SL2022MS012);the Zhejiang Provincial Natural Science Founds for Distinguished Young Scientists(No.LR21D060001);the State Key Laboratory of Satellite Ocean Environment Dynamics(No.SOEDZZ1902);the ChinaAPEC Cooperation Fund(No.2029901)。
Microplastics(MPs)have garnered significant international scrutiny as an emerging environmental pollutant,constituting one of the four principal global environmental threats and posing potential health hazards to huma...
关键词：polystyrene microplastic(PS-MP) early life stage Pseudosciaena crocea large yellow croaker DEVELOPMENT METABOLOMIC 
Metabolomic and gut-microbial responses of earthworms exposed to microcystins and nano zero-valent iron in soil
《Journal of Environmental Sciences》2025年第4期340-348,共9页Yifan Wang Chunlong Zhang Daohui Lin Jianying Zhang 
supported by the National Natural Science Foundation of China(No.21777139);the National Key Research and Development Program of China(No.2017YFA0207003).
The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost ...
关键词：Nano zero-valent iron MICROCYSTIN-LR Mixed exposure Vermiremediation Metabolic pathways Gut microbiota 
Metabolomic and Transcriptomic Insights into Enhanced Paclitaxel Biosynthesis in Cultivated Taxus cuspidata
《Phyton-International Journal of Experimental Botany》2025年第4期1137-1158,共22页Dandan Wang Jiaxin Chen Yanwen Zhang 
supported by grants from the National Science Foundation of China to Yanwen Zhang(32272757,31972363);grants from Liaoning Provincial Department of Education Project to Dandan Wang(JYTMS20230698);grants from the Liaoning Provincial Science and Technology.Fund Project to Dandan Wang(2023JH2/101700200).
Taxus cuspidata,a rare species of the Taxus genus,and its wild resources are under severe threat.The development of cultivated species has become an important strategy to replace wild species.The objective of this wor...
关键词：T.cuspidata wild species cultivated species metabolomics TRANSCRIPTOMICS PACLITAXEL 
Reevaluating statistical methods in metabolomic studies:A case for Spearman’s correlation
《Molecular Plant》2025年第3期383-383,共1页Yoshiyasu Takefuji 
Dear Editor,Recently,Liang et al.(2024)conducted comprehensive genome resequencing and metabolomic analyses of 299 representative accessions from extant citrus species,offering an extensive overview of genetic diversi...
关键词：correlation analysis Spearman s correlation metabolomic studies genetic diversity metabolic profiles metabolomic analyses genome resequencing annotated metabolites metabolite content 
Genomic,transcriptomic,and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin’s orchid
《Molecular Plant》2025年第3期392-415,共24页Kai Jiang Birger Lindberg Møller Shaofan Luo Yu Yang David R.Nelson Elizabeth Heather Jakobsen Neilson Joachim Møller Christensen Kai Hua Chao Hu Xinhua Zeng Mohammed Saddik Motawie Tao Wan Guang-Wan Hu Guy Eric Onjalalaina Yijiao Wang Juan Diego Gaitán-Espitia Zhiwen Wang Xiao-Yan Xu Jiamin He Linying Wang Yuanyuan Li Dong-Hui Peng Siren Lan Huiming Zhang Qing-Feng Wang Zhong-Jian Liu Wei-Chang Huang 
supported by grants from the Shanghai Landscaping and City Appearance Administrative Bureau(G222406,G232408);Sino-Africa Joint Research Center,CAS(SAJC201607);the Science and Technology Commission of Shanghai Municipality(19390743600);the National Wild Plant Germplasm Resource Centre for Shanghai Chenshan Botanical Garden(ZWGX2102);to W.C.H.and K.J.,and by a Distinguished Investigator grant(NNF190CO05456);from the Novo Nordisk Foundation to B.L.M.E.H.J.N.acknowledges funding from the Novo Nordisk Foundation(0054890);the Independent Research Fund Denmark(1131-00002B and 1051-00083 B).
Angraecum sesquipedale,also known as Darwin’s orchid,possesses an exceptionally long nectar spur.Charles Darwin predicted the orchid to be pollinated by a hawkmoth with a correspondingly long proboscis,later identifi...
关键词：Angraecum sesquipedale whole genome sequence white floral scent convergent evolution flavin monooxygenase CYP79 absence 
Metabolomic profiling and prognostication in CoVID-19 acute respiratory distress syndrome
《Journal of Intensive Medicine》2025年第1期108-110,共3页David Furfaro Xiaoyu Che Wenhao Gou Matthew J.Cummings Nischay Mishra Daniel Brodie Thomas Briese Oliver Fiehn W.Ian Lipkin Max R.O'Donnell 
CHEST Foundation Grant in COVID-192020(DMF).
To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COV...
关键词：DISTRESS ACUTE Metab 
Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma
《Asian Journal of Andrology》2025年第1期101-112,共12页Fang-Xing Zhang Xi Chen De-Cao Niu Lang Cheng Cai-Sheng Huang Ming Liao Yu Xue Xiao-Lei Shi Zeng-Nan Mo 
supported by the National Natural Science Foundation of China(No.81770759 and No.82270806);Innovation Project of Guangxi Graduate Education(No.YCBZ2022094).
Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is a complex disease that is often accompanied by mental health disorders.However,the potential mechanisms underlying the heterogeneous clinical presentation of...
关键词：BIOMARKER chronic prostatitis/chronic pelvic pain syndrome DEPRESSION INFLAMMATION metabolomics 
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